Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients

Thombre, Avinash G.; DeNoto, A.R.; Gibbes, D.C.

doi:10.1016/s0168-3659(99)00086-3

Cited by 48 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the physical design of an AM dosage form is flexible-it is possible to adopt the technology to fabricate coatings on tablets or on small particles, or to fabricate osmotic capsules directly from the asymmetric polymer membrane. The asymmetric membrane capsule (AMC) is an example of a single core osmotic delivery system consisting of a drug containing core surrounded by an asymmetric membrane i.e., it has a relatively thin, dense region supported on a thicker, porous region [5,6]. The use of AMC primarily has been for *Address correspondence to this author at the Rajiv Academy for Pharmacy, Delhi-Mathura Highway, Mathura (U.P.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric Membrane Capsules of Phenylephrine Hydrochloride: An Osmotically Controlled Drug Delivery System

Kumar¹,

Philip²,

Pathak

2011

CDD

View full text Add to dashboard Cite

The aim of the current study was to develop osmotically controlled release system of freely water soluble drug phenylephrine hydrochloride by use of asymmetric membrane capsules to reduce the dosing frequency and consequently improve the patient compliance. Ethyl cellulose asymmetric membrane capsules were developed by phase inversion process and solubility modulation was accomplished by common ion effect wherein sodium chloride was included in the formulation that also served as an osmogen. The effect of formulation variables namely level of polymer (ethyl cellulose), level of pore former (glycerol) and level of osmogen (sodium chloride) on the in vitro release of the drug was evaluated by 2(3) factorial design. Effects of environmental factors on the release rate of the drug from asymmetric membrane capsules were also evaluated. Membrane characterization by scanning electron microscopy showed an outer dense region with less pores and inner porous region for the prepared asymmetric membrane. The dimensional analysis of asymmetric membrane capsule documented the capsules to be of uniform cap and body size comparable to commercial hard gelatin capsules. In vitro release studies results showed that incorporation of higher amount of osmogen not only increased the osmotic pressure but also controlled the drug release for a period of 12 hr. The drug release was inversely proportional to the level of polymer in asymmetric membrane capsule but directly related to the level of pore former in the membrane. The optimized asymmetric membrane capsule (F5) was able to provide zero order release of phenylephrine hydrochloride independent of agitation rate, intentional defect in the membrane and pH of dissolution medium but was dependent on the osmotic pressure gradient between inside and outside of the delivery system.

show abstract

Section: Introductionmentioning

confidence: 99%

Asymmetric Membrane Capsules of Phenylephrine Hydrochloride: An Osmotically Controlled Drug Delivery System

Kumar¹,

Philip²,

Pathak

2011

CDD

View full text Add to dashboard Cite

show abstract

“…Researchers have formulated oral controlled-release products of glipizide by various techniques. 12,19,20 Moreover, the site of absorption of glipizide is in the stomach. Dosage forms that are retained in the stomach would increase the absorption, improve drug efficiency, and decrease dose requirements.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive glipizide microspheres

Patel¹,

Patel²,

Amin

et al. 2005

AAPS PharmSciTech

View full text Add to dashboard Cite

The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-linking, polymer-to-drug ratio, and speed of rotation affected characteristics of microspheres. Microspheres were discrete, spherical, and free flowing. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test and also showed a high percentage drug entrapment efficiency. A 3 2 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X 1 ), and stirring speed (X 2 ) on dependent variables percentage mucoadhesion, t 80 , drug entrapment efficiency, and swelling index. The best batch exhibited a high drug entrapment efficiency of 75% and a swelling index of 1.42; percentage mucoadhesion after 1 hour was 78%. The drug release was also sustained for more than 12 hours. The polymer-to-drug ratio had a more significant effect on the dependent variables. In vivo testing of the mucoadhesive microspheres to albino Wistar rats demonstrated significant hypoglycemic effect of glipizide.

show abstract

“…Dosage forms that are retained in the stomach would increase the absorption, improve drug efficiency,and decrease dose requirements. Thus, an attempt was made in this investigation to use chitosan as a mucoadhesive polymer and prepare microspheres 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Entrapment Efficiency of Glipizide Microsphere

Arora¹

2012

iosrphr

View full text Add to dashboard Cite

Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients

Cited by 48 publications

References 8 publications

Asymmetric Membrane Capsules of Phenylephrine Hydrochloride: An Osmotically Controlled Drug Delivery System

Asymmetric Membrane Capsules of Phenylephrine Hydrochloride: An Osmotically Controlled Drug Delivery System

Formulation and evaluation of mucoadhesive glipizide microspheres

Evaluation of Entrapment Efficiency of Glipizide Microsphere

Contact Info

Product

Resources

About