Demonstration of sweat allergy in cholinergic urticaria

Adachi, Jun; Aoki, Toshiyuki; Yamatodani, Atsushi

doi:10.1016/0923-1811(94)90088-4

Cited by 59 publications

(43 citation statements)

References 12 publications

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“…Herxheimer [8]clearly demonstrated the importance of an intact sympathetic cholinergic pathway in development of whealing, the rash being easily blocked by prior atropinisation of the skin. A recent suggestion that allergy to sweat could be causative [9]has yet to be confirmed, and could not be supported by the author’s own (unpublished) observations. Passive transfer experiments suggest that a circulating serum factor may be involved [10].…”

Section: Physical Urticariasmentioning

confidence: 41%

Pathophysiology of Chronic Urticaria

Greaves¹

2002

Int Arch Allergy Immunol

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Chronic urticaria includes several different subsets with distinct pathophysiologies, and with important implications for investigation and treatment. Chronic ‘idiopathic’ urticaria represents a special challenge, which, until recently, was not taken up by dermatological or immunological investigators. However, it has now emerged that at least 30% of patients possess histamine-releasing autoantibodies against FcΕR1, or less commonly IgE itself. These autoantibodies are causative. Recent work implicates complement activation in most cases. Functional (i.e. histamine releasing) autoantibodies are specific to chronic urticaria. However, immunoreactive (non-histamine-releasing) anti-FcΕR1 autoantibodies can be found in sera of patients with physical urticarias and with autoimmune connective tissue and bullous diseases. The reason for the occurrence of this disease type in some individuals but not others is unclear. One possibility is the development, in genetically predisposed persons, of autoantibodies by molecular mimicry – perhaps against lipopolysaccharide of Helicobacter pylori, an organism frequently infecting the upper gastrointestinal tract of chronic urticaria patients.

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Section: Physical Urticariasmentioning

confidence: 41%

Pathophysiology of Chronic Urticaria

Greaves¹

2002

Int Arch Allergy Immunol

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“…Those with the atopic diathesis tended to show responsiveness to more diluted sweat than did normal persons. In 1994, Adachi et al [5] reported that patients with CU have hypersensitivity to autologous sweat. All 20 patients with CU showed positive immediate-type skin reactions for autologous sweat at 2 0 -2 9 dilutions, whereas none of the normal controls responded to their own sweat.…”

Section: Sweat Hypersensitivity In Cholinergic Urticaria and Atopic Dmentioning

confidence: 98%

“…However, the precise underlying mechanisms of the whealing response in CU are yet to be clarifi ed. In 1994, Adachi et al [5] reported that hypersensitivity to autologous sweat could be involved in the pathogenesis of CU. This interesting report led us to examine whether patients with CU respond to autologous sweat and/or to autologous serum.…”

Section: Introductionmentioning

confidence: 99%

New concepts of hive formation in cholinergic urticaria

Horikawa

Fukunaga²,

Nishigori³

2009

Curr Allergy Asthma Rep

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Patients with cholinergic urticaria (CU) show a number of small, short-lasting hives when their body core temperature increases, usually during sweating following exercise or bathing. The precise mechanism(s) of hive formation in CU has been unclear except for the involvement of acetylcholine. We recently reported that most CU patients show immediate-type skin responses to their own sweat, whereas the rest of CU patients have positive autologous serum skin tests (ASSTs). The former group produced satellite wheals following acetylcholine injection, whereas the latter group produced hives in conjunction with hair follicles. We propose two subtypes of CU: 1) a sweat-hypersensitivity type with strong hypersensitivity to autologous sweat, nonfollicular hives, development of satellite wheals, and lack of positive ASST; and 2) a follicular type with follicular hives and positive ASST, but no hypersensitivity to autologous sweat or satellite wheals. We discuss the mechanisms of hive formation in these subtypes.

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“…Adachi et al proposed that CU occurs after a type 1 allergic reaction to the patient's own sweat. They reported that the patients underwent autologous sweat testing and demonstrated an immediate skin reaction [8].…”

Section: Cholinergic Urticaria (Cu)mentioning

confidence: 99%

“…Because of the fact that the symptoms are not triggered by exogenous physical exposure, cholinergic urticaria is not considered as PU. Rather, it is induced by an increase in the body core temperature [8].…”

Section: Introductionmentioning

confidence: 99%

Chronic Inducible Urticaria Part I

Borlu¹,

Çınar²,

Kartal³

2017

A Comprehensive Review of Urticaria and Angioedema

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Urticaria is a common mast cell-driven disease which is characterized by red, itchy swellings. Urticaria, that persists more than 6 weeks in a repetitive manner (each lesion disappearing in <24 h), is called chronic urticaria. Chronic urticaria can be either spontaneous without the need of a trigger, or inducible in which with a known trigger the lesions can be provoked. Chronic inducible urticarias include the physical urticarias and some other forms such as cholinergic urticaria.

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Demonstration of sweat allergy in cholinergic urticaria

Cited by 59 publications

References 12 publications

Pathophysiology of Chronic Urticaria

Pathophysiology of Chronic Urticaria

New concepts of hive formation in cholinergic urticaria

Chronic Inducible Urticaria Part I

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