Demonstration of θ-AKR Differentiation Antigen in Rat Tissue by Mouse Alloantiserum

Micheel, B; Pasternak, G; Steuden, J

doi:10.1038/newbio241221a0

Cited by 20 publications

(9 citation statements)

References 6 publications

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“…W3/13 binds to both thymocytes and peripheral T cells in the rat, (b) a rabbit anti-Thy-1.1 antiserum, which had been extensively absorbed to render it specific for Thy-l.1. This reagent binds strongly to rat thymocytes (19) and binding to TDL can be detected using a polyvalent anti-Ig second stage reagent (20). The second stage reagent for anti-Pta antibody and specificity W3/13 was fluorescent rabbit anti-rat Ig and for Thy-1.1 antibody was sheep-anti-rabbit Ig.…”

Section: Methodsmentioning

confidence: 99%

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

Hall¹,

Dorsch²,

Roser³

1978

The Journal of Experimental Medicine

113

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The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.

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Section: Methodsmentioning

confidence: 99%

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

Hall¹,

Dorsch²,

Roser³

1978

The Journal of Experimental Medicine

113

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“…Since the rat has only the Thy-1.1 specificity [2,13,14,25], specific adsorption should lead to the depiction of anti-Thy-1.1, but not anti-Thy-1.2 activity.…”

Section: Quantitative Absorptionsmentioning

confidence: 99%

Distribution of Thy-1 Differentiation Alloantigen in the Rat Nervous System and in a Cell Line Derived from a Rat Peripheral Neurinoma

Acton¹,

Pfeiffer²

1978

Dev Neurosci

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The expression of the Thy-1 ''differentiation alloantigen'' was analyzed in rat tissues of two strains. Cerebrum was shown to express an amount of Thy-1 equivalent to the thymus. The cerebellum, brain stem and spinal cord expressed approximately one-half this amount, and the olfactory bulb expressed 10- to 15-fold less. Of the peripheral nervous system tissues examined, only cauda equina expressed substantial amounts of Thy-1, although minor amounts were found on the lumbar roots and trigeminal nerve. Kidney, spleen, liver, salivary gland and testes expressed little or no Thy-1. Several cell lines derived from nervous system tumors were also examined. RN-1, a line established from a rat peripheral neurinoma, expressed Thy-1 at levels comparable to thymus.

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“…In summary, the generation of a non-competively binding anti-canine-Thy-1 mAb pair came as a surprise because, although it was known that antibodies against monomorphic and allotypic determinants bind to different sites on the rodent Thy-1 molecules, these always cross-inhibit each other (1 5,22,23 and Thierfelder unpublished).…”

Section: Dog14-fitcmentioning

confidence: 99%

Rat monoclonal antibodies against three different epitopes of the canine Thy‐1 and their depletion capacity in vivo

Voss¹,

Kremmer²,

Schumm³

et al. 1994

Tissue Antigens

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Demonstration of θ-AKR Differentiation Antigen in Rat Tissue by Mouse Alloantiserum

Cited by 20 publications

References 6 publications

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

Distribution of Thy-1 Differentiation Alloantigen in the Rat Nervous System and in a Cell Line Derived from a Rat Peripheral Neurinoma

Rat monoclonal antibodies against three different epitopes of the canine Thy‐1 and their depletion capacity in vivo

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