Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood

Aldhafiri, Ahmed; Dodu, Julien C.; Alalawi, Ali; Emadzadeh, Nariman; Soderstrom, Ken

doi:10.1016/j.pbb.2019.172764

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Patients less than 18 years old were not included from the study. Data included sex, age, previous comorbidities, vital signs and laboratory results on admission including respiration rate (RR), heart rate (HR), mean arterial blood pressure (BP), oxygen saturation (SpO2), complete blood count (CBC), C‐reactive protein (CRP), serum ferritin, alanine transaminase (ALT), aspartate transaminase (AST), serum creatinine, serum albumin, total bilirubin, direct bilirubin, lactate dehydrogenase, 13 creatine kinase (CK), D‐Dimer, international normalized ratio (INR) and activate partial thromboplastin time (aPTT). The modality of ventilation and the survival/death outcomes were also collected.…”

Section: Methodsmentioning

confidence: 99%

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Aljohani¹,

Khattab²,

Elbadawy

et al. 2022

Clinical Laboratory Analysis

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Background: Coronavirus disease 2019, COVID-19, has reached all the corners of the world and was declared by the WHO as a global pandemic and public health emergency of international concern on the January 31, 2020. Allocating quick and specific biomarkers to predict the disease severity upon admission to hospital became a crucial need. This study, therefore, aimed at exploring the relationship between laboratory results in COVID-19 patients admitted to hospital and the final outcome in these patients. Methods: Retrospective analysis was performed on the medical records of 310 COVID-19-positive patients admitted to Uhod Hospital, the referral hospital in the area of Madinah, Kingdom of Saudi Arabia, between the April 13 and the July 29, 2020. The association of laboratory results with the survival/mortality outcomes was studied. Results: It was demonstrated that lymphopenia, prolonged aPTT, high INR, high D. dimer and high CK are valuable prognostic predictors of the severity of the disease at early stages that can determine the outcome. Based on the results of the multiple logistic regression, the variables that are associated with death outcome are aPTT, HR, RR, ALT and CK level Conclusion: It is proposed to perform these tests on admission to hospital for moderate to severe COVID-19 patients to improve the management of those cases and reduce mortality.

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Section: Methodsmentioning

confidence: 99%

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Aljohani¹,

Khattab²,

Elbadawy

et al. 2022

Clinical Laboratory Analysis

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“…In another sphere of cardiovascular-based biomedical research, the vessels of the chicken embryo's choriallanotic membrane (CAM) have been used as a model vascular bed for angiogenesis (Ricklefs, 1985 ; Schew et al, 1996 ; McNabb, 2007 ; Wada, 2008 ; Bateson and Feenders, 2010 ; Margoliash, 2010 ; Ottinger et al, 2013 ; Nowak-Sliwinska et al, 2014 ; Olson et al, 2014 ; Bolhuis and Moorman, 2015 ; Aldhafiri et al, 2019 ; Bertram et al, 2020 ). The CAM is a highly specialized vascular bed for gas exchange generally viewed as homologous to the fetoplacental vessels of mammals.…”

Section: Pros and Cons Of The Chicken As An Avian Experimental Modelmentioning

confidence: 99%

“…A key model in this regard in the zebra finch, which has been used to further understand the neurobiology of learning ( Figure 6 ) (Heston and White, 2017 ; Gobes et al, 2019 ; London, 2020 ). The zebra finch has also been used to determine how substances commonly abused by humans alter learned song (Lovell et al, 2011 ; Olson et al, 2014 ; Aldhafiri et al, 2019 ), and cognition (Clayton and Emery, 2015 ; Fishbein et al, 2020 ). Such experiments have not only focused on their whole animal behavior, but also moved into assessment of the genomics, transcriptomics, and proteomics of learning (Lovell et al, 2011 ; Clayton, 2013 ; Mello and Clayton, 2015 ; London, 2020 ).…”

Section: Alternative Avian Models For Research In Developmentmentioning

confidence: 99%

Beyond the Chicken: Alternative Avian Models for Developmental Physiological Research

Flores-Santin

Burggren

2021

Front. Physiol.

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Biomedical research focusing on physiological, morphological, behavioral, and other aspects of development has long depended upon the chicken (Gallus gallus domesticus) as a key animal model that is presumed to be typical of birds and generally applicable to mammals. Yet, the modern chicken in its many forms is the result of artificial selection more intense than almost any other domesticated animal. A consequence of great variation in genotype and phenotype is that some breeds have inherent aberrant physiological and morphological traits that may show up relatively early in development (e.g., hypertension, hyperglycemia, and limb defects in the broiler chickens). While such traits can be useful as models of specific diseases, this high degree of specialization can color general experimental results and affect their translational value. Against this background, in this review we first consider the characteristics that make an animal model attractive for developmental research (e.g., accessibility, ease of rearing, size, fecundity, development rates, genetic variation, etc.). We then explore opportunities presented by the embryo to adult continuum of alternative bird models, including quail, ratites, songbirds, birds of prey, and corvids. We conclude by indicating that expanding developmental studies beyond the chicken model to include additional avian groups will both validate the chicken model as well as potentially identify even more suitable avian models for answering questions applicable to both basic biology and the human condition.

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Cocaine-induced Fos expression in the rat brain: Modulation by prior Δ9-tetrahydrocannabinol exposure during adolescence and sex-specific effects

et al. 2021

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Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood

Cited by 5 publications

References 34 publications

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Beyond the Chicken: Alternative Avian Models for Developmental Physiological Research

Cocaine-induced Fos expression in the rat brain: Modulation by prior Δ9-tetrahydrocannabinol exposure during adolescence and sex-specific effects

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