Polyamidoamine-Carbon Nanodot Conjugates with Bioreducible Building Blocks: Smart Theranostic Platforms for Targeted siRNA Delivery
Salvatore Emanuele Drago,
Mara Andrea Utzeri,
Nicolò Mauro
et al.
Abstract:This study focuses
on designing hybrid theranostic nanosystems,
utilizing gadolinium-doped carbon nanodots decorated with bioreducible
amphoteric polyamidoamines (PAAs). The objective is to synergize the
exceptional theranostic properties of gadolinium-doped carbon nanodots
(CDs) with the siRNA complexation capabilities of PAAs. Linear copolymeric
polyamidoamines, based on N,N′-bis(acryloyl)cystamine,
arginine, and agmatine, were synthesized, resulting in three distinct
amphoteric copolymers. Notably, sulfur b… Show more
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