“…This is of particular concern as high-performance computing architectures and smart algorithms are becoming widespread in e-health services: these advanced technologies need to be implemented with an ethical focus, such as making sensitive data anonymous and offering more checks or services to comply with legal framework and regulations, such as GDPR.This special issue is focused on advancements in digital technologies and IoT for e-health and medical supply chain systems. It contributes state-of-the-art research and applications in e-health records management, distribution, analysis, technology development and prototypes for ensuring efficiency, privacy and trust in real-world implementations, especially in large-scale computing environments.Through a careful review and selection process, the following articles have been included-they are all of the high quality and high academic rigour, and embody novel contributions, as per the Journal's standards.The first article, by Mydukuri et al (2022), proposes a novel technique known as least square regressive Gaussian neuro-fuzzy multi-layered data classification (LSRGNFM-LDC), which provides improved accuracy in COVID-19 early prediction based on various symptoms featuring in collected data. The technique performs with better accuracy and lower time consumption, with pre-processing applied to each input feature to eradicate irrelevant data.…”