Demographic, Clinical and Survivorship Characteristics of Males With Primary Cancer of the Breast

Keller, Andrew Z.

doi:10.1093/oxfordjournals.aje.a120682

Cited by 50 publications

(25 citation statements)

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“…Breast carcinoma has also been observed to be more common among American Jewish men, a population of predominantly Ashkenazi origin, compared to other non-Jewish Americans. (5)(6)(7)(8) The functionally defective mutations of BRCA1 and BRCA2 are associated with increased breast cancer risk; however, such mutations are relatively rare in unselected cancer patients. The frequency of three founder germline mutations in the tumor suppressor genes BRCA1 and BRCA2 among unselected Ashkenazi women with breast cancer is roughly 10%, and is much higher in multiple-case families.…”

Section: Introductionmentioning

confidence: 99%

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Chodick

Struewing

Ron

et al. 2008

European Journal of Medical Genetics

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To evaluate the potential contribution of mutations in the BRCA1 and BRCA2 genes to male breast cancer (MBC), we expanded a previous study to screen a total of 261 Israeli men diagnosed with breast carcinoma. A total of 21 BRCA2 6174delT and eight BRCA1 185delAG mutations were found. Similar frequencies of BRCA1 and BRCA2 mutation carriers were found among Ashkenazi (12.8%) and non-Ashkenazi Jews (9.1%). The combined prevalence of BRCA1/BRCA2 founder mutations among Ashkenazi Jewish men is slightly higher than for women, due to a higher frequency of BRCA2 mutations.

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Section: Introductionmentioning

confidence: 99%

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Chodick

Struewing

Ron

et al. 2008

European Journal of Medical Genetics

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“…A number of reports have described the clinical presentation and treatment of breast cancer in men as well as incidence and survival patterns. In some studies, increased age at diagnosis has been correlated with worse survival [3,4], while in others either the relative mortality from breast cancer was improved in older men [5], or no age effect was seen [6,7].…”

Section: Introductionmentioning

confidence: 99%

Racial differences in cancer of the male breast — 15 year experience in the Detroit Metropolitan Area

Simon

McKnight

Schwartz

et al. 1992

Breast Cancer Res Tr

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Characteristics of cancer of the male breast were evaluated in a population based review of 244 cases identified retrospectively through the Metropolitan Detroit Cancer Surveillance System (MDCSS) between 1973 and 1987. The mean age at diagnosis was 65 years and median survival time, 44 months. There were no apparent time trends in incidence for either white or black men from 1973 through 1987. Modified radical mastectomy was the most common surgical procedure, while simple and radical mastectomy declined in popularity over time. Cox's proportional hazards regression model was used to test the simultaneous effects of age, race, stage, and treatment on survival. Men older than 65 at diagnosis had a greater risk of dying than men under 65 (RR 1.52, 95% confidence interval, 1.01-2.28). Survival was significantly worse for men who presented at a more advanced stage; regional versus localized (RR 2.19, 95% confidence interval, 1.39-3.45) and remote versus localized (RR 4.31, 95% confidence interval 2.26-8.23). Race had no significant effect on survival in men with breast cancer in the Detroit Metropolitan Area.

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“…Male breast cancer has been described world-wide, and the incidence is, compared to that of female breast cancer, slightly higher in the UK and Northern Ireland than in Japan or Finland [8]. Keller [9] could not show any relationship between the inci dence of male breast cancer and race, geographical region, marital status, employment situation and religion. Schottenfeld et al [10] demonstrated a higher morbidity for non-Cau casian patients as well as an unevenly distributed morbidity with higher figures in the east, central and southern states.…”

Section: Epidemiologymentioning

confidence: 88%

Male Breast Cancer

Schon¹,

Zaiac²,

Schlag³

1995

Oncol Res Treat

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Male breast cancer represents with 1.5% of male malignancies a rare disease. Compared to the vast amount of data and knowledge in female breast cancer, male breast cancer is less well-researched and explored. Potential risk factors are oestrogen (exogenous or endogenous), gynaecomastia, radiation, exposure to heat and the Klinefelter’s syndrome. Whereas female breast cancer shows a double-peak risk distribution, the risk for males to develop breast cancer increases linearly with age. Bilateral male breast cancer is extremely rare. All kinds of histological tumour types described in female patients were observed in male breast cancer too. The prognosis for male breast cancer is, if at equal stage, comparable to that of female breast cancer. Similar as in their female counterparts, survival of the male patients depends on tumour size and axillary lymph node status, and because of this it depends on an early diagnosis. Oestrogen and progesterone receptor status, however, are of lesser prognostic significance in male breast cancer. Therapeutic advances were analogous to the treatment of female breast cancer. Besides the introduction of less radical surgical procedures, hormonal ablative surgical procedures were replaced by medical therapy. Tamoxifen therapy in nodal-positive patients of tumour stages II and III resulted in 5-year survival rates of 60 to 85%. Even in patients showing distant metastases, response rates of 40 to 60% can be obtained by applying the different chemotherapeutic strategies for female breast cancer patients.

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Demographic, Clinical and Survivorship Characteristics of Males With Primary Cancer of the Breast

Cited by 50 publications

References 0 publications

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Racial differences in cancer of the male breast — 15 year experience in the Detroit Metropolitan Area

Male Breast Cancer

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