Demographics of Men and Minorities in Cosmetic Clinical Trials of Botulinum Toxin and Hyaluronic Acid Fillers

Roman, Jorge; Zampella, John G.

doi:10.1097/dss.0000000000002294

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…50 Moreover, in a justpublished meta-analysis of 41 clinical trials on nonsurgical cosmetic procedures, women accounted for 88.2% of all patients. 51 Unfortunately, but consistent with their disproportionate representation among CS patients, most published studies on attitudes toward and predictors of CS have been restricted to all-female 8,9,38,41,43,44,52,53 populations, with a few others restricted to men. 23,54,55 In the few studies in which women and men were compared directly, women have tended to be more knowledgeable of CS than men, 13 and generally be more accepting.…”

Section: Gendermentioning

confidence: 99%

Demographic and Cultural Differences in the Acceptance and Pursuit of Cosmetic Surgery: A Systematic Literature Review

Alotaibi

2021

Plastic and Reconstructive Surgery - Global Open

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Background: Worldwide, the numbers of cosmetic procedures continue to climb. However, cosmetic surgery (CS) continues to be plagued by negative stigmatization. This study reviews the literature to identify how attitudes toward CS vary by sex, age, race, culture, and nationality, and aims to determine how other factors like media exposure interact with demographics to influence how well CS is accepted. Methods: A PRISMA-guided systematic review of the literature was conducted to identify all English-language papers reporting on CS or plastic surgery acceptance, attitudes, or stigmatization, specifically examining for data on age, sex, race/ethnicity, culture, and media influence. Results: In total, 1515 abstracts were reviewed, of which 94 were deemed pertinent enough to warrant a full-text review. Among the potential demographic predictors of CS acceptance, the one with the most supportive data is sex, with women comprising roughly 90% of all CS patients in virtually all populations studied and consistently exhibiting greater CS knowledge and acceptance. Culturally, the pursuit of beauty through CS is a universal phenomenon, although different countries, races, and cultures differ in how willingly CS is embraced, and in the aesthetic goals of those choosing to have it. In countries with culturally diverse societies like the United States, non-Hispanic Whites continue to predominate among CS patients, but the number of CS patients of other races is rising disproportionately. In this trend, social media is playing a major role. Conclusion: Healthcare practitioners performing cosmetic procedures need to consider demographic and cultural differences of the patients in order to enhance their understanding of their patients’ aesthetic goals and expectations.

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Section: Gendermentioning

confidence: 99%

Demographic and Cultural Differences in the Acceptance and Pursuit of Cosmetic Surgery: A Systematic Literature Review

Alotaibi

2021

Plastic and Reconstructive Surgery - Global Open

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“…Botulinum toxin and dermal fillers are the 2 most popular nonsurgical cosmetic procedures performed globally to treat age-associated changes and are often used in combination. 2 There are many kinds of filler materials for volume replacement and enhancement, such as hyaluronic acid (HA), 3 collagen, poly- l -lactic acid, 4 and calcium hydroxylapatite. 5 , 6 These fillers can be used for cheek and chin augmentation, nose reshaping, midface volumization, and lip enhancement.…”

mentioning

confidence: 99%

An Innovative Approach for Facial Rejuvenation and Contouring Injections in Asian Patients

Cui

Zhao

et al. 2021

Aesthetic Surgery Journal Open Forum

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An increasing number of Asian people are seeking nonsurgical facial aesthetic treatments. Ethnic Asians differ from Western populations in both facial appearance and baseline structural facial anatomy. And there is a lack of clinical instruction to doctors who provide facial aesthetic treatment for Asian patients. The authors proposed the “未来 Future Codes” design in Chinese calligraphy describing the art of facial injection in Asians to help doctors perform well. “未来” are pictograph of 2 Chinese characters, translated into English as “Future,” which represent beautiful meanings and vividly describe the procedure and operating area of the design methods. The concept encompasses a systematic overall design for the art of facial injection in Asians, and these procedures are easy to learn and perform safely. This is the first systematic solution available in the clinic that can be used to design facial aesthetics and rejuvenation in Asians through Eastern philosophy and culture. Level of Evidence: 5

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“…In a systematic review published in 2020, Roman and Zampella reported that men on average represented only 13.9% of all participants in the randomized controlled clinical trials conducted of botulinumtoxinA for cosmetic indications. 23 …”

mentioning

confidence: 99%

PrabotulinumtoxinA vs OnabotulinumtoxinA for the Treatment of Adult Males With Moderate to Severe Glabellar Lines: Post-hoc Analyses of the Phase III Clinical Study Data

Solish

Ascher²,

Avelar³

et al. 2022

Aesthetic Surgery Journal

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Background Despite evidence of a growing interest among men in minimally invasive cosmetic procedures such as botulinum toxin injections, comparator clinical trial data in this population are limited. Objectives To compare the efficacy and safety of prabotulinumtoxinA and onabotulinumtoxinA for the treatment of males with moderate to severe glabellar lines. Methods Post-hoc analyses were performed on the subpopulation of male patients treated with either a single dose of 20U prabotulinumtoxinA (n=25) or 20U onabotulinumtoxinA (n=31) in the EVB-003 single-dose Phase III glabellar line clinical study. One key efficacy endpoint was the proportion of responders with a ≥1 point improvement from baseline at maximum frown on the 4-point Glabellar Line Scale (GLS). Adverse events were also summarized. Results Compared with onabotulinumtoxinA-treated males, the percentages of responders who had a ≥1 point improvement on the GLS at maximum frown were higher at all post-baseline time points for prabotulinumtoxinA-treated males (p>0.05 at all visits), by an absolute overall mean difference of 10.1% across all visit. Similar trends were observed for efficacy endpoints based on global aesthetic improvement and subject satisfaction. PrabotulinumtoxinA-treated males had a higher incidence of treatment-related headache and eyelid ptosis. Conclusions The percentages of patients who met the definition of a responder were higher at almost all time points examined for prabotulinumtoxinA-treated males. Despite the high level of consistency across measures, differences between the two treatment groups did not reach statistical significance. Further study is warranted to establish whether observations based on these post-hoc analyses are reproducible in a larger male patient population.

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Demographics of Men and Minorities in Cosmetic Clinical Trials of Botulinum Toxin and Hyaluronic Acid Fillers

Cited by 10 publications

References 29 publications

Demographic and Cultural Differences in the Acceptance and Pursuit of Cosmetic Surgery: A Systematic Literature Review

Demographic and Cultural Differences in the Acceptance and Pursuit of Cosmetic Surgery: A Systematic Literature Review

An Innovative Approach for Facial Rejuvenation and Contouring Injections in Asian Patients

PrabotulinumtoxinA vs OnabotulinumtoxinA for the Treatment of Adult Males With Moderate to Severe Glabellar Lines: Post-hoc Analyses of the Phase III Clinical Study Data

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