“…While sharing the indications for systemic use with other nonsteroidal anti-inflammatory drugs - including the symptomatic treatment of rheumatoid arthritis or osteoarthritis as well as the management of acute gouty arthritis, ankylosing spondylitis and other related pathologies [1] - flurbiprofen is preferentially used for the topical management of painful and/or inflammatory conditions of the oropharynx such as gingivitis, stomatitis, periodontitis, pharyngitis and laryngitis [2,3,4,5,6,7,8]. In these conditions, flurbiprofen formulations for the oromucosal route of administration (including lozenges, mouthwashes and oral sprays) have the advantage to enhance the local oromucosal concentration, allowing a local anti-inflammatory effect at lower dosages and a concomitantly reduced amount of absorbed drug, thus limiting the side effects related to systemic exposure [9,10].…”