“…Neogenin, a Type I transmembrane protein of the DCC (deleted in colorectal cancer) family, was identified as a receptor for the axon guidance cue netrin-1 as well as repulsive guidance molecules (Vielmetter et al, 1994;Rajagopalan et al, 2004;De Vries and Cooper, 2008;Xu et al, 2014). Recent data suggest that Neogenin has diverse functions in various organs, such as endochondral bone formation , neural tube formation (Kee et al, 2008), digit patterning (Hong et al, 2012), ion metabolism (Kuns-Hashimoto et al, 2008;Lee et al, 2010), and muscle differentiation (Kang et al, 2004). Neogenin is expressed in embryonic and adult neural stem cells (Fitzgerald et al, 2007;van den Heuvel et al, 2013) and has been implicated in adult neurogenesis (O'Leary et al, 2015;.…”