Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis / Anomalii ale axei CD147 solubil / MMPs / TIMPs la pacienții cu spondilită anchilozantă cu sau fără uveită acută anterioară

Mitulescu, Traian Costin; Voinea, Liliana; Predeţeanu, Denisa; Bănică, Leontina; Stăvaru, Crina; Matache, Cristiana

doi:10.2478/rrlm-2014-0039

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Recurrent episodes of uveitis were defined according to the same nomenclature: repeated episodes separated by periods of inactivity without treatment for more than 3 months. Patients were classified with SpA if they fulfilled either the 2009 ASAS criteria [ 1 , 2 ]: back pain for more than 3 months with onset before 45 years of age with either sacroiliitis on imaging (resonance magnetic imaging or conventional radiography) and at least 1 SpA feature (IBP, arthritis, heel enthesitis, uveitis, dactylitis, psoriasis, inflammatory bowel disease, good response to NSAIDs, family history of SpA, positive HLA-B27, elevated CRP) or positive HLA-B27 and at least two other SpA features.…”

Section: Methodsmentioning

confidence: 99%

“…The SpA group typically includes ankylosing spondylitis (AS), psoriatic arthritis, reactive arthritis, inflammatory bowel disease (IBD)-associated SpA and undifferentiated spondyloarthritis [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…The Assessment of Spondyloarthritis International Society (ASAS) proposed classification criteria for axial SpA patients [ 1 , 2 ]: patients aged less than 45 years with back pain for more than 3 months can be categorized with axial SpA if they have either sacroiliitis on imaging and at least one SpA feature, either HLA-B27 or at least two other SpA features. Sacroiliitis is defined either as bilateral grade 2–4 or as unilateral grade 3–4 sacroiliitis on standard radiographs, fulfilling the modified New York criteria [ 3 ], either sacroiliac bone marrow oedema/ osteitis on magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

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A referable clinical pattern of spondyloarthritis-associated uveitis

Mitulescu

Popescu

Oprea

et al. 2018

rjo

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Objective. The aim of the study was to identify a clinical pattern of spondyloarthritis (SpA)-associated uveitis in order to facilitate proper rheumatologic referral by ophthalmologists. Methods. Demographic data were recorded and acute phase reactants were measured using standard methods between May and August 2017, for all adult patients (age > 18 years) presenting with acute uveitis (standardization of uveitis nomenclature). Afterwards, they were referred to a rheumatology clinic to be screened for the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria of SpA. SpA and non-SpA patients were then compared using appropriate statistical tests (significant if p < 0.05). All the patients offered a written informed consent and the study was approved by the local ethics committee. Results. The sample included 67 subjects, of whom 32 (47.8%) were classified with SpA, of whom 21 were known with this diagnosis (median disease duration of 13.6 years), while 11 (34.4% of the SpA subgroup) fulfilled the ASAS classification criteria for SpA without a prior diagnosis. Compared to non-SpA patients, SpA patients were more frequently male urban dwellers, they were significantly younger, they had a higher prevalence of HLA-B27 and recurrent uveitis, and they had higher median of C-reactive protein and lower median of white blood counts. Conclusions. Uveitis is an important revelatory manifestation of SpA. Young men presenting in an ophthalmology department with acute anterior uveitis and inflammatory back pain should be referred to a rheumatology unit. Deviation, Spa = Spondyloarthritis, Tnfα = Tumour Necrosis Factor Alpha, WBC = White Blood Count.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A referable clinical pattern of spondyloarthritis-associated uveitis

Mitulescu

Popescu

Oprea

et al. 2018

rjo

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Identification of shared proteins between ankylosing spondylitis and its comorbidities through network biology

Bello,

Harun,

Aleng

et al. 2024

Netw Model Anal Health Inform Bioinforma

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Corneal confocal microscopy in the diagnosis of non-infectious etiology uveitis

2022

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Uveitis is one of the leading causes of blindness worldwide. Uveitis accounts for 10 to 15% of cases of complete vision loss and up to 35% of reversible vision loss. Particularly alarming is the fact that the debut of uveitis is recorded at a young working age. Uveitis includes a heterogeneous group consisting of at least 30 nosologies associated with various etiologies. The prognosis of the disease directly depends on the timely detection of its etiology. The review analyzes widely used methods for diagnosing patients with non-infectious uveitis. Special attention is paid to the advantages of confocal microscopy of the cornea, as the most modern non-invasive method that allows a detailed quantitative assessment of corneal subepithelial nerve plexuses and dendritic cells, the number of which increases during inflammatory processes, as well as a qualitative analysis of corneal precipitates and endothelial cells. Early detection of uveitis, which is an extra-articular manifestation of spondyloarthritis, allows appropriate treatment of severe systemic disease. It is assumed that the use of new approaches in the diagnosis of uveitis will prevent the development of severe complications up to complete loss of vision and improve the quality of life of patients.

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Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis / Anomalii ale axei CD147 solubil / MMPs / TIMPs la pacienții cu spondilită anchilozantă cu sau fără uveită acută anterioară

Cited by 3 publications

References 38 publications

A referable clinical pattern of spondyloarthritis-associated uveitis

A referable clinical pattern of spondyloarthritis-associated uveitis

Identification of shared proteins between ankylosing spondylitis and its comorbidities through network biology

Corneal confocal microscopy in the diagnosis of non-infectious etiology uveitis

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