Demographic Characteristics and Clinico-Pathological Presentation of Breast Cancer Female Patients in South Egypt Cancer Institute (2005-2012)

Gabr, Adel

doi:10.18056/seci2016.7

Cited by 8 publications

(11 citation statements)

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“…10,12,24 A similar retrospective study performed on 1070 Egyptian breast cancer patients displayed that 18.7% were diagnosed before reaching 40 years, 79.5% were married, history of breast feeding, oral contraceptive pills, and breast cancer was noted in 73%, 39.5%, and 7.5% respectively while 62% presented in stages III and IV. 31 In India, the median age at presentation in a survey including 1528 breast cancer patients was 49 years, 69.6% were postmenopausal, family history of breast cancer was positive in 4.2%, the most common symptom was palpable lumps (96%) and 57% were diagnosed in stages III and IV disease. 32 On the other hand, in Croatia, Europe, where breast cancer is the most common type of female malignancy, analysis of the demographic characteristics and reproductive findings belonging to 870 female patients showed that the mean age was 69 years; <2% were younger than 35 years.…”

Section: Discussionmentioning

confidence: 99%

Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq

Alwan

Tawfeeq

Mallah

2019

J. Contemp. Med. Sci.

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Objective To highlight the main demographic characteristics and clinical profiles of female patients registered with breast cancer in Iraq; focusing on the impact of age.Methods This retrospective study enrolled 1172 female patients who were diagnosed with breast cancer at the Main Center for Early Detection of Breast Cancer/Medical City Teaching Hospital in Baghdad. Data were extracted from an established information system, developed by the principal author under supervision of WHO, that was based on valid clinical records of Iraqi patients affected by breast cancer. The recorded information regarding clinical examination comprised positive palpable lumps, bloody nipple discharge, skin changes, bilateral breast involvement, tumor size, lymph node status, and the stage of the disease.Results The mean age at the presentation was 51 years; patients under the age of 50 constituted 46.8%. Overall 9.8% were not married, 22.4% were illiterate whereas 19.2% graduated from universities. About 72% of the patients had more than two children, merely 7.5% delivered their first child after the age of 35 years and only 11% were nulliparous. History of lactation and hormonal therapy was recorded in 57.6% and 19.4% respectively. Family history of cancer was positive in 28.8% and breast cancer specifically in 18.7%. Clinically, the most common presenting symptom was breast lumps (95%) followed by skin changes/ulcerations (6.7%) and bloody nipple discharge (4.3%).Bilateral breast involvement was encountered in 4.7%. More than two-thirds of the patients (68.2%) had palpable axillary lymph nodes; classifying 40.5% into advanced stages III and IV. In general stages Iâ€“IV comprised 12%, 47.5%, 31.9%, and 8.6% respectively. Upon stratifying the studied sample with respect to age at diagnosis, it was observed that the frequency of unmarried patients was significantly higher among younger women under the age of 50 years, whereas illiteracy and nulliparity features were statistically lower (p < 0.05).Conclusion A considerable proportion of breast cancer patients in Iraq still present with locally advanced disease at the time of diagnosis. That justifies the necessity to promote public awareness educational campaigns to strengthen our national early detection program. Excluding the marital status, level of education and number of parity, there was no statistical difference regarding the impact of age on the demographic and clinical profiles of breast cancer among premenopausal versus postmenopausal Iraqi patients.

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Section: Discussionmentioning

confidence: 99%

Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq

Alwan

Tawfeeq

Mallah

2019

J. Contemp. Med. Sci.

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“…22 While the ER+/PR+ phenotype was recorded in 75% of our studied patients, the ER-/PR-variant 17.5%, the ER+/PR-5% and the ER-/PR+ 2.5%. Gabr et al, (2016) reported that the ER+/PR+ phenotype was recorded in 40.6% of the studied population, the ER-/PR-variant displayed in 30.4%, and ER/PR undetermined in 20%. 17 HER2 is a growth-promoting protein on the outside of all breast cells.…”

Section: Discussionmentioning

confidence: 89%

“…The mean age of BC patients in this study was (51.53 ± 1.95) years; this is in accordance with Gabr et al ( 2016) who reported that two third of the patients were between their forties and sixties, displaying a noticeable decline after the age of 60 years. 17 World Health Organization (WHO) estimates revealed that half of the cancers in the Eastern Mediterranean Region (EMR) occur before the age of 55 years. 18 In this study BC involves left side (LS) more than right side (RS) with LS-to-RS ratio (LRR) of 1.35.…”

Section: Discussionmentioning

confidence: 99%

Frequency of regulatory B cells phenotypes in breast cancer patients in Egypt

Elgendy

El-Sabaa

Ahmed

et al. 2021

EJI

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Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of the anti-tumor activity, however; the role of regulatory B cells (B-regs) in breast cancer (BC) remains unclear. This study intended to assess the frequency of peripheral B-regs phenotypes in patients with BC, and to determine the relation between these phenotypes and the patient’s clinicopathological characters. The expressions of the immune cell populations were analyzed by four-color flow cytometry in 40 naïve BC patients and 10 age-matched apparently healthy individuals as controls attending the department of Clinical Oncology and Nuclear Medicine at Assiut University Hospitals. The percentages of B-regs phenotypes CD19+IL10+ and CD19+CD24hiCD27+IL10+ were higher in BC patients than in the controls. The percentage of CD19+IL10+ B cells phenotype was significantly associated with the HER-2 expression levels, T, and N stages of BC. In conclusion, high percentage of B-regs phenotypes CD19+IL10+ and CD19+CD24hiCD27+IL10+ in BC patients indicates a possible role in immune suppression during the development of BC.

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“…Approximately one third of breast cancer patients are diagnosed at the age of 40-50 years (mean age range 49 (26-86)); 71% are from rural areas; Positive family history was noted in 7.5%. The patient himself detected a lump in the majority of cases (84%), (Gabr, 2016). In addition to environmental causes, family history has also emerged as an important risk factor in the etiology of this disease (Tazzite, Jouhadi, Saiss, Benider, & Nadifi, 2013).…”

Section: The Relationship Between Heredity and Cancer Riskmentioning

confidence: 99%

Breast Cancer Risk Prevention Model (RICANDRA) to Determine the Risk Factors Associated with the Incidence of Breast Cancer in Women of Childbearing Age in Lampung Province

Aprina

Astuti

2022

J. Sci. n.a

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Breast cancer in Indonesia is at the top of the list that occurs in women. Most breast cancer conditions are known to be in an advanced stage. Detection at this advanced stage has a very poor prognosis, because at this stage cancer cells have spread more widely and faster than when cells were detected in an early stage. Objectives of this study to determine the risk factors associated with the incidence of breast cancer in women of childbearing age in Lampung Province and to develop a breast cancer risk prevention model (RICANDRA). This type of research is quantitative with a cross sectional design. This research was conducted from March to December 2019 in Lampung Province. The target of this study were all women of childbearing age, a sample of 458 women of childbearing age with purposive sampling. The objects taken are advanced age, first child born at the age of > 30 years, close family ties/hereditary, history of breast tumor, previous diagnosis, early menstruation, late menopause, use of hormones for menopausal symptoms, exposure to radiation, history of cancer, use of contraceptives hormones, obesity and stress. Collecting data using checklist sheets and questionnaires. Data analysis was univariate, bivariate (chi square) and multivariate. A total of 150 (32.8%) respondents were in the high-risk category and as many as 308 (67.2%) respondents were in the alert category. The results showed that the risk factors that influence breast cancer based on bivariate analysis were advanced age (OR = 5.869; 95% CI: 3.831-8.991; p = 0.000), the first child was born at the age of > 30 years (OR = 2.

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Demographic Characteristics and Clinico-Pathological Presentation of Breast Cancer Female Patients in South Egypt Cancer Institute (2005-2012)

Cited by 8 publications

References 0 publications

Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq

Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq

Frequency of regulatory B cells phenotypes in breast cancer patients in Egypt

Breast Cancer Risk Prevention Model (RICANDRA) to Determine the Risk Factors Associated with the Incidence of Breast Cancer in Women of Childbearing Age in Lampung Province

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