Delivery outcome after the use of antidepressants in early pregnancy

Ericson, Anders; Källén, Bëngt; Wiholm, Bengt‐Erik

doi:10.1007/s002280050664

Cited by 246 publications

(140 citation statements)

References 9 publications

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“…The risk of congenital malformations, large for gestational age, and respiratory problems was higher after exposure to TCAs than after exposure to SSRIs or other antidepressants. 8,25,26 It is possible that TCAs may have different pharmacokinetic properties than SSRIs and thereby have an effect on asthma. Uncontrolled confounding is another possible explanation.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Use During Pregnancy and Asthma in the Offspring

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Antidepressant Use During Pregnancy and Asthma in the Offspring

et al. 2015

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“…A number of studies have reported an increased risk for preterm birth with in utero exposure to antidepressants (9)(10)(11)(12)(13)(14). Our group recently found that prenatal antidepressant use, independent of depression, was associated with a lower gestational age and an increased risk of prematurity (15).…”

Section: Introductionmentioning

confidence: 99%

Saliva Estriol Levels in Women with and Without Prenatal Antidepressant Treatment

Suri¹,

Hellemann²,

Cohen³

et al. 2008

Biological Psychiatry

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Objective-Prenatal antidepressant use has been associated with shorter pregnancy duration and an increased risk for preterm birth. This study measured saliva levels of estriol, a hormone which increases exponentially in the few weeks before spontaneous labor, in pregnant women with and without antidepressant treatment.Method-Saliva estriol levels were obtained across the day at three time points during pregnancy in 77 subjects with either a history of DSM-IV major depressive disorder (MDD) who were treated with antidepressants in pregnancy (Group 1), a history of DSM-IV major depressive disorder who were not treated or had limited exposure to antidepressants during pregnancy (Group 2), and a normal control group (Group 3).Results-Mean estriol levels in the second half of pregnancy were significantly higher for Group 1 (h/o MDD, on meds) than Group 2 (h/o MDD, off meds) or Group 3 (control).Conclusions-Prenatal antidepressant use was associated with significantly higher saliva estriol levels in the second half of pregnancy. Whether estriol reflects a causal mechanism by which women on antidepressants have shorter pregnancy duration remains to be further studied.

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“…In a long-term study on mothers who took fluoxetine during pregnancy and on their total of 55 infants, no difference in the overall intelligence and language development of the infants and the control group, nor in their temperaments, moods, arousal states, activity levels, distractibility, and behavioral problems, was observed [17]. According to the Swedish National Registry data [18], the intake of paroxetine during the first gestational period increases the risk of the infant developing congenital heart abnormality, so it is not recommended for use during pregnancy. Sertraline has been reported as not having increased the risk of congenital abnormality, miscarriage, and still birth [18,19].…”

Section: Drug Treatment During Pregnancymentioning

confidence: 97%

“…According to the Swedish National Registry data [18], the intake of paroxetine during the first gestational period increases the risk of the infant developing congenital heart abnormality, so it is not recommended for use during pregnancy. Sertraline has been reported as not having increased the risk of congenital abnormality, miscarriage, and still birth [18,19]. Fluvoxamine and citalopram are Category C drugs.…”

Section: Drug Treatment During Pregnancymentioning

confidence: 99%