Delivery of tissue plasminogen activator and streptokinase magnetic nanoparticles to target vascular diseases

Tadayon, Ateke; Jamshidi, Reza; Esmaeili, Akbar

doi:10.1016/j.ijpharm.2015.09.008

Cited by 47 publications

(27 citation statements)

References 23 publications

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“…Plants produce phenolic compounds which have significant antioxidant properties . The TP content of MC films with and without incorporated NCS containing EO was measured.…”

Section: Resultsmentioning

confidence: 99%

Optimization and preparation of Methylcellulose edible film combined with of Ferulago angulata essential oil (FEO) nanocapsules for food packaging applications

Esmaeili

Fazel

2016

Flavour & Fragrance J

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The films based on methylcellulose with biodegradable and antioxidant activity incorporated with nano capsule suspension containing F. angulata essential oil were developed. Oil extraction and identification of F. angulata essential oil compounds was done. Nano capsule suspension containing F. angulata essential oil was prepared by ultrasonic bath. The films were prepared by a casting method in three different ratios. The mechanical properties, colour, light transmission, antioxidant activity and release rate characteristics of the films were studied. The addition of nano capsule suspension to methylcellulose films decreased the thickness, tensile strength but increased the percentage elongation at break (%E) and lightness. High antioxidant activity and a prolonged release of F. angulata essential oil were also reported. Five factors design of Response Surface Methodology were used to optimize the thickness, holding time and anti-oxidant effect of edible film based on methylcellulose incorporated with nano capsule suspension containing F. angulata essential oil. Design of experiments was carried out by the software: Minitab 17 (Sigma package). Optimization of thickness, 2, 2-diphenyl-1-picrylhydrazyl radical scavenging and holding time would yield the best mixture proportions of methylcellulose and nano capsule suspension 30%, 30% and 70%; oil<0.05, 0.07 and 0.05 mg; at 20, 24 and 24 min; 50°, 40°, 50°C were obtained respectively.

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“…Plants produce phenolic compounds which have significant antioxidant properties . The TP content of MC films with and without incorporated NCS containing EO was measured.…”

Section: Resultsmentioning

confidence: 99%

Optimization and preparation of Methylcellulose edible film combined with of Ferulago angulata essential oil (FEO) nanocapsules for food packaging applications

Esmaeili

Fazel

2016

Flavour & Fragrance J

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“…As in other fibrinolytic particles discussed previously, encapsulating or immobilizing PA on MNP increases enzyme stability during storage and improves half‐life . Magnetic nanoparticles carrying tPA, uPA, or SK have been decorated with coatings that further improve half‐life and reduce immunogenicity including dextran, chitosan, silica, hydrosol, PLGA and PLA‐PEG, polyacrylic acid (PAA), PEG, poly[aniline‐co‐N‐(1‐one‐butyric acid) aniline], and heparin . Plasminogen activator functionalization of MNP can rely on either physical adsorption to the MNP matrix or covalent attachment .…”

Section: Magnetic Particles and Magnetic Field Controlmentioning

confidence: 99%

“…The simplest form of magnetic control is to use a permanent magnet to establish a magnetic field gradient to move MNP toward a target (Figure A, Table ). This is the most widely reported method for manipulating PA carriers . Ma et al.…”

Section: Magnetic Particles and Magnetic Field Controlmentioning

confidence: 99%

“…This is the most widely reported method for manipulating PA carriers. 79,81,87,88,91 Ma et al used PAA particles conjugated with tPA to show recanalization of the iliac artery in rats and demonstrated reperfusion using only 20% of the therapeutic tPA concentration (1 mg/kg). 86 Experiments in rat and mouse models also use a moving permanent magnet to drag MNP from the drug injection site to the thrombus.…”

Section: Magnetic Field Control Of Magnetic Particlesmentioning

confidence: 99%

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Engineered microparticles and nanoparticles for fibrinolysis

Disharoon

Marr

Neeves

2019

Journal of Thrombosis and Haemostasis

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Fibrinolytic agents including plasmin and plasminogen activators improve outcomes in acute ischemic stroke and thrombosis by recanalizing occluded vessels. In the decades since their introduction into clinical practice, several limitations of have been identified in terms of both efficacy and bleeding risk associated with these agents. Engineered nanoparticles and microparticles address some of these limitations by improving circulation time, reducing inhibition and degradation in circulation, accelerating recanalization, improving targeting to thrombotic occlusions, and reducing off‐target effects; however, many particle‐based approaches have only been used in preclinical studies to date. This review covers four advances in coupling fibrinolytic agents with engineered particles: (a) modifications of plasminogen activators with macromolecules, (b) encapsulation of plasminogen activators and plasmin in polymer and liposomal particles, (c) triggered release of encapsulated fibrinolytic agents and mechanical disruption of clots with ultrasound, and (d) enhancing targeting with magnetic particles and magnetic fields. Technical challenges for the translation of these approaches to the clinic are discussed.

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“…Delivery of drugs other than chemotherapeutic agents is possible, too. 24 In addition, the endoscopic magnetotargeted delivery can be combined with immunologicaltargeted delivery by linking with tumor-specific antibodies. 25 Hereby, the SPION may first be guided to the tumor site with magnetic forces and thereafter target even more specifically only a certain cell type in the tumor microenvironment.…”

Section: Biophysical Model and Simulationsmentioning

confidence: 99%

Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

Roeth

Slabu

Baumann

et al. 2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPION) may be used for local tumor treatment by coupling them to a drug and accumulating them locally with magnetic field traps, that is, a combination of permanent magnets and coils. Thereafter, an alternating magnetic field generates heat which may be used to release the thermosensitively bound drug and for hyperthermia. Until today, only superficial tumors can be treated with this method. Our aim was to transfer this method into an endoscopic setting to also reach the majority of tumors located inside the body. To find the ideal endoscopic magnetic field trap, which accumulates the most SPION, we first developed a biophysical model considering anatomical as well as physical conditions. Entities of choice were esophageal and prostate cancer. The magnetic susceptibilities of different porcine and rat tissues were measured with a superconducting quantum interference device. All tissues showed diamagnetic behavior. The evaluation of clinical data (computed tomography scan, endosonography, surgical reports, pathological evaluation) of patients gave insight into the topographical relationship between the tumor and its surroundings. Both were used to establish the biophysical model of the tumors and their surroundings, closely mirroring the clinical situation, in which we could virtually design, place and evaluate different electromagnetic coil configurations to find optimized magnetic field traps for each tumor entity. By simulation, we could show that the efficiency of the magnetic field traps can be enhanced by 38-fold for prostate and 8-fold for esophageal cancer. Therefore, our approach of endoscopic targeting is an improvement of the magnetic drug-targeting setups for SPION tumor therapy as it holds the possibility of reaching tumors inside the body in a minimal-invasive way. Future animal experiments must prove these findings in vivo.

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Delivery of tissue plasminogen activator and streptokinase magnetic nanoparticles to target vascular diseases

Cited by 47 publications

References 23 publications

Optimization and preparation of Methylcellulose edible film combined with of Ferulago angulata essential oil (FEO) nanocapsules for food packaging applications

Optimization and preparation of Methylcellulose edible film combined with of Ferulago angulata essential oil (FEO) nanocapsules for food packaging applications

Engineered microparticles and nanoparticles for fibrinolysis

Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

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