Demographic And Clinical Characteristics Of Men With Chronic Prostatitis: The National Institutes Of Health Chronic Prostatitis Cohort Study

Schaeffer, Anthony J.; Landis, J. Richard; Knauss, Jill; Propert, Kathleen J.; Alexander, Richard B.; Litwin, Mark S.; Nickel, J. Curtis; O’Leary, Michael P.; Nadler, Robert B.; Pontari, Michel A.; Shoskes, Daniel A.; Zeitlin, Scott I.; Fowler, Jackson E.; Mazurick, Carissa A.; Kishel, Lori; Kusek, John W.; Nyberg, Leroy M.

doi:10.1016/s0022-5347(05)64686-1

Cited by 196 publications

(133 citation statements)

References 13 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…About 50% of men suffer from this disease during their lifetime [8]. To date, the causes and mechanism of CP remain unknown, and treatment depends largely on experience and comprehensive medication.…”

Section: Discussionmentioning

confidence: 99%

Treatment of chronic prostatitis in Chinese men

Liang¹,

Li²,

Wang³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

The aim of this study is to assess the status of treatment of chronic prostatitis (CP) in Chinese men. A population-based cross-sectional survey was performed, in which 15 000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI) status, therapeutic efficacy and 28 other items. A total of 12 743 men (84.95%) completed the questionnaire, of whom 1 071 (8.4%) were identified as having prostatitis-like symptoms and 517 (4.5%) were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like symptomatology. Of the CP patients, 372 (65%) underwent long-term routine treatment 12 times per year. Additionally, 217 (72.8%) patients received antibiotic therapy and 215 (79.3%) men showed therapeutic effects. The treatment cost USD 1 151 (8 059 yuan) per person per year on average. Most CP patients received routine treatment, in most cases with antibiotics. Treatment was costly and most CP patients were not satisfied with its effectiveness. Antibacterial treatment might have been effective primarily in patients with bacterial disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Treatment of chronic prostatitis in Chinese men

Liang¹,

Li²,

Wang³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…The diagnosis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common in urologic practice, but its etiology is not understood and most biomedical treatments lack efficacy. 1 The prevalence of CP/CPPS is alarming among adults 2,3 and adolescents. 4 Males suffering from CP/CPPS report significant pain and diminished quality of life (QoL).…”

Section: Introductionmentioning

confidence: 99%

A feasibility trial of a cognitive-behavioural symptom management program for chronic pelvic pain for men with refractory chronic prostatitis/chronic pelvic pain syndrome

Tripp

Nickel

Katz

2013

CUAJ

Self Cite

View full text Add to dashboard Cite

Background: Our objective was to determine the feasibility of a cognitive behavioural symptom management program for the acute improvement of psychosocial risk factors of diminished quality of life (QoL) in men suffering from chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Materials and Methods:We assessed CP/CPPS symptoms and impact (i.e., chronic prostatitis symptom index [CPSI] pain, urinary, QoL domains), psychosocial risk factors were assessed at baseline and weekly for 8 weeks. We included the following psychosocial risk factors: catastrophizing (Pain Catastrophizing Scale, PCS), mood (Center for Epidemiological Studies in Depression Scale, CES-D), social support (Multidimensional Scale of Perceived Social Support, MSPSS) and general pain (McGill Pain Questionnaire). Patient sessions dispute and replace pessimistic thinking with health-focused thinking and behaviour. Results: Eleven men completed the psychosocial management program (mean age = 51.3, standard deviaton [SD] = 12.49). Mean CPSI baseline total score was 25.2 (SD = 10.21). Repeated measures ANOVAs showed the program was associated with significant linear reductions for pain (p = 0.051), disability (p= 0.020) and catastrophizing (p = 0.005), but no changes in depressive symptoms or social support. The CPSI baseline scores compared to follow-up scores (n = 8) were significantly reduced (p = 0.007), with CPSI pain (p = 0.015) and QoL impact (p = 0.013) reduced, but not for urinary scores. Correlations between change scores at the baseline and at 8 weeks for CPSI and psychosocial risk factors indicated that reductions in catastrophizing were most strongly associated with score reductions for the CPSI; these reductions, however, were not significant. Conclusions:The psychosocial management program targets and significantly reduces several empirically supported psychosocial risk factors associated with poorer CP/CPPS outcomes. Psychosocial management for CP/CPPS is feasible, but requires a randomized controlled trial with longitudinal follow-up.

show abstract

“…About 50% of men suffer from this disease during their lifetime. 1,2 The National Institutes of Health (NIH) consensus definition and classification identifies four categories of prostatitis:…”

Section: Introductionmentioning

confidence: 99%

Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

et al. 2010

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The purpose of this study was to assess the diagnostic value and potentially protective capacity of heat-shock protein 70 (HSP70) in chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In this study, seminal plasma levels of cytokines (tumor necrosis factor-a (TNF-a) and interleukin 1b (IL-1b)) and HSP70 were evaluated by enzyme-linked immunosorbent assay in 80 men: 15 healthy controls, 16 men with chronic bacterial prostatitis, 23 men with CP/CPPS IIIA and 26 with CP/CPPS IIIB. The HSP70 levels in chronic bacterial prostatitis and CP/CPPS patients were correlated with chronic prostatitis symptom index (CPSI). Significantly increased levels of cytokines (TNF-a and IL-1b) and HSP70 were observed in seminal plasmas from patients with chronic bacterial prostatitis compared with CP/CPPS patients and controls. However, only IL-1b was significantly elevated compared with CP/CPPS IIIB and controls in patients with CP/CPPS IIIA. HSP70 levels in CP/CPPS patients were significantly lower than that in controls. HSP70 concentration in seminal plasma was negatively correlated with CPSI in chronic bacterial prostatitis. The results indicated that HSP70 and IL-1b appear to be the most reliable and predictive surrogate markers to diagnose chronic bacterial prostatitis and CP/CPPS, respectively. HSP70 has an important protective role in the regulation of cell functions in chronic bacterial prostatitis. CP/CPPS would probably be detrimental to the ability of T cells and consequently suppress the expression of HSP70.

show abstract

Demographic And Clinical Characteristics Of Men With Chronic Prostatitis: The National Institutes Of Health Chronic Prostatitis Cohort Study

Cited by 196 publications

References 13 publications

Treatment of chronic prostatitis in Chinese men

Treatment of chronic prostatitis in Chinese men

A feasibility trial of a cognitive-behavioural symptom management program for chronic pelvic pain for men with refractory chronic prostatitis/chronic pelvic pain syndrome

Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

Contact Info

Product

Resources

About