Demonstration of Separate Adrenergic and Cholinergic Fibres to the Vessels of the Rear Quarters of the Rat by Hemicholinium and a Proposed Role in Peripheral Vascular Regulation*

Species Distribution of Sympathetic Cholinergic Vasodilator Nerves in Skeletal Muscle

“…This finding is in agreement vith our results. O n the other hand, Fray and Leaders (1967) obtained vasodilataion in the hind quarters of the rat upon lumbar sympathetic chain stimulation after docking the adrenergic vasoconstrictor nervous response. Those authors interpreted heir results as indicating that sympathetic cholinergic vasodilator fibres exist in the ,at.…”

“…However, the vasodilatation observed was small (10 per cent decrease in perfuion pressure) and the response after atropine was not tested. It cannot be ruled out hat in the experiments of Fray and Leaders (1967) the vasodilatation obtained was :aused in other ways than by activating cholinergic vasodilators nerves e.g. by timulating adrenergic &receptors (cf.…”

“…The existence of sympathetic cholinergic vasodilator fibres have been reported by Fray and Leaders (1967) in the rat and by Feigl and Folkow (1963) The arterial pressure was recorded in the carotid artery and usually measured by a Statham pressure transducer ( P 23 AC). I n some experiments a mercury manometer was used instead.…”

An Examination of Adrenergic Axons Around Pancreatic Arterioles of the Cat for the Presence of Acetylcholinesterase by High Resolution Autoradiographic and Histochemical Methods

“…Evidence exists, however, which is incompatible with the hypothesis (Iversen, 1967;Fray & Leaders, 1967;Esterhuizen, Graham, Lever & Spriggs, 1967. Histochemical studies have revealed some situations in which acetylcholinesterase (ACHE) may be demonstrated in association with adrenergic nerves and others in which it may not (Jacobowitz & Koelle, 1965).…”

“…The hypothesis that a cholinergic mechanism mediates the release of noradrenaline from postganglionic sympathetic adrenergic nerve terminals was proposed by Burn & Rand in 1959 and the evidence in favour of this hypothesis was reviewed recently (Burn & Rand, 1965;Burn, 1967). Evidence exists, however, which is incompatible with the hypothesis (Iversen, 1967;Fray & Leaders, 1967;Esterhuizen, Graham, Lever & Spriggs, 1967. Histochemical studies have revealed some situations in which acetylcholinesterase (ACHE) may be demonstrated in association with adrenergic nerves and others in which it may not (Jacobowitz & Koelle, 1965).…”