184 Interrelationships Among Neuroimaging Biomarkers, Neuropsychological Test Data, and Symptom Reporting in a Cohort of Retired National Football League Players

Kuhn, Andrew W; Zuckerman, Scott L.; Solomon, Gary S.; Casson, Ira R.

doi:10.1227/01.neu.0000489753.67038.ae

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…The presence of a CSP was also more common in a group of retired NFL players with cognitive and mental health symptoms (94%) than matched controls (18%) (59), and the length of the CSP in retired NFL players was significantly longer as well. Similar to these findings, another sample of 45 retired NFL players found that 7% had a CSP, 71% had a small one, and 22% did not have one (74).…”

Section: Cavum Septum Pellucidum (Csp)supporting

confidence: 63%

“…The majority of the neuroimaging studies included in this review were conducted with retired professional athletes. Of these, the majority of the samples were comprised of retired NFL or CFL players (32,33,36,44,45,50,51,53,55,56,58,59,72,74,75). The other studies included professional fighters (34,65,67,68) or athletes from other contact sports (48,49,52,62,66,(69)(70)(71)73).…”

Section: Athletesmentioning

confidence: 99%

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Systematic Review of the Long-Term Neuroimaging Correlates of Mild Traumatic Brain Injury and Repetitive Head Injuries

2021

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Objective: To systematically review the literature on the long-term neuroimaging findings (≥10 years from exposure) for exposure in adulthood to mild traumatic brain injury (mTBI) and repetitive head impacts (RHIs) using neuroimaging across all available populations.Data sources: Four electronic databases: MEDLINE, SPORTDiscus, PsycINFO, and EMBASE.Study selection: All articles were original research and published in English. Studies examined adults with remote exposure to mTBI and/or RHIs from ten or more years ago in addition to any associated neuroimaging findings.Data extraction: Parameters mainly included participants' population, age, years since head injury, race, sex, education level, and any neuroimaging findings. Scores for the level of evidence and risk of bias were calculated independently by two authors.Results: 5,521 studies were reviewed, of which 34 met inclusion criteria and were included in this study. The majority of adults in these studies showed positive neuroimaging findings one or more decades following mTBI/RHI exposure. This was consistent across study populations (i.e., veterans, athletes, and the general population). There was evidence for altered protein deposition patterns, micro- and macro-structural, functional, neurochemical, and blood flow-related differences in the brain for those with remote mTBI/RHI exposure.Conclusion: Findings from these studies suggest that past mTBI/RHI exposure may be associated with neuroimaging findings. However, given the methodological constraints related to relatively small sample sizes and the heterogeneity in injury types/exposure and imaging techniques used, conclusions drawn from this review are limited. Well-designed longitudinal studies with multimodal imaging and in-depth health and demographic information will be required to better understand the potential for having positive neuroimaging findings following remote mTBI/RHI.

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Section: Cavum Septum Pellucidum (Csp)supporting

confidence: 63%

Section: Athletesmentioning

confidence: 99%

Systematic Review of the Long-Term Neuroimaging Correlates of Mild Traumatic Brain Injury and Repetitive Head Injuries

2021

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“…A CSP can be observed on conventional MRI. Former NFL players exhibit greater rates of CSP (Gardner, Hess, et al, 2016;Gardner, Possin, et al, 2015;Koerte et al, 2016;Kuhn, Zuckerman, Solomon, & Casson, 2016), greater CSP length, and greater ratio of CSP length to septum length (Koerte et al, 2016). Greater CSP length has been identified as a correlate of poorer verbal learning and word reading in former NFL players (Koerte et al, 2016).…”

Section: Cavum Septum Pellucidummentioning

confidence: 99%

Chronic traumatic encephalopathy and the long-term consequences of repetitive head impacts in sports.

Alosco¹,

Healy²,

Stern³

2019

Neuropsychology of Sports-Related Concussion.

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This chapter focuses on the long-term consequences of sports-related repetitive head impacts (RHI), including impacts resulting in symptomatic concussions as well as subconcussive trauma. In concussion, there is a transfer of mechanical energy to the brain from a direct or indirect force to the head that results in neuronal injury and a wide range of associated symptoms and signs (Giza & Hovda, 2014;McCrory et al., 2017). In contrast, subconcussive head trauma is believed to involve similar, though of lesser magnitude, mechanical forces and neuronal injury, but not to result in the immediate symptoms and signs of concussion (Broglio, Eckner, Paulson, & Kutcher, 2012). Subconcussive head trauma often occurs in the setting of contact sports, particularly American football. Helmet accelerometer studies have shown that high school football players can average 600 subconcussive impacts per season, and this can increase to over 1,000 at the collegiate level (

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Structural neuroimaging in sport-related concussion

Bigler

2018

International Journal of Psychophysiology

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184 Interrelationships Among Neuroimaging Biomarkers, Neuropsychological Test Data, and Symptom Reporting in a Cohort of Retired National Football League Players

Abstract: Background: Structural brain changes, potentially resulting from repetitive brain trauma (RBT), have been correlated with neurocognitive decline and increased symptom reporting in retired athletes.

Cited by 5 publications

References 38 publications

Systematic Review of the Long-Term Neuroimaging Correlates of Mild Traumatic Brain Injury and Repetitive Head Injuries

Systematic Review of the Long-Term Neuroimaging Correlates of Mild Traumatic Brain Injury and Repetitive Head Injuries

Chronic traumatic encephalopathy and the long-term consequences of repetitive head impacts in sports.

Structural neuroimaging in sport-related concussion

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