Demonstrations of Lactotrophic Activity of Human Urinary Extracts in Rabbits, Rats and Pigeons

Berswordt-Wallrabe, Ilse v.; Flaskamp, D.; Jantzen, Kim

doi:10.1530/acta.0.056s126

Cited by 3 publications

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“…A more precise evaluation of prolactin secretion should be based on frequent blood sampling during the day and night or possibly on evaluation of the total output in 24-hour urine collections. The fact that lactotrophic activity has been found by biological methods in urinary extracts (von Berswordt et al, 1967) favours this last solution.…”

Section: Discussionmentioning

confidence: 99%

Circadian Periodicity of Serum Prolactin Concentration in Man

Nokin¹,

Vekemans²,

L’Hermite³

et al. 1972

BMJ

146

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SummaryImmunoreactive human serum prolactin of pituitary origin has been measured by a radioimmunoassay developed for ovine prolactin. Blood samples were coilected at four-hour intervals during a 24-hour period from 12 non-pregnant women, three pregnant women, and seven adult men. A circadian periodicity was found in serum prolactin concentration, with peak values during the night, between 1 a.m. and 5 a.m. for the nonpregnant women, and at 5 a.m. for the adult men. Mean serum levels of prolactin were 1'5 times higher in nonpregnant women than in men. In women investigated during the last month of their pregnancy the mean serum prolactin levels were 2'3 times higher than in the non-pregnant women, but there was no circadian periodicity. Introduction A circadian periodicity in serum prolactin concentration has been found in rats (Clark and Baker, 1964;Dunn et al., 1972). The purpose of the present study was to investigate whether a similar rhythm exists in man.

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Section: Discussionmentioning

confidence: 99%