Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

H, Guo; Ym, Xu; Zq, Ye; Yu, Jie; Fu, Qin; Yl, Sa; Xy, Hu; Lj, Song

doi:10.1038/pcan.2010.22

Cited by 19 publications

(12 citation statements)

References 38 publications

(29 reference statements)

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“…IL‐1β, TNF‐α, and HSP70 levels were increased in the seminal plasmas from patients with chronic prostatitis. In fact, increased IL‐1β in prostatic secretions has been suggested as a diagnostic indicator of chronic prostatitis . In this study, T. vaginalis stimulated the production of IL‐1β as well as CCL2 mRNA and CXCL8 mRNA in prostate epithelial cells.…”

Section: Discussionmentioning

confidence: 56%

Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis

Seo

et al. 2013

The Prostate

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Section: Discussionmentioning

confidence: 56%

Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis

Seo

et al. 2013

The Prostate

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“…In addition, patients with CP/CPPS had sperm quality alterations such as lower sperm concentration, motility and viability associated with elevated levels of IFNc, IL-17, IL-1b and IL-8, and more sperm apoptosis/necrosis. Cytokines such as tumour necrosis factor a, IL-1b, IL-6, and IL-8 have already been reported to be elevated in patients with CP/CPPS [42][43][44]. Moreover, IL-6 and IL-8 have been proposed as biomarkers of urogenital inflammation [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self‐reactive immune responses specific to prostate and seminal antigens and diminished semen quality

Motrich

Breser

Molina³

et al. 2020

BJU International

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Objectives To assess the presence of self‐reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract, and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Patients, Subjects and Methods Peripheral blood and semen samples were collected from patients with CP/CPPS and age‐matched healthy control volunteers. We analysed the lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) to different seminal plasma (SP)‐derived and purified PAg, serum autoantibodies specific to PAg, leucocyte subpopulations, and inflammatory cytokines in semen, sperm apoptosis/necrosis, and semen quality parameters. Results Significantly greater PBMC proliferative responses specific to PAg, with elevated secretion of interferon (IFN)γ and interleukin (IL)‐17, were detected in the patients with CP/CPPS vs the controls. Moreover, the patients with CP/CPPS had significantly greater serum immunoglobulin G immune reactivity to SP proteins, such as prostate‐specific antigen and prostatic acid phosphatase, than the controls. Inflammation of the male genital tract was exemplified by high levels of IFNγ, IL‐17, IL‐1β and IL‐8, as well as higher counts of leukocytes, mainly CD4 T lymphocytes and macrophages, in the semen. In addition, this local inflammation was associated with an overall diminished semen quality, i.e., reduced sperm concentration, motility and viability; and higher levels of sperm apoptosis/necrosis in patients with CP/CPPS vs controls. Conclusion Patients with CP/CPPS show T helper type 1 (Th1) and Th17 immune responses specific to PAg associated with chronic inflammation of the male genital tract and reduced semen quality. These immune responses may underlie the induction and development of chronic pelvic pain and inflammation of the male genital tract, which in turn could alter normal prostate functioning and impair semen quality.

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“…A®G replacement in 1267 position of HSP70-2 gene causes changes of mRNA HSP70 expression [22][23][24][25] . In some studies was proved that the HSP70 expression increasing is associated with higher activity of T-helpers, plays a protective role in regulation of cellular function in case of chronic pelvic pains and chronic bacterial prostatitis syndrome, block the tumour growth factor 1 production, decreasing inflammatory reaction and protects against bleomycin-induced pulmonary fibrosis in mice 26,27 . Our study is the first available of the HSP70-2 gene's A1267G SNP associations with the Escherichia enterocolitis.…”

Section: Discussionmentioning

confidence: 99%

Clinical markers of immune disorders in the pathogenesis of Escherichia coli enteritis

Sydorchuk¹,

Syrota²,

SYDORCHUK³

et al. 2019

Arch Balk Med Union

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Marqueurs cliniques des troubles immunitaires dans la pathogenèse de la coli entérite Introduction. La coli entérite est l'une des causes les plus courantes de diarrhée dans les pays développés et est généralement causée par des souches pathogènes d'Escherichia coli. Objectif: étudier le rôle de la réponse réactive des granulocytes neutrophiles polymorphonucléaires (GN) du sang périphérique dans les mécanismes de réponse inflammatoire systémique de l'entérocolite aiguë d'Escherichia (AEC) en fonction du polymorphisme des gènes de la protéine de choc thermique (HSP) de la famille 70-2 (HSP70-2, 1267A®G) et l'interleukine 10 (IL-10, C-592A). Méthodes. Le polymorphisme des gènes a été analysé par la méthode basée sur la PCR chez 95 patients avec AEC et 30 individus en bonne santé. Les marqueurs cliniques des troubles immunitaires ont été évalués à l'aide d'indices hématologiques, basés sur une analyse ABSTRACT Background. Escherichia coli enteritis is one of the most common causes of diarrhea in developed countries and is caused usually by pathogenic strains of Escherichia coli. Objectives. To investigate the role of reactive response of polymorphonuclear neutrophilic granulocytes (NG) of peripheral blood in the systemic inflammatory response mechanisms of acute Escherichia enterocolitis (AEC), depending on genes polymorphism of heat shock proteins (HSP) family 70-2 (HSP70-2, 1267A®G) and interleukin 10 (IL-10, C-592A). Material and methods. The genes polymorphism was analysed by PCR based method in 95 patients with AEC and 30 healthy individuals. Clinical markers of immune disorders were evaluated after hematological indices, based upon an extended general clinical blood analysis, using verified formulas. Results. The endogenous intoxication severity did not depend reliably on genotypes of IL-10 gene (rs1800872), however it was significantly 23.68%

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Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

Cited by 19 publications

References 38 publications

Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis

Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis

Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self‐reactive immune responses specific to prostate and seminal antigens and diminished semen quality

Clinical markers of immune disorders in the pathogenesis of Escherichia coli enteritis

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