Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries

Castangia, Inés; Caddeo, Carla; Manca, Maria Letizia; Casu, Laura; Latorre, Ana Catalan; Dı́ez-Sales, Octavio; Ruiz‐Saurí, Amparo; Bacchetta, Gianluigi; Fadda, Anna Maria; Manconi, Maria

doi:10.1016/j.carbpol.2015.08.037

Cited by 89 publications

(68 citation statements)

References 20 publications

(4 reference statements)

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“…The vesicle dispersions (2 mL) were purified from the non-incorporated active components by dialysis against water (4 L) at 25 • C for 3 h (with water refreshed every 30 min.) by using Spectra/Por ® membranes (12-14 kDa MW cut-off, 3 nm pore size; Spectrum Laboratories Inc., DG Breda, the Netherlands) [2,18]. The non-dialysed and dialysed vesicles were diluted with methanol and the amounts of citral or the main components of the pompia essential oil were quantified by gas chromatography, as reported in Section 2.3, to determine entrapment efficiency (EE), which was calculated as the percentage of the active components recovered in the dialysed samples versus the amounts that were found in non-dialysed samples.…”

Section: Vesicle Preparationmentioning

confidence: 99%

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

et al. 2020

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Citrus species extracts are well known sources of bio-functional compounds with health-promoting effects. In particular, essential oils are known for their antibacterial activity due to the high content of terpenes. In this work, the steam-distilled essential oil from the leaves of Citrus limon var. pompia was loaded in phospholipid vesicles. The physico-chemical characteristics of the essential oil loaded vesicles were compared with those of vesicles that were loaded with citral, which is one of the most abundant terpenes of Citrus essential oils. The biocompatibility of the vesicles was assessed in vitro in human keratinocytes. Furthermore, the antimicrobial activity of the vesicles was tested while using different bacterial strains and a yeast: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, respectively. The vesicles were small in size (~140 nm), slightly polydispersed (PI~0.31), highly negatively charged (~−73 mV), and able to incorporate high amounts of essential oil or citral (E%~86%). Pompia essential oil and citral exhibited antimicrobial activity against all of the assayed microorganisms, with P. aeruginosa being the least sensitive. Citral was slightly more effective than pompia essential oil against E. coli, S. aureus, and C. albicans. The incorporation of citral in vesicles improved its antifungal activity against C. albicans.

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Section: Vesicle Preparationmentioning

confidence: 99%

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

et al. 2020

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“…These phenolic compounds are effective in the protection of biological systems against oxidative stress, being able to inhibit the onset of skin damages (Haraguchi et al, ). According to Castangia et al (), the topical application of liquorice extract formulations may be of value in innovative dermal and cosmetic products as it counteracts oxidative stress damage, maintaining the skin homeostasis due to its high antioxidant content. Table summarizes the most important studies of antioxidant activity.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Pastorino

Cornara

Soares

et al. 2018

Phytotherapy Research

454

323

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In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β-glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra. Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well-being.

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“…It was shown that G. glabra, is effective for the treatment of skin diseases such as dermatitis, eczema and psoriasis. Glycyrrhizin by inhibiting local inflammatory pathogens treat skin injuries [34].…”

Section: Discussionmentioning

confidence: 99%

Licorice cream promotes full-thickness wound healing in Guinea pigs

Hanafi¹,

Amiri²,

Shahani³

et al. 2018

jrp

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Impaired wound healing may cause economic and social problems and seriously reduce the quality of life. The uses of herbal medicines as new alternative treatments are under investigation. This study investigated the effect of Glycyrrhiza glabra L. extract on the full-thickness wound healing in Guinea Pig model. Eight male Guinea Pigs (700-800 g) were used to be creared a square full-thickness wound with 1.5 ×1.5 dimensions on the lumbodorsal area. The wounds were randomly divided into four groups: I; control, II; 1% phenytoin, III; 5% G. glabra and IV; 10 % G.glabra. On day 3, 5, 7, 9 and 12, wound size was measured for assessment of the percent of wound healing. In order to determine the wound healing activity, excisional biopsies were evaluated histopathologically on the 12th days of treatments. Acute inflammation, granulation tissue fibroblast maturation, collagen deposition, epidermal layer formation, neovascularization, keratin layer formation were evaluated according to the Abramov score method. Hydroalcoholic extract of G.glabra exhibited total phenolic and flavonoid contents of 114.1 ± 5.45 and 82.85 ± 6.38 mg, respectively. G.glabra creams (5% and 10% w/w)were significantly increased the epidermal formation, collagen deposition and neovascularization, and was decreased acute inflammation in comparison to the control group. Wound healing rate were increased in the G. glabra groups. G.glabra creams 10 % was more effective than 5% w/w. Our findings proved that 5% and 10% w/w G. glabra creams were effective in acute dermal wound healing. More studies with different doses of G. glabra extract are recommended.

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Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries

Cited by 89 publications

References 20 publications

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Licorice cream promotes full-thickness wound healing in Guinea pigs

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