Demonstration of parasites in toxoplasma lymphadenitis by fine‐needle aspiration cytology: Report of two cases

Zaharopoulos, Paul

doi:10.1002/(sici)1097-0339(200001)22:1<11::aid-dc4>3.3.co;2-s

Cited by 5 publications

(13 citation statements)

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“…For this purpose, enzyme-linked immunosorbent assay and indirect immunofluorescence methods are available for titration of the parasite-specific IgM antibody. [4][5][6] There are few reports of cervical toxoplasma lymphadenitis cases being diagnosed exclusively by fine-needle aspiration cytology (with serology). 5,6 Fine-needle aspiration cytology typically shows microgranulomas, consisting of small clusters of characteristic epithelioid histiocytes with only a few mature lymphocytes, and no evidence of necrosis, suppuration or giant cells, on a background of reactive lymphoid hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…7 Very few reports have defined the cytological criteria for a diagnosis of toxoplasma lymphadenitis. [6][7][8] There is a similar lack of reports on histopathological analysis. The histological criteria for a diagnosis of toxoplasma lymphadenitis include follicular hyperplasia with preservation of lymph node architecture, focal proliferation of transformed monocytoid B lymphocytes and small, scattered clusters of large, epithelioid-like histiocytes (with larger aggregates of these cells defined as granulomas).…”

Section: Discussionmentioning

confidence: 99%

“…The histological criteria for a diagnosis of toxoplasma lymphadenitis include follicular hyperplasia with preservation of lymph node architecture, focal proliferation of transformed monocytoid B lymphocytes and small, scattered clusters of large, epithelioid-like histiocytes (with larger aggregates of these cells defined as granulomas). 5,6 • Toxoplasma lymphadenitis was successfully diagnosed by fine-needle aspiration cytology • This method is useful for differentiating toxoplasma lymphadenitis from more serious causes of lymphadenopathy • Toxoplasma lymphadenitis can be diagnosed by haematoxylin and eosin staining of tissue sections or immunohistochemical analysis of fine-needle aspirates…”

Section: Discussionmentioning

confidence: 99%

“…6-8 Zaharopoulos reported pseudocysts (tachyzoites in histiocytes), with free tachyzoites observed in the background. 6 According to this author, Wright-Giemsa staining is useful for identifying tachyzoites in cytological preparations of toxoplasma lymphadenitis because detection with the Papanicolaou stain can be challenging.…”

Section: Discussionmentioning

confidence: 99%

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Toxoplasma lymphadenitis diagnosed by fine-needle aspiration cytology: a rare finding

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Toxoplasma lymphadenitis diagnosed by fine-needle aspiration cytology: a rare finding

et al. 2014

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“…3A-D). [43][44][45][46][47][48][49] The background is composed of a mixed lymphoid population, sometimes intact reactive follicular center cell fragments, and tingible body macrophages. This smear pattern reflects the histologic findings of small epithelioid clusters opposed to germinal centers.…”

Section: Volmar Et Almentioning

confidence: 99%

Fine-Needle Aspiration Biopsy of Lymph Nodes in the Modern Era

Volmar¹,

Singh²,

Gong³

2007

Pathology Case Reviews

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Fine-needle aspiration (FNA) biopsy has proven to be a rapid, cost-effective, and accurate means for evaluating a wide variety of conditions in almost any organ system. In some situations, conditions resulting in reactive lymphadenopathies can be discerned on clinical grounds, and many require no specific therapy. However, cases in which an atypical presentation or a prolonged clinical course occurs warrant further investigation of the enlarged lymph nodes, often with the aim of ruling out a malignancy. In such cases, FNA biopsy can provide a rapid and accurate means of ruling out lymphoma and metastatic disease. With the aid of flow cytometry, reactive lymphoid hyperplasia can be readily assessed. Discerning the exact cause of a reactive lymphadenopathy by FNA biopsy can be problematic but can be aided with an appropriate serologic workup (ie, toxoplasma titers, Epstein-Barr virus titers). Granulomatous lymphadenitis may be caused by mycobacterial or fungal organisms, which can be grown in culture or detected by modern molecular studies performed on the aspirated material (ie, PCR). Rapid and accurate assessment of metastatic disease, particularly carcinomas and melanomas, is readily accomplished by FNA biopsy, with an overall sensitivity, specificity, and accuracy of over 90%. In these cases, cell block material can be obtained for additional useful prognostic information. CASE REPORTT he patient was a 65-year-old man with a month-long history of enlarged lymph nodes in the left anterior cervical region. He had no prior malignancy and had had no recent dental work. Palpable lymph nodes were noted in the left anterior cervical chain. The lymph nodes were from 0.3 to 0.5 cm in diameter, firm, mobile, and slightly tender. The overlying skin appeared normal. Oral examination revealed no lesions. A fine-needle aspiration (FNA) biopsy was performed. Immediate evaluation revealed a mixed population of small and large lymphocytes and tingible body macrophages, suggesting a reactive process (Fig. 1A-D). Given the patient's age, additional passes were obtained for flow cytometry studies. Flow cytometry revealed CD19-positive B-cells that were polyclonal by and light chain expression (Fig. 1E, F). The findings were consistent with a reactive process. The patient was observed, and the lymphadenopathy resolved over the next several weeks. DISCUSSIONFNA biopsy is a rapid, cost-effective, and accurate means for the workup of lymphadenopathy. Often, an aspirated specimen provides sufficient information for appropriate patient triage, ie, to decide if a patient requires simple observation, antimicrobial therapy for an infection, or additional tissue for workup in the form of a core or excisional lymph node biopsy. FNA biopsy evaluation of lymphadenopathies requires strict adherence to the cytopathologic principal of the "triple test," ie, correlation of the cytologic findings with the clinical and radiographic findings. The etiology of lymphadenopathy is extensive and runs the gamut from innocuous/self-limited processes, to in...

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Disseminated nocardiosis diagnosed by fine needle aspiration biopsy: Quick and accurate diagnostic approach

et al. 2006

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Nocardia is an uncommon pathogen in immunocompetent patients; however, it has been increasingly recognized as a significant opportunistic pathogen in organ transplant patients. Diagnosis of Nocardiosis is usually made by microbiologic culture or cytologic examination of pulmonary specimens including, sputum, and brushing/washings or by histologic evaluation of tissue biopsy material. We report a case of subcutaneous Nocardiosis diagnosed by Fine-needle aspiration biopsy (FNA). The patient is a 66-year-old man with a history of lung transplantation and posttransplant lymphoproliferative disorder who presented with subcutaneous masses in the right upper arm and the left shoulder. FNA was performed in an outpatient clinic setting, with immediate morphologic assessment revealing filamentous branching organisms suspicious for Nocardiosis. Subsequent examination with special stains and microbiologic culture confirmed the diagnosis. The quick and accurate diagnosis by FNA led to emergent and appropriate treatment.

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Demonstration of parasites in toxoplasma lymphadenitis by fine‐needle aspiration cytology: Report of two cases

Cited by 5 publications

References 15 publications

Toxoplasma lymphadenitis diagnosed by fine-needle aspiration cytology: a rare finding

Toxoplasma lymphadenitis diagnosed by fine-needle aspiration cytology: a rare finding

Fine-Needle Aspiration Biopsy of Lymph Nodes in the Modern Era

Disseminated nocardiosis diagnosed by fine needle aspiration biopsy: Quick and accurate diagnostic approach

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