Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics

Park, Mirae; Mah, Yonjoo; Kim, David-Hyungjin; Kim, Eunsuk; Park, Eun Jin

doi:10.1016/j.oooo.2015.05.021

Cited by 28 publications

(35 citation statements)

References 22 publications

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“…Yet, comparison between the results of new bone formation in (β-TCP) and Tooth ash groups in the present study; showed a significant increase in the amount of new bone formation all over the study period between the two study groups in favor of the tooth ash group. These findings came in accordance with Kim et al (6,9) , de Oliveira et al (15) , and Park et al (16) , as they attribute the high affinity of tooth ash in stimulating new bone formation to its composition. The main inorganic component is HA, that has an osteoconductive property, in addition to the osteoinductive effect of the organic component in case of autogenous tooth application (15,6,9,16) .…”

Section: Discussionsupporting

confidence: 90%

Histomorphometric Evaluation of the Healing Process of Bony Defects Filled with Milled Teeth Versus Beta Tri-Calcium Phosphate Bone Graft Materials in Rats.

Hassan

Elsaied

Ghali³

2020

Dental Science Updates

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The aim of the study was the evaluation of healing in bony defects comparing milled teeth versus beta tricalcium phosphate (B-TCP) as bone graft materials. Materials and methods: Forty-five male albino rats, were divided into three groups each group included 15 rats; one control and two experimental groups. Under general anesthesia, 1.5 cm incision was created to expose the cranial bone. Then two bone defects (each one with a diameter of 3 millimeter) were created one in each parital sides. In Group I (control group): the two bony defects (30 bony defects) were left to heal without any intervention. While, in Group II & III the bony defects were completely filled with (B-TCP) and milled teeth, respectively. At the 7 th , 15 th , and 30 days postoperatively five rates were randomly selected from each group to be sacrificed. Results: histomorophometric and histological results showed a higher level of bone regeneration in the two experimental groups than that of the control group all over the study period, moreover there was a significant increase in the amount of (newly formed bone) in the milled teeth than in the (B-TCP) group. The remaining particles of the two graft materials was significantly less in the milled teeth group than in the (B-TCP) group during the whole study time. Conclusion: Bone activity, formation and maturity were ahead in tooth ash filled calvarial bony defects.

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Section: Discussionsupporting

confidence: 90%

Histomorphometric Evaluation of the Healing Process of Bony Defects Filled with Milled Teeth Versus Beta Tri-Calcium Phosphate Bone Graft Materials in Rats.

Hassan

Elsaied

Ghali³

2020

Dental Science Updates

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“…Besides DDM particles, DDM blocks were also investigated [14,18,23,41,46]. In one study, DDM blocks with macropores were implanted into critical-sized iliac defects and new bone formation around the DDM had good union with the native bone [41].…”

Section: Ddm Preparationmentioning

confidence: 99%

Nano-Structured Demineralized Human Dentin Matrix to Enhance Bone and Dental Repair and Regeneration

et al. 2019

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Demineralized dentin matrix (DDM), derived from human teeth, is an excellent scaffold material with exciting bioactive properties to enhance bone and dental tissue engineering efficacy. In this article, first the nano-structure and bioactive components of the dentin matrix were reviewed. Then the preparation methods of DDM and the resulting properties were discussed. Next, the efficacy of DDM as a bone substitute with in vitro and in vivo properties were analyzed. In addition, the applications of DDM in tooth regeneration with promising results were described, and the drawbacks and future research needs were also discussed. With the extraction of growth factors from DDM and the nano-structural properties of DDM, previous studies also broadened the use of DDM as a bioactive carrier for growth factor delivery. In addition, due to its excellent physical and biological properties, DDM was also investigated for incorporation into other biomaterials design and fabrication, yielding great enhancements in hard tissue regeneration efficacy.

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“…Three properties are required for an ideal bone graft material: i) osteoconduction, which provides scaffolds for bone regeneration; ii) osteoinduction, which promotes the recruitment of bone-forming cells, such as undifferentiated cells and preosteoblasts, and formation of bone from these cells; and iii) osteogenesis, the induction of cells contained in the graft material to promote bone regeneration ( 7 ). Several bone graft materials have been used over time ( 8 ). Among them, autogenous bone is still considered the gold standard for bone augmentation because it exhibits all three properties ( 7 - 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…The rest 10% of the dentin matrix is formed by non-collagenous proteins (osteocalcin, osteonectin, sialoprotein and phosphoprotein) which are involved in bone calcification, and growth factors, including bone morphogenetic proteins (BMP), LIM mineralization protein 1 and insulin-like growth factors. This gives teeth an osteoinductive property ( 8 - 10 , 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

“…Koga et al ( 9 ) concluded in their in vitro study that PDDM with large particle (1000µm) has much more bone regenerative activity in comparison to UDD. This could be explained because demineralization enhances the osteoinduction capacity of tooth material by exposing organic substances within the teeth to the surface, increasing porosity and surface area, and decreasing crystallinity ( 8 ). Nevertheless, some authors have reported successful bone regeneration applying UDD ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

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Autogenous teeth used for bone grafting: A systematic review

Gual-Vaqués¹,

Polis-Yanes²,

Estrugo‐Devesa³

et al. 2017

Med Oral

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BackgroundRecently, bone graft materials using permanent teeth have come to light, and clinical and histological outcomes of this material have been confirmed by some studies. The aim of this systematic review was to evaluate the reliability of the autogenous tooth bone graft material applied to alveolar ridge augmentation procedures.Material and MethodsA systematic review of literature was conducted analyzing articles published between 2007 and 2017. The following four outcome variables were defined: a) implant stability b) post-operative complication c) evaluation of implant survival and failure rates, and d) histological analysis. A total of 108 articles were identified; 6 were selected for review. Based on the PICO (problem, intervention, comparison, outcome) model, the chief question of this study was: Can patients with alveolar ridge deficiency be successfully treated with the autogenous teeth used as bone graft?ResultsThe mean primary stability of the placed implants was 67.3 ISQ and the mean secondary stability was 75.5 ISQ. The dehiscence of the wound was the most frequent complication with a rate of 29.1%. Of the 182 analyzed implants, the survival rate was 97.7% and the failure rate was 2.3%. In the histological analysis, most of studies reported bone formation.ConclusionsThere is insufficient evidence regarding the effects of autogenous teeth used for bone grafting to support any definitive conclusions, although it has been shown clinically safe and good bone forming capacity, and good results are shown about implant stability. Key words:Bone regeneration, bone graft material, autogenous teeth graft, tooth.

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Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics

Cited by 28 publications

References 22 publications

Histomorphometric Evaluation of the Healing Process of Bony Defects Filled with Milled Teeth Versus Beta Tri-Calcium Phosphate Bone Graft Materials in Rats.

Histomorphometric Evaluation of the Healing Process of Bony Defects Filled with Milled Teeth Versus Beta Tri-Calcium Phosphate Bone Graft Materials in Rats.

Nano-Structured Demineralized Human Dentin Matrix to Enhance Bone and Dental Repair and Regeneration

Autogenous teeth used for bone grafting: A systematic review

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