Dementia and survival in Parkinson disease

Buter, Tirza C. E.; Hout, Ardo van den; Matthews, Fiona E.; Larsen, Jan Petter; Brayne, Carol; Aarsland, Dag

doi:10.1212/01.wnl.0000306632.43729.24

Cited by 412 publications

(263 citation statements)

References 36 publications

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“…Its incidence increases with age, 11 and its burden will double over the next generation. 12 Individuals have Parkinson's disease for approximately 14-16 years after diagnosis, 13,14 and it leads to progressive disability, cognitive impairment, limited mobility, 15 and impaired driving ability. 16 Parkinson's disease also burdens caregivers, 17 frequently requires institutional care, [18][19][20] generates high healthcare costs, 21,22 and benefits from specialty care.…”

Section: -10mentioning

confidence: 99%

National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers

Dorsey

Achey

Beck

et al. 2016

Telemedicine and e-Health

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Section: -10mentioning

confidence: 99%

National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers

Dorsey

Achey

Beck

et al. 2016

Telemedicine and e-Health

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“…Dementia develops in up to 60% of patients suffering from Parkinson's disease (PD) (Buter et al 2008), and importantly contributes to the impairment of the quality of life and to caregiver distress. The mechanisms of PD related dementia (PDD) are still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

MEG resting state functional connectivity in Parkinson’s disease related dementia

et al. 2008

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Parkinson's disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer's disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD.

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“…One study reported that the cumulative incidence of developing cognitive impairment was 8.5% within 1-year follow-up, and up to 47.4% within 6-year follow-up [24]. In another study, the incidence of cognitive impairment in PD patients increased to 60% by 12 years of retrospective follow-up [25]. However, cognitive decline was found to be stable in newly diagnosed patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function in Early and Advanced Parkinson’s disease

Chen¹,

Wang²

2018

Neuropsychiatry

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Objective: To investigate the occurrence of mild cognitive impairment (MCI) in early and advanced Parkinson's disease (PD) and identify the risk factors for PD-MCI.Methods: A total of 138 PD patients were recruited between April 2015 and December 2017. We evaluated demographic and clinical data, including sex, age, age of onset, disease duration, Hoehn and Yahr stage, Unified Parkinson's Disease Rating Scale (UPDRS) part Ⅲ, 39-item Parkinson's Disease Questionnaire (PDQ-39), Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI) and Mini-Mental State Examination (MMSE) scores. Participants were divided into early and advanced PD groups according to Hoehn and Yahr stage. Group comparisons were performed using Student's t-tests or chi-square tests. Binary logistic regression was conducted to identify risk factors for PD-MCI. Results:There was no significant difference in MMSE scores between the early and advanced groups. According to PD-MCI Level 1 criteria, 27 individuals (30.0%) in the early group and 16 individuals (33.3%) in the advanced group were classified as having PD-MCI. The proportion of PD-MCI was not significantly different between the two groups (chi-square = 0.162, p = 0.687). No demographic or clinical factors were significantly associated with the development of PD-MCI. Conclusions:Cognitive impairment is stable in PD patients with short disease duration when the MMSE is used as a global cognitive test. The occurrence of PD-MCI is high, even in newly diagnosed PD patients.

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Dementia and survival in Parkinson disease

Abstract: Dementia is a key part of survival in Parkinson disease and must be planned for in services for this condition.

Cited by 412 publications

References 36 publications

National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers

National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers

MEG resting state functional connectivity in Parkinson’s disease related dementia

Cognitive Function in Early and Advanced Parkinson’s disease

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