Abstract:GABAA receptors containing the GABAA subunit (GABAARs) are involved in many physiological and pathophysiological processes, such as sleep, pain, stress, anxiety-related behaviors, and postpartum depression. These extrasynaptically located, high affinity and slowly desensitizing receptors mediate tonic inhibition throughout the brain, including in granule cells (GCs) of the cerebellar input layer. However, the extent to which GABAARs control the excitability of the cerebellar input layer and ultimately regul… Show more
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