Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

Luther, David C.; Huang, Rui; Jeon, Taewon; Zhang, Xianzhi; Lee, Yi-Wei; Nagaraj, Harini; Rotello, Vincent M.

doi:10.1016/j.addr.2020.06.020

Cited by 208 publications

(141 citation statements)

References 403 publications

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“…Chemotherapeutic drugs fail to activate or alter drug-appointed targets and enhanced drug efflux from the drug accumulation regions, are the established mechanisms that markedly lower anticancer efficiencies in tumors (Lepeltier et al, 2020). In the current researches of cancer medicine, significant efforts have been devoted to explore smart nanoparticles for an effective targeted drug delivery system (TDDS) (Luther et al, 2020). In designing nanomedicines, there are several points to be considered, such as preferential concentration in the tumor tissue, efficient internalization into cancer cells, and accurate subcellular location of drugs at their site of actions.…”

Section: Gold Nanoparticles In Therapy Drug Deliverymentioning

confidence: 99%

Gold Nanoparticles in Cancer Theranostics

Gao

Zhang

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs’ unrivaled control for effective transport of therapeutic cargos. In this review article, we primarily introduce the basic properties of GNPs, further discuss the recent progress in gold nanoparticles for cancer theranostics, with an additional concern about TME stimuli-responsive studies.

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Section: Gold Nanoparticles In Therapy Drug Deliverymentioning

confidence: 99%

Gold Nanoparticles in Cancer Theranostics

Gao

Zhang

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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“…[ 59,81 ] Recent reviews have been devoted to discuss the applications of inorganic nanomaterials in the biomedical and pharmaceutical areas. [ 84,93,94 ]…”

Section: Nanomaterialsmentioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

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3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus‐response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.

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“…Nanomaterials can inhibit viral replication by interacting with the viral protein/genome or inducing a suppressive environment for intracellular viral replication. AuNPs arrest foot-and-mouth disease virus (FMDV) replication at the post-entry stage and block viral transcription in the host cell by binding to FMDV RNA, sub-genomic RNA, or viral replicative proteins via electrostatic interactions [ 54 , 55 ]. Moreover, several fullerene derivatives can affect the maturation of both wild-type HIV-1 and drug-resistant HIV-1 by inhibiting Gag polyprotein processing, which generates the matrix, capsid, nucleocapsid, and p6 gag proteins required for a functional virus, thereby hindering viral replication [ 56 ].…”

Section: Antiviral Effects Of Nanomaterialsmentioning

confidence: 99%