A critical review of chronic traumatic encephalopathy

Iverson, Grant L.; Gardner, Andrew J.; McCrory, Paul; Zafonte, Ross; Castellani, Rudy J.

doi:10.1016/j.neubiorev.2015.05.008

Cited by 99 publications

(69 citation statements)

References 209 publications

(241 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CSF results report normal value of CSF Aβ 1-42 protein, confirming the possibility that the cognitive decline associated with TBI could be triggered by a pathogenic mechanism different from the amyloidogenic cascade [8].…”

Section: Discussionsupporting

confidence: 57%

“…CSF T-tau and Aβ 1-42 were shown to optimally discriminate AD from other dementias in an autopsy-confirmed study [14]. On the contrary, amyloid beta deposition is not a pathologic feature of CTE [4], with the possibility to have normal beta amolyid value even in cases with severe cognitive decline (as in the case described here) [8]. Recent neuropathological studies of TBI cases have described amyloid plaques acutely after a single severe TBI and tau pathology after repeat TBI.…”

Section: Discussionmentioning

confidence: 50%

“…CTE is the long term consequence of repeated TBIs, also of mild intensity, as frequent in contact sports as boxe, hockey, martial arts and American Football [7]. It is a chronic neurodegeneration that follows recurrent TBIs and it is characterised by cognitive and psycho behavioural symptoms that appear after a long or very long latency, in the large part of cases years after the traumatic events, with an observed latency that ranges from few weeks to some decades [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer's Disease

Grande¹,

Galimberti²,

Maggiore³

et al. 2017

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer's Disease

Grande¹,

Galimberti²,

Maggiore³

et al. 2017

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

“…6,43,54 While some reports support a causal link between neurocognitive decline and RBT, 64,65 others have suggested that the evidence is incomplete and that a direct causal link cannot be made at the present time. 11,26,27,62 Neuroimaging and neuropsychological testing represent evolving and commonly used modalities to quantify intracranial neurologic injury.…”

mentioning

confidence: 99%

184 Interrelationships Among Neuroimaging Biomarkers, Neuropsychological Test Data, and Symptom Reporting in a Cohort of Retired National Football League Players

Kuhn¹,

Zuckerman²,

Solomon³

et al. 2016

Neurosurgery

View full text Add to dashboard Cite

show abstract

“…For a comprehensive review of this literature see Manley et al [104], Iverson et al [111], Gardner et al [112], Randolph et al [113], and McCrory et al [114].…”

Section: Potential Longer Term Concernsmentioning

confidence: 99%

Sports Concussion: A Clinical Overview

Gardner¹

2018

Sport and Exercise Science

Self Cite

View full text Add to dashboard Cite

Concussion is an injury risk associated with participation in collision sports. It has been identified as a research priority for many contacts and collision sports governing bodies worldwide. However, concussion remains under-researched in terms of clinical translation from both experimental models to clinical understanding, and from clinical studies to sports policy. Currently, the clinical management of concussion is largely guided by the presence or absence of symptoms with recovery indicated once all post-injury symptoms have resolved. Management of concussion includes physical and cognitive rest until acute symptoms resolve, with a graded program of exertion implemented prior to medical clearance and return-to-play. Considering the potential sequelae, the heterogeneity of symptoms, and the lack of an intervention known to prevent concussion, it is not any wonder that concussion is one of the most complex and perplexing injuries faced by medical professionals, and why making the return-to-play decision can be quite challenging. This chapter will provide an overview of the current clinical management guidelines and research literature pertaining to identification and diagnosis of injury, acute and post-acute management, and return-to-play decision-making. The traditional standard assessment process (e.g., symptom reporting, cognitive assessment, balance testing), new methods and advanced technology (e.g., ocular-motor testing, neuroimaging techniques), and biomarkers (e.g., blood plasma and serum, fluid) have led to greater insights into sports concussion and will also be briefly explored in this chapter.

show abstract

A critical review of chronic traumatic encephalopathy

Cited by 99 publications

References 209 publications

Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer's Disease

Recurrent Head Trauma: A Trigger of the Alzheimer Cascade or the Cause of an Independent Pathologic Entity? - An Explicative Case of Chronic Traumatic Encephalopathy Mimicking Alzheimer's Disease

184 Interrelationships Among Neuroimaging Biomarkers, Neuropsychological Test Data, and Symptom Reporting in a Cohort of Retired National Football League Players

Sports Concussion: A Clinical Overview

Contact Info

Product

Resources

About