Demographic, clinical, laboratory and treatment characteristics of spondyloarthritis patients with and without acute anterior uveitis

Abstract

CONTEXT AND OBJECTIVE: Acute anterior uveitis is a common extra-articular manifestation in spondyloarthritis patients. The aim of this study was to compare demographic, clinical, laboratory and treatment data among spondyloarthritis patients with and without acute anterior uveitis. DESIGN AND SETTING: This was a cross-sectional analytical study at the Rheumatology Outpatient Clinic of the Evangelical University Hospital, Curitiba, Brazil. METHODS: Spondyloarthritis patients with without acute anterior uveitis were compared regarding demographic data, spondyloarthritis subtype, peripheral arthritis, enthesitis, disease activity, functional index, physical examination, radiological involvement, HLA-B27 and treatment. RESULTS: Presence of acute anterior uveitis was not found to have any relationship with functional index, degree of radiological involvement, peripheral arthritis or enthesitis. Acute anterior uveitis showed a negative association with skin manifestations (P = 0.04) and a trend towards higher disease activity (P = 0.06). CONCLUSION: In the study sample, it could not be shown that AAU had any association with the functional and radiological prognoses. The patients with spondyloarthritis with and without acute anterior uveitis did not differ clinically except for a higher proportion of ankylosing spondylitis and smaller presence of skin involvement in those with uveitis.reSUMO CONTEXTO E OBJETIVO: Uveíte anterior aguda é uma manifestação extra-articular comum em pacientes com espondiloartrite. O objetivo deste estudo foi comparar achados demográficos, clínicos, laboratoriais e de tratamento em pacientes com espondiloartrite com e sem uveíte anterior aguda. TIPO DE ESTUDO E LOCAL: Este é um estudo transversal analítico realizado no Ambulatório de Reumatologia do Hospital Universitário Evangélico de Curitiba, Brasil. MÉTODOS: Pacientes com espondiloartrite com e sem uveíte anterior aguda foram comparados quanto a dados demográficos, subtipo de espondiloartrite, artrite periférica, entesite, atividade da doença, índice funcional, exame físico, envolvimento radiológico, HLA-B27 e tratamento. RESULTADOS: Não se encontrou associação entre presença de uveíte anterior aguda e índice funcional, grau de envolvimento radiológico, artrite periférica e entesite. Encontrou-se uma associação negativa de uveíte anterior aguda com manifestações de pele (P = 0,04) e uma tendência para maior atividade de doença (P = 0,06). CONCLUSÃO: Na amostra estudada, não foi possível demonstrar associação entre uveíte anterior aguda no prognóstico funcional e radiológico. Pacientes com espondiloartrite com e sem uveíte anterior aguda não diferem clinicamente exceto por uma maior proporção de espondilite anquilosante e uma presença menor de envolvimento cutâneo naqueles com uveíte.

Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis / Anomalii ale axei CD147 solubil / MMPs / TIMPs la pacienții cu spondilită anchilozantă cu sau fără uveită acută anterioară

“…Consistent with the results of other groups of investigators (9,38,39,48), our data emphasize the existence of elevated values of BASDAI and BASFI in AAU AS patients suggesting that these patients develop a more aggressive disease than wAAU AS patients. For the first time, we identified MMP-2/sCD147 ratio as a new variable to better characterize AAU AS patients.…”

Clinical Spectrum of HLA-B27-associated Ocular Inflammation

“…44 The activity of uveitis is not necessarily correlated with the activity of systemic HLA-B27-associated disease. 45 The HLA-B27-associated AAU is typically unilateral and the intraocular inflammation usually lasts several weeks and diminishes within 3 months in the majority of patients. Occasionally, in severe cases, the time to remission may take longer than the 3 months, which is usually considered as a division border between acute and chronic forms of uveitis.…”

Radiographic Progression in Patients With Ankylosing Spondylitis According to Uveitis Based on the Observation Study of Korean Spondyloarthropathy Registry

“…One study has shown that history of uveitis is significantly associated with higher radiological score using Bath Ankylosing Spondylitis Radiology Index (BASRI). 16 On the other hand, Gehlen et al 5 have reported that BASRI scores are not significantly different between patients with or without uveitis (6.4±4.5 vs. 7.3±5.0, p=0.46) in a cross-sectional study. Chen et al 17 have also demonstrated that uveitis does not affect radiographic spinal involvement using both BASRI and mSASSS for patients in Taiwan.…”

“…4 Extra-articular manifestations of AS have also been frequently reported, with eyes being the most commonly involved. 5 Uveitis, inflammation of the anterior uvea containing iris and ciliary body, has been positively associated with disease progression of AS and occurs in 30 to 40% of patients with AS. [6][7][8] Symptoms of acute anterior uveitis (AAU) generally include an acute onset of eye redness and pain, intense photophobia, blepharospasm, and myosis that will eventually lead to reduction in visual acuity.…”