Demographic and Geographic Vascular Risk Factor Differences in European Young Adults With Ischemic Stroke

Putaala, Jukka; Yeşilot, Nilüfer; Waje‐Andreassen, Ulrike; Pitkäniemi, Janne; Vassilopoulou, Sofia; Nardi, Katiuscia; Odier, Céline; Hofgárt, Gergely; Engelter, Stefan T.; Burow, Annika; Mihálka, László; Kloß, Manja; Ferrari, Julia; Lemmens, Robin; Çoban, Oğuzhan; Haapaniemi, Elena; Maaijwee, Noortje A.M.; Rutten-Jacobs, Loes C.A.; Bersano, Anna; Cereda, Carlo; Baron, Pierluigi; Borellini, Linda; Valcarenghi, Caterina; Thomassen, Lars; Grau, Armin J.; Palm, Frederick; Urbanek, Christian; Tunçay, Rezzan; Durukan-Tolvanen, Aysan; Dijk, Ewoud J. van; Leeuw, Frank‐Erik de; Thijs, Vincent; Greisenegger, Stefan; Vemmos, Konstantinos; Lichy, Christoph; Bereczki, Dániel; Csiba, László; Michel, Patrik; Leys, Didier; Spengos, Konstantinos; Næss, Halvor; Bahar, S.; Tatlısumak, Turgut

doi:10.1161/strokeaha.112.662866

Cited by 137 publications

(138 citation statements)

References 34 publications

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“…A very similar profile of classic vascular risk factors in young ischemic stroke patients has also been reported elsewhere, however, differing in the order of frequency [3][4][5][6][7][15][16][17][18][19]. These results show that conventional vascular risk factors are significant risk factors for ischemic stroke not only in the >55 age group, but also in younger population.…”

Section: Discussionsupporting

confidence: 87%

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

Supanc¹,

Sonicki

Vukasović³

et al. 2014

Journal of Stroke and Cerebrovascular Diseases

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Section: Discussionsupporting

confidence: 87%

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

Supanc¹,

Sonicki

Vukasović³

et al. 2014

Journal of Stroke and Cerebrovascular Diseases

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“…HT, DM, AF, and coronary artery disease were more common in our group of patients with ischemic stroke aged more than 45 years compared with the young group; however, in contrast to other studies, the patients were not compared with matched age groups. Few studies have determined stroke severity using baseline NIHSS score at hospital admission; baseline NIHSS score was reported as 3 in these studies (16,22). Our results demonstrated that baseline NIHSS score was 4.3±3.2 (0-12) in young patients ischemic stroke, and this figure was significantly lower than that of those aged more than 45 years (p=0.006).…”

Section: Discussionmentioning

confidence: 53%

“…Several studies have demonstrated that ischemic stroke in the young is more common among males (14,22), whereas other studies have identified no difference between males and females (16). In our study, we found no statistically significant difference in the rates of stroke between the male and female patients.…”

Section: Discussionmentioning

confidence: 99%

Etiologic Subtypes, Risk Factors And Outcome Of Acute Ischemic Stroke With Young Patients

Özer¹,

Sorgun²,

Rzayev³

et al. 2015

tnd

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Objective: Stroke in people aged less than 45 years is less frequent than in older patients, but has major impacts on both the individual and society. The aim of this study was to determine the etiologic subtypes of acute ischemic stroke in the young. Materials and Methods:We reviewed the hospital records of 619 patients who were admitted with acute ischemic stroke between January 2011 and November 2014. Acute ischemic stroke in the young was defined as patients aged 45 years and under. Demographic data, the National Institutes of Health Stroke Scale (NIHSS) scores at admission and detailed investigations aimed at determining etiologic cause were recorded. Etiologic stroke subtypes were determined using the automated Causative Classification System. Modified Rankin Scale (mRS) scores were recorded in the follow-up.Results: There were 32 (5.2%) young patients with acute ischemic stroke. The rates of hypertension, diabetes mellitus, atrial fibrillation, and coronary artery disease were significantly lower in young patients compared with patients aged more than 45 years (p<0.05). The mean NIHSS score at admission and hospital mortality was significantly lower in patients aged 45 years and under compared with those older than 45 years (p=0.006, p=0.043). Cardioaortic embolism was the most common etiologic stroke subtype in both groups. Other causes were significantly more frequent in the young acute ischemic stroke group compared with the older patients. The median follow-up mRS was significantly lower in patients aged 45 years and under compared with those older than 45 years (p<0.001). Conclusion:Young patients with ischemic stroke have different risk factors, stroke etiology, stroke severity and prognosis compared with patients older than 45 years with the same condition.

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“…There was a statistically significant difference when comparing female and male with hypertensive etiology of hemorrhagic stroke: the most hypertensive were men, presenting higher frequency of hemorrhagic stroke. In contrast, a study conducted in young adults who had suffered ischemic stroke from 15 European cities showed the relationship between smoking and dyslipidemia with the male 29, suggesting the need for preventive measures to avoid the occurrence and recurrence of stroke in this particular population 29 .…”

mentioning

confidence: 88%

Clinical and Functional Characteristics of Young Adult Patients Admitted in a Stroke Unit

Makhoul

Maso²,

Monteiro

et al. 2016

BJMHH

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A B S T R A C T BACKGROUND:Previously referred to as rare among young adults, in the last five years was found a frequency approaching 30 % of young adults between those who have suffered a stroke in Brazil. OBJECTIVE: To identify the sociodemographic, clinical and functional characteristics of young adult patients. METHODS: It was a cross-sectional study, conducted with individuals assisted in a stroke unit with ischemic or hemorrhagic stroke diagnosis and age of 18-50 years old between August 2014 to April 2015. It was used the National Institutes of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS). RESULTS: The study population consisted of 47 individuals, in which 28 (59,6%) were female, with an average age of 39,2 (DP±8,3) years, and brown skin color 21 (44,7%). They presented 8,9 years of formal education. 28 (59,6%) patients were diagnosed with ischemic stroke, 30 (63,8%) had involvement of the anterior circulation, and 23 (48,9%) of the left hemisphere. 26 (55,3%) patients presented hypertension and 36 (76,6%) were sedentary. The stroke severity had a median of 7 ( 0-23 ) points and 30 (63,7%) of patients the functional was capacity 5 in the Rakin Scale. It was found a statistically significant difference for hypertensive etiology of hemorrhagic stroke in men ( p = 0,047) when compared with gender and the occurrence of stroke in the right hemisphere in women (p=0,032). CONCLUSION: The profile of the young adult patients from a stroke unit consists of female, of brown skin color, economically active with moderate stroke severity and severe functional disability. According to the World Health Organization, the stroke is the second leading cause of death in the world, after ischemic heart disease¹. In Brazil and other Latin America countries it is the leading cause of death². The age group most commonly affected by stroke is between 70-80 years old due to the aging of nervous and cardiovascular system³ associated with risk factors such as diabetes, hypertension, smoking, physical inactivity, dyslipidemia, heart diseases², among others. Previously referenced as a rare condition among the young adults, with an incidence of 5 to 10% 4.5 , in Brazil, In the last five years have identified a frequency which is close to 40% of young adults between those who had stroke 6 . In addition to the high mortality rate, it is considered as the most disabling of long-term diseases, impacting not only the patient but also their families 7, and the social security and public system 8 . The growing number of young adults affected by stroke has increased the cost of disability benefits, greatly burdening the public health budget and being responsible for 40% of early retirements 8 . Furthermore, the great etiology diversity for stroke in the younger population, diverging from the elderly population in relation to the most important risk factors, topography and most affected vascular territories 9 justifies the need to extend studies on this population. The studies carried out in stroke units are not specific...

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Demographic and Geographic Vascular Risk Factor Differences in European Young Adults With Ischemic Stroke

Cited by 137 publications

References 34 publications

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

Etiologic Subtypes, Risk Factors And Outcome Of Acute Ischemic Stroke With Young Patients

Clinical and Functional Characteristics of Young Adult Patients Admitted in a Stroke Unit

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