Delivery of fungal .BETA.-galactosidase to rat brain by means of liposomes.

Takada, Goro; Onodera, Hidetoshi; Tada, Keiya

doi:10.1620/tjem.136.219

Cited by 13 publications

(6 citation statements)

References 7 publications

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“…Nucleic acids ( 14,15), proteins (16), and antitumor drugs (17) can become cellassociated and biologically active, both in vitro and in vivo, using liposomes as transmembrane vectors. The intracellular content of these macromolecules can be increased severalfold.…”

mentioning

confidence: 99%

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

Turrens¹,

Crapo²,

Freeman³

1984

J. Clin. Invest.

456

141

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Absra act. Survival of rats exposed to 100% oxygen was increased from 69.5±1.5 to 118.1±9.9 h (mean±SEM, P < 0.05) when liposomes containing catalase and superoxide dismutase were injected intravenously before and during exposure. The increased survival time in 100% oxygen was also associated with significantly less fluid in the pleural cavity. Rats injected with catalaseand superoxide dismutase-containing liposomes, which had increased survival in 100% oxygen, had increased lung wet weight upon autopsy compared with saline-injected controls (2.9±0.2 g/lung vs. 4.8±0.4 g/lung, mean±SE, P < 0.05). Intravenous injection of control liposomes along with catalase and superoxide dismutase in the suspending buffer decreased the mean pleural effusion volume 89% and had no significant effect on survival time. Lung catalase and superoxide dismutase activities were increased 3.1-and 1.7-fold, respectively, 2 h after a single intravenous injection of liposomes containing catalase or superoxide dismutase. Superoxide dismutase activity was also significantly greater than controls in both air-and 100% oxygen-exposed rat lungs, when enzyme activity was assayed 24 h after cessation of injection of control and oxygen-exposed rats with enzymecontaining liposomes every 12 h for 36 h. Free superoxide dismutase and catalase injected intravenously in the absence of liposomes did not increase corresponding lung enzyme activities, affect pleural effusion volume, lung wet weight, or extend the mean survival time of rats Preliminary results of these studies were presented at the Third International Conference on superoxide and superoxide dismutases, Ellenville, NY, October 1982.

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mentioning

confidence: 99%

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

Turrens¹,

Crapo²,

Freeman³

1984

J. Clin. Invest.

456

141

View full text Add to dashboard Cite

show abstract

“…In this respect, there are few studies on experimental animals (Barranger et al 1980; Rattazzi et al 1981). In our previous work (Takada et al 1981(Takada et al , 1982) regarding this fundamental problem whether the administered enzyme penetrate the blood-brain barrier, we presented biochemical evidence that exogenous enzyme can enter the brain by using the liposome-entrapped enzyme.…”

mentioning

confidence: 99%

Microautoradiographic study on the tissue localization of liposome-entrapped or unentrapped 3H-labeled .BETA.-galactosidase injected into rats.

Onodera

Takada

Tada

et al. 1983

Tohoku J. Exp. Med.

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“…Although it was previously reported that liposome uptake by capillary endothelial cells is nearly absent in the brain (McLean et al, 1997), the typical liposome injection study does not measure CBF (Mamot et al, 2003;Takada et al, 1982). Previous studies (Yoshimura et al, 2002) demonstrated a CBF increase following liposome infusion; however, the method used for measurement (laser Doppler flow with a probe) can measure only a very small volume (1.5 mm 3 ).…”

Section: Discussionmentioning

confidence: 99%

Cerebrovascular Involvement in Liposome—Induced Cardiopulmonary Distress in Pigs

Bodó

Szebeni

Baranyi

et al. 2005

Journal of Liposome Research

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The public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, 14. ABSTRACT Intravenous administration of liposomes, including Doxil, can cause severe life threatening hemodynamic changes in pigs. The reaction is due to complement activation, and it is characterized by massive pulmonary hypertension, systemic hypotension and severe cardiac abnormalities including falling cardiac output, tachy-or bradycardia with arrhythmia. There were no data suggesting the involvement of cerebrovascular changes in this reaction, however clinical observations allowed this hypothesis. Here we measured the accompanying changes during liposome infusion by monitoring pulsatile electrical impedance (rheoencephalogram -REG) on the skull (n = 24 pigs, 57 trials, 19 types of liposomes). A transient but significant decrease of REG pulse amplitudes followed the injection of liposomes (78.43 % in the total sample, and 91.66 % in the Doxil subgroup; P = 0.003, n = 12), indicating the involvement of cerebrovascular reaction during liposome infusion.

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Delivery of fungal .BETA.-galactosidase to rat brain by means of liposomes.

Cited by 13 publications

References 7 publications

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

Microautoradiographic study on the tissue localization of liposome-entrapped or unentrapped 3H-labeled .BETA.-galactosidase injected into rats.

Cerebrovascular Involvement in Liposome—Induced Cardiopulmonary Distress in Pigs

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