Demographic and clinical profile of patients with brain metastases: A retrospective study

Abstract

Context:Brain metastases are the most common type of intracranial neoplasm, with the total number outnumbering primary brain tumors by a ratio of 10:1 and occur in about 25% of cancer patients. However, controversies exist regarding demographic and clinical profile of brain metastases.Aims:The purpose of this study was to analyze retrospectively the demographic and clinical profile of patients with brain metastases.Settings and Design:Retrospective, single institutional study.Materials and Methods:A retrospective study of 72 patients with brain metastasis was carried out from November 2010 to October 2012. The data pertaining to these patients was entered in a standardized case record form. These include History; clinical examination and other investigations including computed tomography/magnetic resonance imaging scan of the brain.Statistical Analysis:A statistical analysis was performed on the data collected using the MedCalc version 11.Results:Brain metastases were more common in male and occur in 6th decade of life mostly. There was no relationship of occupation or socio-economic status with the incidence of brain metastases. Carcinoma lung was the most common primary giving rise to brain metastases followed by breast. Adenocarcinoma accounts for most common histology of the primary that give rise to metastases. Multiple metastases were more common than the single group. Supratentorial lesions were more common than infratentorial lesions. Among them, parietal lobe was the most common site of involvement.Conclusions:The present study highlights that the incidence of brain metastasis is common in elderly population and mostly due to primary lung. Adenocarcinoma was the most common histology of primary. Majority of lesions has been observed at parietal lobe.

Histomorphological Spectrum of Central Nervous System Tumours- A Three-Year Retrospective Descriptive Study in a Tertiary Care Centre

“…15,16 Metastatic tumours account for 9.2% of all cases being common in elderly individuals above 50 years of age. The most common metastatic tumour was from lung similar to a study conducted by Sloan et al 17 and Saha et al 18 followed by metastasis from breast.…”

Survival of Brain Metastatic Patients in Yazd, Iran

“…In our study 11.2% and 12.6% of patients had only leptomeningeal involvement and leptomeningeal and parenchymal involvement respectively. In a large study that was carried out by Wolf et al (2013) in the US 35.6% of 1263 patients had single lesion, however the study of Saha et al (2013) which was performed in India 22.2% of the patients had single lesion. Maybe availability of more imaging facilities in the US and performing radiological studies earlier in cancerous patients could explain this difference.…”

“…In this study breast and lung cancer were the most common primary sites, too. Wolf et al (2013), Windsor (Windsor et al, 2013) et al andSaha et al (2013) in the US, Australia and India respectively showed that lung cancer is the most common primary site. This discrepancy maybe due to the fact that breast cancer is more prevalent in our country and in our province, too.…”

Predictive Factors of Survival Time of Breast Cancer in Kurdistan Province of Iran between 2006-2014: A Cox Regression Approach

“…The majority (n=24) of metastases was in bones. Brain metastasis accompanies with poor prognosis; without treatment, the patients will survive only about one month (Saha et al, 2013). Brain metastases were increased in recent years due to increased survival of cancer patients and widespread use of imaging modalities (Nicholas et al, 1766).…”