Delivery of small interfering RNAs by nanovesicles for cancer therapy

Probing the elastic response of lipid bilayers and nanovesicles to leaflet tensions via volume per lipid

“…The areas per lipid are computed using eqn (32) and (33). The leaflet tensions are obtained from the decomposition of the bilayer tension, S = S il + S ol , as described by eqn (48) in the Methods section, where the radius R mid of the midsurface is determined by eqn ( 28) and (29). Inspection of Fig.…”

“…39–43 In particular, they have been applied to a variety of skin diseases such as skin cancer 44 and psoriasis. 45 More recently, such nanovesicles have emerged as nanocarriers for the packaging and delivery of small interfering RNA therapeutics, used to silence various pathways of gene expression, 46–48 and for the delivery of mRNA vaccines, which became crucial during the COVID-19 pandemic. 47,49,50…”

Photochemical Internalization of siRNA for Cancer Therapy

“…RNAi mediates its action through non-coding short double-stranded RNA (nc-sdRNA) such as small-interfering RNA (siRNA) and microRNAs (miRNA). Single miRNA can inhibit the expression of several target genes simultaneously; however, to trigger gene silencing; siRNA is considered more efficient and specific than miRNA [ 14 ].…”

“…Its essential therapeutic strategy stems from its ability to suppress oncogenes and mutated tumor suppressor genes, as well as genes involved in MDR mechanism, resulting in the sensitization of cancer cells to treatment [ 19 , 20 ]. Anticancer siRNA targets can be categorized into (i) molecules involved in carcinogenesis, including molecules involved in oncogenic pathways, regulation of cell cycle, and apoptosis pathway; (ii) molecules involved in tumor–host interaction such as in cell adhesion, tumor extracellular matrix, tumor immune evasion, angiogenesis, invasion, and metastasis; and (iii) molecules participated in tumor resistance to chemotherapy, such as MDR and DNA repair proteins [ 14 ].…”

Polyamidoamine-Carbon Nanodot Conjugates with Bioreducible Building Blocks: Smart Theranostic Platforms for Targeted siRNA Delivery

“…Despite numerous examples where viral vectors have proven to be valuable tools for siRNA delivery, the issues associated with viral vectors, such as, for example, the high immunoge-nicity and potential host immune responses, have led scientists to develop nonviral systems, which are considered to be much safer than viral systems. 12,13 On this ground, polymers offer numerous advantages over nonviral vectors, as they can load higher amount of oligonucleotides and can be chemically modified to produce systems tailored to target specific tumors. 14 Among them, amphoteric poly(amidoamine)s (PAAs) are a class of biocompatible and biodegradable synthetic polymers that are of great interest due to their high transfection efficiency for siRNA.…”