Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

“…8 Ishida et al have reported that although integration of polyethylene glycol (PEG) in the surface of nanoparticles lengthens the circulation time by allowing evasion of the macrophage system, their retention in vivo is still severely impaired. 9 As we previously reported, poly(N-vinylpyrrolidone) (PVP), a good alternative to PEG, 10,11 enhances the in vivo circulation time in that it evades the reticuloendothelial system more efficiently.…”

Nanoparticles to Deal with Gastric Cancer

“…Zhang et al prepared ursolic acid loaded nanoparticles, where mPEG-PCL (methoxy poly(ethylene glycol)-polycaprolactone) co-polymer work as a carrier system and tested it on gastric cancer cells. They found increased apoptosis of gastric cancer cells [23]. Another well-known anticancer agent cerium oxide nanoparticles also known as CNP has He and his colleagues then tested it on gastric cell lines.…”

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

“…A series of new heterocyclic derivatives of ursolic acid showed potent antiproliferative activity and induction of p53, p21waf1 and NOXA against pancreatic cancer cell lines AsPC-1 [71]. Interestingly, ursolic acid-loaded nanoparticles (UANPs) were recently prepared by Zhang et al [72] using a nanoprecipitation method employing amphilic methoxy poly (ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers as drug carriers. Ursolic acid was effectively transported into gastric cancer SGC7901 cells by nanoparticles and localized around the nuclei in the cytoplasm.…”