The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment

Lima-Rodrigues, Manuel; Lamas, Nuno Jorge; Valle-Fernandes, Ana; Cruz, Andrea; Vieira, Artur; Oliveira, Pedro; Pedrosa, Jorge; Reis, Rui Manuel; Baltazar, Fátima; Almeida, Armando

doi:10.1007/s00011-010-0185-5

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…The better protective effect of etoricoxib on anxiolytic behavior in cAD rats than that of naproxen also may be supported by the observation that the total time spent in the outer area (parameter of anxiety) in cAD rats regains the level of control by administration of etoricoxib at the dose of 20 mg/kg body weight on day 14, whereas it did not regain the control value with naproxen at the same dose and time point. The better protection of anxiolytic behavior by etoricoxib in comparison to naproxen may be due to the dual inhibitory action of etoricoxib on the expression and activity of cox-2 [ 33 , 34 ], while naproxen can only inhibit both the cox-1 and cox-2 activity but not their expression [ 35 , 36 ]. Since inducible cox-2 expression and activity were increased during neuroinflammation [ 37 ], the blocking of this enzyme expression and activity by etoricoxib [ 33 , 34 ] in the present study probably inhibited neuroinflammation, and as a result neurodegeneration was also inhibited in these rats.…”

Section: Discussionmentioning

confidence: 99%

“…The better protection of anxiolytic behavior by etoricoxib in comparison to naproxen may be due to the dual inhibitory action of etoricoxib on the expression and activity of cox-2 [ 33 , 34 ], while naproxen can only inhibit both the cox-1 and cox-2 activity but not their expression [ 35 , 36 ]. Since inducible cox-2 expression and activity were increased during neuroinflammation [ 37 ], the blocking of this enzyme expression and activity by etoricoxib [ 33 , 34 ] in the present study probably inhibited neuroinflammation, and as a result neurodegeneration was also inhibited in these rats. Therefore, the role of cox-2 on the colchicine induced anxiolytic behavior was emphasized from this study.…”

Section: Discussionmentioning

confidence: 99%

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Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

Sil

Ghosh

2016

Behavioural Neurology

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The anxiety status is changed along with memory impairments in intracerebroventricular colchicine injected rat model of Alzheimer Disease (cAD) due to neurodegeneration, which has been indicated to be mediated by inflammation. Inducible cox-2, involved in inflammation, may have important role in the colchicine induced alteration of anxiety status. Therefore, the present study was designed to investigate the role of cox-2 on the anxiety behavior (response to novelty in an elevated open field space) of cAD by inhibiting it with three different doses (10, 20, and 30 mg) of etoricoxib (a cox-2 blocker) in two time points (14 and 21 days). The results showed anxiolytic behavior in cAD along with lower serum corticosterone level, both of which were recovered at all the doses of etoricoxib on day 21. On day 14 all of the anxiety parameters showed similar results to that of day 21 at high doses but not at 10 mg/kg body weight. Results indicate that the parameters of anxiety were dependent on neuronal circuitries that were probably sensitive to etoricoxib induced blocking of neurodegeneration. The present study showed that anxiolytic behavior in cADr is predominantly due to cox-2 mediated neuroinflammation induced neurodegeneration in the brain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

Sil

Ghosh

2016

Behavioural Neurology

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Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study

et al. 2013

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The most common cause of laryngitis is the laryngopharyngeal reflux disease. The symptoms of laryngitis can be hoarseness, globus, chronic cough, voice fatigue, throat pain, and dysphagia. Low-level laser therapy (LLLT) is beneficial to reduce the pain and inflammatory response without side effects. Therefore, LLLT may be a useful tool for the treatment of laryngitis. This study proposes to analyze the effect of laser therapy in a model of reflux-induced laryngitis. The animals were randomly put into three groups: control--non-intubated; nasogastric intubation--intubated; and nasogastric intubation with laser therapy-intubated treated with 105-J/cm(2) laser irradiation. For the induction of laryngitis, the animals were anesthetized and a nasogastric tube was inserted through the nasopharynx until it reached the stomach, for 1 week. Thereafter, measurement of myeloperoxidase activity and the histopathological procedures were performed. In conclusion, we observed in this study that 105-J/cm(2) infrared laser reduced the influx of neutrophils in rats, and it improved the reparative collagenization of the laryngeal tissues.

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Effect of pH and α-, β- and γ-cyclodextrin on the spectral properties of etoricoxib: spectroscopic and molecular dynamics study

Yousef

Ghanem

Alshraa

et al. 2017

J Incl Phenom Macrocycl Chem

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The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment

Abstract: Etoricoxib is effective in neurogenic laryngitis for limited periods of administration, indicating that selective COX-2 inhibitors should be evaluated in the future.

Cited by 8 publications

References 37 publications

Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study

Effect of pH and α-, β- and γ-cyclodextrin on the spectral properties of etoricoxib: spectroscopic and molecular dynamics study

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