Nanoparticles to Deal with Gastric Cancer

Kuddus, Syed Abdul

doi:10.4172/2572-4126.1000112

Cited by 1 publication

(1 citation statement)

References 45 publications

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“…Complete prevention of gastric cancer is difficult to achieve. A multitude of factors are related to the disease, such as genetics, dietary habits, environmental elements and bacterial infection (4,5). The majority of patients with gastric cancer do not exhibit obvious symptoms until the cancer is advanced and cannot be treated effectively.…”

Section: Introductionmentioning

confidence: 99%

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Wang

et al. 2020

Front. Oncol.

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Postoperative recurrence is a common and severe problem in the treatment of gastric cancer; consequently, a prolonged course of chemotherapy treatment is inevitable. Monitoring by imaging could provide an accurate evaluation of the therapeutic effects, which would be beneficial to guide a treatment strategy adjustment over time. However, current imaging technologies remain insufficient for the continuous postoperative monitoring of gastric cancer. In this case, molecular imaging offers an efficient strategy. Targetable contrast agents are an essential part of molecular imaging, which could greatly enhance the accuracy and quality of monitoring. Herein, we synthesized a Mn-based contrast agent for magnetic resonance imaging (MRI) of gastric cancer monitoring. Initially, small-sized Mn 3 O 4 nanoparticles (NPs) were synthesized. Then, a functionalized polyethylene glycol (PEG) lipid was attached to the surface of the Mn 3 O 4 NPs, to improve biocompatibility. The targetable MRI contrast agent (Mn 3 O 4 @PEG-RGD NPs) was further prepared by the conjugation of the arginine-glycine-aspartic acid (RGD) peptides. The completed Mn 3 O 4 @PEG-RGD NPs had the small size of 7.3 ± 2.7 nm and exhibited superior colloidal stability in different solution environments. In addition, Mn 3 O 4 @PEG-RGD NPs exhibited reliable biotolerance and low toxicity both in vitro and in vivo. Imaging experiments amply demonstrated that Mn 3 O 4 @PEG-RGD NPs could efficiently accumulate in gastric cancer tissues and cells via RGD mediation, and immediately significantly increased the MRI effects. Through this study, we can conclude that Mn 3 O 4 @PEG-RGD NPs have the potential to be a novel MRI contrast agent for the postoperative monitoring of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Wang

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

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Nanoparticles to Deal with Gastric Cancer

Cited by 1 publication

References 45 publications

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring via Magnetic Resonance Imaging

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