Delivery of Platinum(IV) Prodrugs via Bi₂Te₃ Nanoparticles for Photothermal–Chemotherapy and Photothermal/Photoacoustic Imaging

Abstract

Combinational administration of photothermal therapy (PTT) and chemotherapy (CT) shows great potential in improving the efficiency of tumor treatment. Herein, we designed a novel nanocomposite Pt@Bi 2 Te 3 composed of bismuth telluride (Bi 2 Te 3 ) nanoparticles and platinum(IV) prodrugs (Pt) for PTT−CT combination therapy. The obtained Bi 2 Te 3 was synthesized by a simple solvothermal method and modified by polyethylene glycol, which exhibited excellent photothermal (PT) efficiency and stability and could also serve as a bimodal bioimaging contrast agent in PT and photoacoustic (PA) imaging. In vitro experiment results showed that the nanocomposite Pt@ Bi 2 Te 3 could effectively increase the uptake of platinum in cancer cells, which could kill tumor cells through the combined effect of PTT and CT. Furthermore, combination therapy of cancer in vivo was achieved with obvious tumor-growth inhibition without inducing observed side effects. We revealed the great potential of Bi 2 Te 3 nanocomposites in increasing therapeutic efficiency by PTT−CT therapy and PA− PT imaging.

Thermosensitive drug-loaded liposomes for photothermal and chemotherapeutic treatment of colon cancer

“…Among these materials, bismuthene nanosheets stand out due to their low toxicity and cost-effectiveness. 30 However, there is currently limited research on the utilization of bismuthene nanosheets in biomedicine. In this study, we focused on the preparation of bismuthene nanosheets (BiNSs) and the self-assembly of thermosensitive liposomes with small molecule anticancer drugs, namely 5-fluorouracil (5-FU) and metformin (Met).…”

Pt(II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer

“…Passive targeting can be enhanced using an active targeting approach, wherein ligands are implanted onto the NP’s surface, thus increasing the NPs uptake by cancer cells via receptor-mediated endocytosis [ 16 , 17 ]. The NP-based delivery of platinum agents has been previously explored [ 18 , 19 ], including liposome- [ 20 , 21 ], polymeric- [ 22 , 23 ], Bi 2 Te 3 - [ 24 ], or chitosan-based [ 25 ] NPs. Additionally, the use of biological [ 26 ] or inorganic carriers [ 27 , 28 ] have been reported.…”

Broadband All-Optical THz Modulator Based on Bi2Te3/Si Heterostructure Driven by UV-Visible Light

“…Bi 2 Te 3 is a V–VI compound topological material with unique electrical and optical properties, including high carrier mobility, tunable bandgap, high conductivity, and single Dirac cone [ 27 , 28 , 29 ]. Recently, it has received enormous attention in photoelectric applications such as ultrafast laser photonics, optical communications, infrared sensors, and biomedical imaging [ 30 , 31 , 32 ]. In the THz region, 2D Bi 2 Te 3 has proven to be a promising candidate for broadband photodetection [ 33 ], chiral THz emitter [ 34 ], and high-speed spintronic devices [ 35 ].…”