Demonstrated Efficacy of a Pilot Heterologous Whole-Spore Vaccine against Microsporidial Gill Disease in Rainbow Trout

Harkness, Jennifer E.; Guselle, Nicole

doi:10.1128/cvi.00340-13

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Microsporidia have been responsible for the collapse of fisheries, and they have also been implicated in honey bee colony collapse disorder, a disease that is decimating the honey bees that pollinate many essential crops. Recently, progress has been made in developing vaccines and cell lines for study of fish infections by microsporidia [10-14]. Due to space limitations, we direct the reader to existing reviews of microsporidia infections and treatments in fish [15,16], and in honey bees [17].…”

Section: Introductionmentioning

confidence: 99%

Microsporidia–host interactions

Szumowski¹,

Troemel²

2015

Current Opinion in Microbiology

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Microsporidia comprise one of the largest groups of obligate intracellular pathogens and can infect virtually all animals, but host response to these fungal-related microbes has been poorly understood. Several new studies of the host transcriptional response to microsporidia infection have found infection-induced regulation of genes involved in innate immunity, ubiquitylation, metabolism, and hormonal signaling. In addition, microsporidia have recently been shown to exploit host recycling endocytosis for exit from intestinal cells, and to interact with host degradation pathways. Microsporidia infection has also been shown to profoundly affect behavior in insect hosts. Altogether, these and other recent findings are providing much-needed insight into the underlying mechanisms of microsporidia interaction with host animals.

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