Dementia in a punch-drunk wife

Roberts, Gareth W.; Whitwell, Helen; Acland, Peter R.; Bruton, C. J.

doi:10.1016/0140-6736(90)90520-f

Cited by 107 publications

(49 citation statements)

References 8 publications

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“…Roberts and colleagues also identified what appeared to be neuropathology characteristic of dementia pugilistica in a woman who had reportedly been repeatedly battered (Roberts et al, 1990b). She also had significant cerebrovascular disease.…”

Section: Pellucidum)mentioning

confidence: 91%

A critical review of chronic traumatic encephalopathy

Iverson

Gardner

McCrory

et al. 2015

Neuroscience & Biobehavioral Reviews

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Section: Pellucidum)mentioning

confidence: 91%

A critical review of chronic traumatic encephalopathy

Iverson

Gardner

McCrory

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…91 Case reports and series started to appear several decades later, during the 1950s and 1960s, describing pathological features associated with this condition such as cerebral atrophy, neuronal loss, gliosis, and argyrophilic neurofibrillary tangles. 18,27,81,102,123 Over time, investigators began to realize that the neurocognitive deficits seen in dementia pugilistica also affected men and women subjected to a broad range of brain trauma including physical abuse, head banging, poorly controlled epilepsy, and rugby. As discussed by McKee et al, 86 the term "chronic traumatic encephalopathy" was first introduced by Critchley in 1949 to more generally describe this condition as a collection of clinical symptoms.…”

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confidence: 99%

Sports-related brain injuries: connecting pathology to diagnosis

Pan¹,

Connolly²,

Dangelmajer³

et al. 2016

FOC

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Neurosurg Focus 40 (4):E14, 2016M any sports-related brain injuries involve mild traumatic brain injuries (mTBIs), which result from physical blows to the head sustained over a period of time. Sports associated with an increased risk of head injury include American football, ice hockey, soccer, rugby, the martial arts, boxing, and bicycling. 21,90 These injuries are often unrecognized, undiagnosed, or underreported, which reflects the fact that this is a growing medical concern, often labeled a "silent epidemic." 8,66 Chronic exposure to mild brain injuries can result in long-term neurological consequences and represents a spectrum of disorders. The most remarkable outcome of mTBI is termed chronic traumatic encephalopathy (CTE), a clinical syndrome that is associated with neurodegeneration and behavioral, cognitive, and/or motor deficits. Although this disease has distinct pathological features, CTE is considered a diagnosis of exclusion because only postmortem biopsies can confirm the diagnosis. Therefore, new diagnostic methods need to be developed to: 1) inform patients of a definitive diagnosis, 2) better understand the epidemiology and risk factors of the disease, and 3) implement intervention programs to prevent any potential long-term complications. This review examines how understanding the pathology and molecular changes associated with repeated head trauma can lead to the discovery of novel imaging techniques and biomarkers. Mild Traumatic Brain Injury and CTEChronic traumatic encephalopathy has evolved from the so-called punch-drunk syndrome, which was used to describe a distinct neuropsychiatric condition that seemed to affect boxers, eventually becoming known as dementia pugilistica during the 1920s and 1930s. Symptoms such ABBrEvIATIoNs AD = Alzheimer's disease; APOE = apolipoprotein E; ASL = arterial spin labeling; BBB = blood-brain barrier; BOLD = blood oxygen level-dependent; CA = cornu ammonis; CTE = chronic traumatic encephalopathy; DTI = diffusion tensor imaging; FA = fractional anisotropy; fMRI = functional MRI; GFAP = glial fibrillary acidic protein; GRE = gradient recall echo; miRNA = microRNA; MRS = MR spectroscopy; mTBI = mild traumatic brain injury; NFL = National Football League; NFT = neurofibrillary tangle; NINDS = National Institute of Neurological Disorders and Stroke; NSE = neuron-specific enolase; p-tau = phosphorylated tau; SWI = susceptibility-weighted imaging; TDP-43 = TAR DNA-binding protein 43;18 F-FDDNP = 2-(1-{6- [(2-[fluorine-18] Brain injuries are becoming increasingly common in athletes and represent an important diagnostic challenge. Early detection and management of brain injuries in sports are of utmost importance in preventing chronic neurological and psychiatric decline. These types of injuries incurred during sports are referred to as mild traumatic brain injuries, which represent a heterogeneous spectrum of disease. The most dramatic manifestation of chronic mild traumatic brain injuries is termed chronic traumatic encephalopathy, which is associated with profo...

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“…Evidence of CTE was found in non-athletes with a history of RBT, including individuals who exhibited self-injurious and/or head-banging behaviour, a victim of domestic abuse, a circus clown who sustained significant RBT on the job and an epileptic who sustained head injuries during seizure episodes [5,6,22,23]. Additionally, athletes outside of boxing were also shown to have the disease at autopsy.…”

Section: Introductionmentioning

confidence: 92%