Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study

Sharma, Namrata; Sinha, Gautam; Shekhar, Himanshu; Titiyal, Jeewan S; Agarwal, Tushar; Chawla, Bhavna; Tandon, Radhika; Vajpayee, Rasik B

doi:10.1136/bjophthalmol-2014-306008

Cited by 33 publications

(30 citation statements)

References 21 publications

(19 reference statements)

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“…However, in a prospective study in India conducted by Sharma et al [16], none of the eyes with Mooren's ulcer had a history of trauma or surgery as the inciting factors. In our study, there was no significant correlation between the recurrence of Mooren's ulcer and a history of ocular surgery or ocular trauma, whereas the significant correlation was found between the recurrence of Mooren's ulcer and a history of corneal infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Yang

Wang

Zhang

2017

Journal of Ophthalmology

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Purpose To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer. Methods We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 months. The difference between two groups was estimated. The patients in the recurrent group were subdivided according to the history of corneal infection and corneal perforation, respectively. The recurrent time in the subgroups was analyzed. Results Patients in the recurrent group were more likely to have a history of corneal infection and corneal perforation than that in the nonrecurrent groups. In patients with recurrent Mooren's ulcer, the median time to first recurrence was 130 days in the infection group, 480 days in noninfection group, and 195 days in the perforation group versus 480 days in nonperforation group. Conclusion Corneal infection and corneal perforation were associated with early recurrence of Mooren's ulcer. The tailored follow-up schedule should be used for patients with corneal infection and corneal perforation due to the high risk of recurrence.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Yang

Wang

Zhang

2017

Journal of Ophthalmology

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“…Unilateral disease occurs in 83.6% of cases. PUK has a male predominance (60%) with a third of patients reporting previous ocular surgery in the affected eye [89]. For patients with known RA, the mean disease duration was 20 years [87].…”

Section: Peripheral Ulcerative Keratitis (Puk) Epidemiologymentioning

confidence: 99%

Ocular Manifestations of Rheumatoid Arthritis: Implications of Recent Clinical Trials

Bhamra¹,

Gondal²,

Amarnani³

et al. 2019

Int J Clin Res Trials

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The variation in the reported rates of KCS can be attributed to factors such as: limited sample size, age of patients sampled, gender, subjective versus objective determination of DED. The association between RA and KCS is well established and contributes to morbidity [4][5][6]. Features and pathogenesisSymptoms of KCS include: burning, gritty sensation and dryness. A recent meta-analysis demonstrated a link between dry eye disease and depression and anxiety [7]. If left untreated, KCS may lead to a lidwiper epitheliopathy (analogous to that found in long-term contact lens wearer), keratitis, and possibly even opacification of the cornea [8]. In severe cases, one can see paracentral corneal melts which can cause permanent visual loss, and even perforation.Inflammation has been postulated as the underlying cause for KCS [9]. The pathogenesis of RA involves an inappropriate attack on the

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“…Corneal structural changes can be at the forefront of the systemic disease [6]. The clinical diagnosis and the follow-up of PUK remain challenging, supported by only a few publications [7].…”

Section: Introductionmentioning

confidence: 99%

Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

Bonnet¹,

Debillon²,

Al-Hashimi³

et al. 2020

BMC Ophthalmol

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Background: Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK. Methods: Retrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs, and AS OCT findings were the main outcomes. Results: The AS OCT findings were found to correlate with the ocular disease's level of activity. In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anterior stroma and a heterogeneous stromal reflectivity were observed. During the reduction of disease level activity, an irregular hyporeflective epithelium, a smoother anterior stroma, and a homogenous hyperreflective stroma were seen. At the healed stage, a filling of the corneal defect by a hyporeflective thick epithelium, the persistence of the hyperreflective underlying stroma, and a demarcation line were observed. The mean total corneal thickness at last follow-up was significantly thicker (509 ± 147 μm) compared with the mean corneal thickness at onset (408 ± 131 μm; P = 0.03). Conclusions: AS OCT provides an assessment of structural changes occurring in PUK, useful for its diagnosis and monitoring.

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Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study

Abstract: Mooren's ulcer followed by collagen vascular diseases and infection are important causes of PUK in developing countries. Surgical intervention in perforated cases had good anatomical success and visual prognosis.

Cited by 33 publications

References 21 publications

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Ocular Manifestations of Rheumatoid Arthritis: Implications of Recent Clinical Trials

Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

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