Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes

Liu, Jianye; Zhang, Yi; Zeng, Qinghai; Zeng, Hongliang; Liu, Xiaoming; Wu, Pei Hsun; Xie, Hong-Yi; He, Leye; Li, Zhi; Lu, Xiaoyong; Xiao, Mengqing; Zhu, Yuxing; Bo, Hao; Cao, Ke

doi:10.1126/sciadv.aaw6499

Cited by 46 publications

(31 citation statements)

References 38 publications

(46 reference statements)

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“…(ii) In HNTs, there were different chemical constituents. The Si-O-Si groups on the external surface and Al-OH groups on the internal surface determined the negatively charged outer surface of the HNMs, resulting in an increase in the spindle-knot surface polarity [28,41]. (iii) The surface energy of the NFs was well fitted with Wenzel's law:…”

Section: Filtration Stability and Wettability Of Hnm-nf Filtermentioning

confidence: 94%

Electrospinning with a spindle-knot structure for effective PM2.5 capture

et al. 2020

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Long-term air contamination and pollution challenges in particulate matter (PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the PM. The desired air filter, seeking both high filtration efficiency and low pressure drop remains challenging. Here, we report a bio-inspired spindle-knot halloysite nanotube microsphere-incorporated nanofiber (HNM-NF) filter with the assembly and shape structures of the spider silk. The resulting HNM-NFs exhibit integrated properties of high surface energy, hydrophilicity and strong PM capture. The spindle-knot structures could shrink the outer pore size on two-dimensional (2D) surface and construct the fluffy 3D reticular architecture, facilitating high-efficiency air pollutant capture (>85.0%) while maintaining low resistance to airflow (~39 Pa). The spindle-knot construction method was applicable to various materials (i.e., Al 2 O 3 , ZnO and TiO 2 ) and volume production of the microsphere-incorporated NF cartridge. The diversified spindleknot construction will be valuable for adapting to meet different filtration requirements.

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Section: Filtration Stability and Wettability Of Hnm-nf Filtermentioning

confidence: 94%

Electrospinning with a spindle-knot structure for effective PM2.5 capture

et al. 2020

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“…Natural halloysite nanotube (HNT)assisted delivery of an active small interfering RNA targeting RIPK4 efficiently inhibited RIPK4 expression in vivo and suppressed bladder cancer tumorigenesis and progression with no adverse effects. Further analysis indicated that the NF-κB signaling pathway might be involved as the downstream pathway for the regulation of proliferation and progression in bladder cancer (64). RIPK4 is a critical activator of NF-κB signaling, which contributes to cancer development and progression, as well as to the resistance of cancer cells to chemoradiotherapy (65).…”

Section: Discussionmentioning

confidence: 99%

Insight Into the Function of RIPK4 in Keratinocyte Differentiation and Carcinogenesis

Wei

2020

Front. Oncol.

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The receptor-interacting protein kinase 4 (RIPK4), a member of the RIPK family, was originally described as an interaction partner of protein kinase C (PKC) β and PKCδ. RIPK4 is identified as a key regulator of keratinocyte differentiation, cutaneous inflammation, and cutaneous wound repair. The mechanism by which RIPK4 integrates upstream signals to initiate specific responses remains elusive. Previous studies have indicated that RIPK4 can regulate several signaling pathways, including the NF-κB, Wnt/β-catenin, and RAF/MEK/ERK pathways. Furthermore, RIPK4-related biological signaling pathways interact with each other to form a complex network. Mounting evidence suggests that RIPK4 is aberrantly expressed in various kinds of cancers. In several types of squamous cell carcinoma (SCC), the mutations that drive aggressive SCC have been found in RIPK4. In addition, the function of RIPK4 in carcinogenesis is probably tissue-specific, since RIPK4 can play a dual role as both a tumor promoter and a tumor suppressor in different tumor types. Therefore, RIPK4 may represent as an independent prognostic factor and a promising novel therapeutic target, which can be used to identify the risks of patients and guide personalized treatments. In future, RIPK4-interacting pathways and precise molecular targets need to be investigated in order to further elucidate the mechanisms underlying epidermal differentiation and carcinogenesis.

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“…In brief, the strategy of using nanoparticles for the delivery of siRNA significantly improved the potential of siRNA in cancer therapy [ 142 ].These nanostructures were in fact applied in clinical trials for the delivery of siRNA with high efficiency [ 143 , 144 ]. To date, various nanoparticles such as polymeric nanoparticles, lipid nanoparticles, carbon nanotubes, and gold nanoparticles were designed for the delivery of siRNA [ 51 , 88 , 145 , 146 , 147 , 148 ]. These nano-vehicles provide protection for the siRNA against degradation and a reduction of the off-target effects via delivery to targeted sites [ 149 , 150 ].…”

Section: The Dark Side Of Sirna Delivery System: Challenges and Opmentioning

confidence: 99%

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

et al. 2020

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Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the off-target effects of siRNA therapy remarkably reduce its efficacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The efficacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types.

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Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes

Cited by 46 publications

References 38 publications

Electrospinning with a spindle-knot structure for effective PM2.5 capture

Electrospinning with a spindle-knot structure for effective PM2.5 capture

Insight Into the Function of RIPK4 in Keratinocyte Differentiation and Carcinogenesis

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

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