Racial differences in cancer of the male breast — 15 year experience in the Detroit Metropolitan Area

Simon, Michael S.; McKnight, Elizabeth; Schwartz, Ann G.; Martino, Silvana; Swanson, G. Marie

doi:10.1007/bf01811964

Cited by 19 publications

(20 citation statements)

References 20 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This concurs with geographical variations in MBC rates in other populations, showing rates to be greatest in Uganda and US blacks, high in Israelis Jews, slightly lower in European and US whites, and least in Asians and Central and South Americans [16]. The AARs we present for whites and blacks are similar to those reported elsewhere [2,12]. Black race has been associated with greater incidence of MBC both within multiethnic societies and across countries with differing racial compositions [2,12,17,18].…”

Section: Discussionsupporting

confidence: 90%

“…The AARs we present for whites and blacks are similar to those reported elsewhere [2,12]. Black race has been associated with greater incidence of MBC both within multiethnic societies and across countries with differing racial compositions [2,12,17,18]. This may be due to yet unidentified genetic differences, given that positive family history, germline mutations of BRCA2 and Klinefelter's syndrome have all been previously associated with MBC [4,18,19].…”

Section: Discussionsupporting

confidence: 79%

“…No increased incidence over time was found for 1456 men in a 1992-2000 SEER study [2], while a Florida study of 1396 men noted a significant increase in incidence from 0.9/100,000 in 1990 to 1.5/100,000 in 2000 [30]. A smaller study of men reported to the Detroit SEER registry reported stable rates for both blacks and whites [12]. Studies spanning 40 years in the second half of the 20th century report increasing rates in Icelandic and Danish men, but not in Swedes, Norwegians or Finns [31,32]; no increase was reported in 25 European countries during a similar time period [33].…”

Section: Discussionmentioning

confidence: 70%

“…Furthermore, when tumor size alone was evaluated, blacks and Hispanics had significantly larger tumors than men in the other two racial/ethnic categories. In Detroit, black males were more likely than whites to present with advanced disease, but the differences were not statistically significant [12]. Previous studies reported larger tumors [2] and later stage at diagnosis in blacks compared to whites [34], but data on stage at diagnosis for Hispanics and Asians have not been available.…”

Section: Discussionmentioning

confidence: 95%

“…Age-adjusted incidence rates are greatest in white women, intermediate in blacks and lesser in Hispanics and Asians [11]. An early study from the Detroit component of the Surveillance, Epidemiology and End Results (SEER) program found a greater incidence of MBC and more advanced stage at diagnosis in black men than in white [12]. The greater incidence in blacks was confirmed in a recent SEER-wide study, which also reported that black men had more aggressive tumors [2].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Incidence of Male Breast Cancer in California, 1988–2000: Racial/Ethnic Variation in 1759 Men

O’Malley

Shema

White

et al. 2005

Breast Cancer Res Treat

View full text Add to dashboard Cite

Breast cancer among males is rare, accounting for less than 1% of all breast cancers in the United States. Although it is rare, it can cause significant morbidity and mortality. We analyzed data from 1759 California males whose diagnosis of breast cancer was made between 1988 and 2000 and reported to the population-based California Cancer Registry. Cases were primary, microscopically confirmed in situ and invasive breast cancer. Age-adjusted incidence rates per 100,000 men were highest in Blacks (1.65), intermediate in whites (1.31) and lowest in Hispanics and Asian/Pacific Islanders (0.68, 0.66, respectively). Age at diagnosis differed by race (p = 0.001) with blacks diagnosed at an earlier age than whites or Asians/Pacific Islanders. Stage at diagnosis also differed by race (p = 0.001) with blacks more likely to be diagnosed at distant stage. Further investigation showed that blacks and Hispanics were more likely to be diagnosed with tumors 5 cm in diameter or greater. The proportion of men having surgery following a diagnosis of breast cancer also varied by race/ethnicity (p = 0.001) with blacks least likely to have surgery following diagnosis. Understanding racial/ethnic variation in male breast cancer may provide clinical and etiologic implications for breast cancer in different populations.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence of Male Breast Cancer in California, 1988–2000: Racial/Ethnic Variation in 1759 Men

O’Malley

Shema

White

et al. 2005

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

Male breast cancer in Iceland

et al. 1996

View full text Add to dashboard Cite

These occurred in slightly older patients than the infiltrating ductal carcinomas and were diploid tumours. In this study 57% of the tumours were found to be aneuploid, but nearly 70?? of the invasive ductal carcinomas NOS were aneuploid. In general, the aneuploid tumours were larger, of higher average histological grade and had a higher mean S-phase value. The overall mean S-phase fraction was 7.2v0 which is similar to that found in female breast tumours in Iceland. It is concluded that the male-to-female ratio of breast carcinoma in Iceland is similar to that found in other Western countries. The age-standardised incidence has increased considerably in the last 20 years, in contrast to the rates reported from most other countries. Papillary tumours are unusually common in Icelandic males.o 1996 Wiley-Liss, Inc.Carcinoma of the vestigial male breast is rare. The male-tofemale ratio of breast cancer varies geographically, being about 1% in the Western countries (Hecht and Winchester, 1994). The ratio is significantly higher in some parts of Africa, and in Blacks in the Western countries (Bhagwandeen, 1972;El-Gazayerli and Abdel-Aziz, 1963; Simon et al., 1992).In recent years, epidemiological reports on tumours of the male breast in Scandinavia (Adami et al., 1989; Ewertz et al., 1989) and in most European countries (La Vecchia et al., 1992) have been published. Iceland was not included in these studies because of the small population (a quarter of a million people). No reports on the epidemiology and histological variables of carcinoma of the male breast in Iceland have previously been published.The purpose of this work is to report on all male breast cancers diagnosed in the 40-year time period 1955-1994 in Iceland. Epidemiological data are presented with histopathological classification of the tumours, histological grading and the results of DNA-analysis by flow cytometry.Very little has been published on ploidy and S-phase fraction in tumours of the male breast to date (Gattuso et al., 1992; Hatschek et al., 1994) in contrast to the extensive literature on the subject in the female breast cancer. This report compares the histological typing, tumour grading and results of flow cytometry in male breast cancer to what has been observed in malignant breast tumours of females in Iceland. MATERIAL AND METHODSInformation concerning male patients diagnosed with breast carcinoma in Iceland during the 40-year period 1955-1994 was obtained from the Icelandic Cancer Registry. After histological and clinical revision, malignant breast tumours were diagnosed in a total of 31 patients. All histological slides, including at least one re-cut H. and E.-stained section, were reviewed by 2 of the authors (J.G.J. and B.A.A.).All carcinomas were classified into main histologic groups according to the World Health Organisation Classification (1981). All carcinomas of the infiltrating ductal type NOS were graded according to the Bloom and Richardson method with the Nottingham/Tenows modification (Elston, 1987). Patient's age at di...

show abstract

Racial/ethnic differences in survival rates in a population‐based series of men with breast carcinoma†

O’Malley

Prehn

Shema

et al. 2002

Cancer

View full text Add to dashboard Cite

BACKGROUND A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates in 1979 men diagnosed with primary invasive breast carcinoma between 1973 and 1997. Race was defined as non‐Hispanic white, non‐Hispanic black, and other race/ethnicity (predominantly Asian/Pacific Islander and Hispanic). The two outcomes were all‐cause and breast carcinoma‐ specific mortality. Survival curves were drawn using Kaplan–Meier estimates and Cox regression was used to estimate the risk of death with hazard ratios and 95% confidence intervals. For both outcomes, the racial/ethnic survival curves differed significantly when the log rank test was used. Therefore, separate models were run for each racial/ethnic group. Covariates included age, stage, histology, surgery, radiation therapy, and year of diagnosis. Estrogen and progesterone receptor status were available for 616 men. RESULTS Survival rates differed significantly by race/ethnicity. Overall, 5‐year survival rates were 66% for whites, 57% for blacks, and 75% for men of other race/ethnicity. Blacks presented with more advanced disease. By stage, whites and blacks had worse survival rates compared with men of other race/ethnicity. The effects of prognostic factors such as age, surgery type, and radiation were similar, but not always significant, for all groups. Diagnosis year and estrogen receptor status did not affect survival. CONCLUSIONS Survival following male breast carcinoma differed by race/ethnicity, whereas the prognostic factors associated with survival were similar. Cancer 2002;94:2836–43. Published 2002 American Cancer Society. DOI 10.1002/cncr.10521

show abstract

Racial differences in cancer of the male breast — 15 year experience in the Detroit Metropolitan Area

Cited by 19 publications

References 20 publications

Incidence of Male Breast Cancer in California, 1988–2000: Racial/Ethnic Variation in 1759 Men

Incidence of Male Breast Cancer in California, 1988–2000: Racial/Ethnic Variation in 1759 Men

Male breast cancer in Iceland

Racial/ethnic differences in survival rates in a population‐based series of men with breast carcinoma†

Contact Info

Product

Resources

About