Deltamethrin-resistant German Cockroaches Are Less Sensitive to the Insect Repellents DEET and IR3535 than Non-resistant Individuals

Mengoni, Sofía L.; Alzogaray, Raúl A.

doi:10.1093/jee/toy009

Cited by 14 publications

(5 citation statements)

References 20 publications

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“…Our results provide evidence that broad cross-resistance to insect repellents is present in the pyrethroid-resistant PR mosquitoes. The present results with DEET and IR3535 corroborate those obtained by Mengoni and Algogaray in which pyrethroid-resistant German cockroaches showed less sensitivity to these repellent standards, 23 as well as the report of DEET resistance in a strain of pyrethroid-resistant bed bug (Hemiptera: Cimicidae). 30 Our study also observed significant resistance to both the toxicity and repellency of pyrethrum, transfluthrin, and metofluthrin in the PR strain, similar to that observed for transfluthrin in a selected pyrethroid-resistant strain of Ae.…”

Section: Discussionsupporting

confidence: 92%

“…In related studies, Mengoni and Alzogaray claimed that two deltamethrin‐resistant strains of German cockroach, Blattella germanica (L.) (Blattodea: Blattellidae), had decreased sensitivity to N , N ‐diethyl‐3‐methylbenzamide (DEET) and ethyl 3‐[acetyl(butyl)amino] propanoate (IR3535) . According to their statistical analysis, both strains had reduced responses to IR3535, while only one strain showed about 2‐fold resistance to DEET, even though both strains were highly resistant to deltamethrin (RR > 677).…”

Section: Introductionmentioning

confidence: 99%

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Reduced effectiveness of repellents in a pyrethroid‐resistant strain of Aedes aegypti (Diptera: culicidae) and its correlation with olfactory sensitivity

Liu

Norris

Jiang

et al. 2019

Pest Management Science

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BACKGROUND The mosquito, Aedes aegypti (Diptera: Culicidae), is a vector of dengue fever, zika, chikungunya, and yellow fever viruses, and in many areas possesses significant levels of resistance to pyrethroids. Behavioral performance was assessed in 15, 30, and 60 min exposures in a high throughput vapor phase spatial repellency assay to three contact repellent standards: N,N‐diethyl‐3‐methylbenzamide (DEET), ethyl 3‐[acetyl(butyl)amino] propanoate (IR3535), and 2‐undecanone, as well as pyrethrum extract, transfluthrin, and metofluthrin in susceptible (Orlando) and a pyrethroid‐resistant Puerto Rico strain of Aedes aegypti. Additionally, electroantennographic studies were used to investigate the antennal sensitivities to these compounds in both strains. RESULTS Resistance was found to all tested insect repellents in the Puerto Rico strain of Ae. aegypti. Resistance ratios at the different time points were about 2 for DEET, 3 for 2‐undecanone, and 12 for IR3535. Resistance was also observed to pyrethrum extract (∼9‐fold), transfluthrin (∼5‐fold), and metofluthrin (∼48‐fold) in repellent behavioral response. Electrophysiological analysis found decreased antennal sensitivity to all repellents tested, consistent with their behavioral effects. CONCLUSION The reduced sensitivity to these repellents may represent a fitness cost arising from the kdr mutation present in Puerto Rico Aedes aegypti. This work highlights the need for understanding collateral effects from the evolution of pesticide resistance in mosquitoes, and the importance of finding alternative strategies to control resistance development. © 2019 Society of Chemical Industry

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Reduced effectiveness of repellents in a pyrethroid‐resistant strain of Aedes aegypti (Diptera: culicidae) and its correlation with olfactory sensitivity

Liu

Norris

Jiang

et al. 2019

Pest Management Science

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“…The resistance rate in the RMKN-BKT and KRSA-BDG was more than 80 and 73 times, respectively. In B. germanica, deltamethrin-resistant cases have been reported previously in several countries such as Malaysia 16 , Singapore 17 , America 12 , Nigeria 18 , South Korea 19 and Argentina 20 . The widespread of deltamethrin-resistant arises presumably due to insecticides' overuse and/or misuse.…”

Section: Discussionmentioning

confidence: 93%

Detection of Voltage-Gated Sodium Channel (VGSC) Mutation in Deltamethrin-Resistant Blattella germanica L. from Indonesia

Rahayu¹,

Hasmiwati²,

Saputra³

2022

Pakistan J. of Biological Sciences

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Background and Objective: German cockroach (Blattella germanica L.) is one of the most common residential pests in Indonesia.Controlling the population face obstacles due to insecticide resistance, especially to deltamethrin. This research investigated the resistance status and the possibility of a Voltage-Gated Sodium Channel (VGSC) knockdown resistance mutation (L1014F) in two field strains of German cockroaches collected from two cities in Indonesia (Bukittinggi, named RMKN-BKT and Bandung, named KRSA-BDG) with VCRU-WHO as the standard strain. Materials and Methods: This study started with a bioassay test to determine the lethal dose of 50% (LD 50 ) for each strain and followed by a molecular test for mutation detection. Results: The results showed that the RMKN-BKT and KRSA-BDG strains were highly resistant to deltamethrin with RR50 values of 80,090 times and 73,272 times, respectively. Only the RMKN-BKT strain was shown to carry L1014F kdr mutation which lead to an amino acid replacement from leucine (TTG) to phenylalanine (TTC). Two silent mutations were also found in both field strains at codons 983 (TGC/cysteine÷TGT/cysteine) and 984 (GGG/ glycine÷GGA/glycine) which were suggested as polymorphism phenomena. The absence of the L1014F mutation in the Bandung strain does not exclude the possibility of the presence of the VGSC mutation at other points. Conclusion: It requires subsequent investigation in mutation detection at other points and the possible presence of other resistance mechanisms to get a precise solution in the population control. Bioinsecticides may stand as a breakthrough so that the strategy will no longer focus on insecticides.

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“…Insects with resistant genotypes pay an energetic cost that reduces their fitness compared to susceptible conspecifics. Hemiptera, Diptera, Coleoptera, and Lepidoptera have all been observed with this trait ( Kliot and Ghanim, 2012 ; Mengoni and Alzogaray, 2018 ; Castellanos et al, 2019 ). Compared to other resistant strains of German cockroach, certain pyrethrin- and allethrin-resistant cockroaches have an irregular pattern of development among the nymphs and a lower total fecundity ( Zhang and Yang, 2019 ).…”

Section: Blattodeamentioning

confidence: 99%

Fitness costs of resistance to insecticides in insects

Gul,

Gadratagi,

Güncan

et al. 2023

Front. Physiol.

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The chemical application is considered one of the most crucial methods for controlling insect pests, especially in intensive farming practices. Owing to the chemical application, insect pests are exposed to toxic chemical insecticides along with other stress factors in the environment. Insects require energy and resources for survival and adaptation to cope with these conditions. Also, insects use behavioral, physiological, and genetic mechanisms to combat stressors, like new environments, which may include chemicals insecticides. Sometimes, the continuous selection pressure of insecticides is metabolically costly, which leads to resistance development through constitutive upregulation of detoxification genes and/or target-site mutations. These actions are costly and can potentially affect the biological traits, including development and reproduction parameters and other key variables that ultimately affect the overall fitness of insects. This review synthesizes published in-depth information on fitness costs induced by insecticide resistance in insect pests in the past decade. It thereby highlights the insecticides resistant to insect populations that might help design integrated pest management (IPM) programs for controlling the spread of resistant populations.

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Deltamethrin-resistant German Cockroaches Are Less Sensitive to the Insect Repellents DEET and IR3535 than Non-resistant Individuals

Cited by 14 publications

References 20 publications

Reduced effectiveness of repellents in a pyrethroid‐resistant strain of Aedes aegypti (Diptera: culicidae) and its correlation with olfactory sensitivity

Reduced effectiveness of repellents in a pyrethroid‐resistant strain of Aedes aegypti (Diptera: culicidae) and its correlation with olfactory sensitivity

Detection of Voltage-Gated Sodium Channel (VGSC) Mutation in Deltamethrin-Resistant Blattella germanica L. from Indonesia

Fitness costs of resistance to insecticides in insects

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