DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis

Li, Kunlun; Yu, Renbo; Fan, Liu‐Min; Wei, Ning; Chen, Haodong; Deng, Xing Wang

doi:10.1038/ncomms11868

Cited by 189 publications

(192 citation statements)

References 59 publications

(110 reference statements)

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“…Several independent studies demonstrated that the DELLA proteins physically interact with PIFs and sequester them into an inactive complex to restrain PIFs from binding to their targets (de Lucas et al, 2008; Feng et al, 2008; Gallego-Bartolomé et al, 2010). Recently it has been also shown that DELLAs not only sequester PIFs but also induce their degradation (Figure 3A), and more importantly, DELLAs-mediated degradation of PIFs functions independently of well-established phyB/LRBs pathways (Li et al, 2016). Thus, crosstalks between light and GA signaling pathways play an important role in fine-tuning germination and photomorphogenesis for optimal growth and development of plants.…”

Section: Pifs Integrate Light and Hormone Signaling Pathwaysmentioning

confidence: 95%

Expanding Roles of PIFs in Signal Integration from Multiple Processes

et al. 2017

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PHYTOCHROME INTERACTING FACTORs (PIFs) are members of the basic helix-loop-helix (bHLH) family of transcription factors in Arabidopsis. Since their discovery in phytochrome-mediated light signaling pathways, recent studies have unraveled new functions of PIFs in integrating multiple signaling pathways not only by their role as transcription factors directly targeting gene expression, but also by interacting with diverse groups of factors to optimize plant growth and development. These include endogenous (e.g., hormonal) as well as abiotic (light, circadian and elevated temperature) and biotic (defense responses) pathways. PIFs interact with key factors in each of these pathways, and tailor the outcome of the signal integration among these pathways. This review summarizes the role of PIFs as pivotal signal integrators in regulating plant growth and development.

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Section: Pifs Integrate Light and Hormone Signaling Pathwaysmentioning

confidence: 95%

Expanding Roles of PIFs in Signal Integration from Multiple Processes

et al. 2017

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“…Strikingly, a recent study showed that DELLA proteins not only sequester PIFs but also induce their degradation to regulate target gene expression (Li et al, 2016). Thus, DELLA proteins and phytochromes regulate PIFs in a similar fashion.…”

Section: Factors Inhibiting the Dna-binding Ability Of Pifsmentioning

confidence: 99%

“…In a recent study, DELLA proteins also were shown to promote the degradation of all four PIFs through the 26S proteasome pathway under both dark and light conditions (Li et al, 2016). Thus, DELLAs inhibit PIF activity not only by sequestration but also by PIF degradation to regulate hypocotyl elongation.…”

Section: Factors Controlling Pif Abundance Under Darknessmentioning

confidence: 99%

Phytochromes and Phytochrome Interacting Factors

2017

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The basic helix-loop-helix domain-containing transcription factors that interact physically with the red and far-red light photoreceptors, phytochromes, are called PHYTOCHROME INTERACTING FACTORS (PIFs). In the last two decades, the phytochrome-PIF signaling module has been shown to be conserved from Physcomitrella patens to higher plants. Exciting recent studies highlight the discovery of at least four distinct kinases (PPKs, CK2, BIN2, and phytochrome itself) and four families of ubiquitin ligases (SCF EBF 1/2 , CUL3 LRB , CUL3 BOP , and CUL4 COP1-SPA ) that regulate PIF abundance both in dark and light conditions. This review discusses these recent discoveries with a focus on the central phytochrome signaling mechanisms that have a profound impact on plant growth and development in response to light.

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“…Recently, PIF3 was shown to be phosphorylated directly by photoregulatory protein kinases (PPKs), and targeted by LRB Cullin 3 E3 ligases together with phyB for ubiquitination and degradation (21,22). DELLAs promote the degradation of PIF3 and PIF4 in a light-independent manner by recruiting an unknown E3 ligase (23). BIN2, a protein kinase involved in BR signaling, has also been shown to mediate phosphorylation and degradation of PIF3 via the 26S proteasome pathway (24).…”

mentioning

confidence: 99%

PIF3 is a negative regulator of theCBFpathway and freezing tolerance inArabidopsis

Jiang

Shi

Zhang

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

221

152

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Light and temperature are major environmental factors that coordinately control plant growth and survival. However, how plants integrate light and temperature signals to better adapt to environmental stresses is poorly understood. PHYTOCHROME-INTERACTING FACTOR 3 (PIF3), a key transcription factor repressing photomorphogenesis, has been shown to play a pivotal role in mediating plants' responses to various environmental signals. In this study, we found that PIF3 functions as a negative regulator of Arabidopsis freezing tolerance by directly binding to the promoters of C-REPEAT BINDING FACTOR (CBF) genes to down-regulate their expression. In addition, two F-box proteins, EIN3-BINDING F-BOX 1 (EBF1) and EBF2, directly target PIF3 for 26S proteasome-mediated degradation. Consistently, ebf1 and ebf2 mutants were more sensitive to freezing than were the wild type, and the pif3 mutation suppressed the freezingsensitive phenotype of ebf1. Furthermore, cold treatment promoted the degradation of EBF1 and EBF2, leading to increased stability of the PIF3 protein and reduced expression of the CBF genes. Together, our study uncovers an important role of PIF3 in Arabidopsis freezing tolerance by negatively regulating the expression of genes in the CBF pathway.freezing tolerance | CBFs | PIF3 | EBF1 | EBF2

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DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis

Cited by 189 publications

References 59 publications

Expanding Roles of PIFs in Signal Integration from Multiple Processes

Expanding Roles of PIFs in Signal Integration from Multiple Processes

Phytochromes and Phytochrome Interacting Factors

PIF3 is a negative regulator of theCBFpathway and freezing tolerance inArabidopsis

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