Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review

Bashyal, Santosh; Lee, Sang Kil

doi:10.1007/s40005-015-0219-7

Cited by 13 publications

(7 citation statements)

References 157 publications

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“…Among these, lipid-based nanocarriers, particularly liposomes that are composed of natural or synthetic phospholipids, with or without cholesterol, have shown tremendous potential in increasing the permeability and bioavailability of peptide drugs [ 11 , 12 , 13 ]. Liposomes have been reported as attractive nanocarrier systems that can deliver drug molecules via various noninvasive routes, including oral, transdermal, nasal, and buccal routes [ 14 , 15 , 16 ]. Since the phospholipid is the main component of the cellular membrane, liposomes have been gaining popularity due to their biocompatibility, biodegradability, low toxicity, as well as amphiphilic attributes that allow for the encapsulation of both lipophilic and hydrophilic drugs [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

et al. 2021

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Buccal drug delivery is a suitable alternative to invasive routes of drug administration. The buccal administration of insulin for the management of diabetes has received substantial attention worldwide. The main aim of this study was to develop and characterize elastic liposomes and assess their permeability across porcine buccal tissues. Sodium-cholate-incorporated elastic liposomes (SC-EL) and sodium-glycodeoxycholate-incorporated elastic liposomes (SGDC-EL) were prepared using the thin-film hydration method. The prepared liposomes were characterized and their ex vivo permeability attributes were investigated. The distribution of the SC-EL and SGDC-EL across porcine buccal tissues was evaluated using confocal laser scanning microscopy (CLSM). The SGDC-EL were the most superior nanocarriers since they significantly enhanced the permeation of insulin across porcine buccal tissues, displaying a 4.33-fold increase in the permeability coefficient compared with the insulin solution. Compared with the SC-EL, the SGDC-EL were better at facilitating insulin permeability, with a 3.70-fold increase in the permeability coefficient across porcine buccal tissue. These findings were further corroborated based on bioimaging analysis using CLSM. SGDC-ELs showed the greatest fluorescence intensity in buccal tissues, as evidenced by the greater shift of fluorescence intensity toward the inner buccal tissue over time. The fluorescence intensity ranked as follows: SGDC-EL > SC-EL > FITC–insulin solution. Conclusively, this study highlighted the potential nanocarriers for enhancing the buccal permeability of insulin.

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Section: Introductionmentioning

confidence: 99%

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

et al. 2021

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“…In such scenario, approaches incorporating the benefits of both active and passive methods of delivery rather than sticking to one particular type seem to be the wise alternative. By combining, liposomes with microneedles and iontophoresis, Bashyal and Lee showed that the flux of insulin was enhanced by 713.3-fold higher as compared to passive permeation [112]. Wang et al reviewed the combination of iontophoresis with multiple other techniques like chemical enhancers, even with other active strategies like sonophoresis, microneedle, electroporation and suggested this combination of techniques helps in more compliant and accurate delivery of macromolecules [113].…”

Section: Choice Of Active or Passive Deliverymentioning

confidence: 99%

Passive delivery of protein drugs through transdermal route

Chaulagain

Jain

Tiwari

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Skin is the largest external organ in the human body but its use for therapeutic purposes has been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and optimum polarity are fortunate enough to be used on skin therapeutics. But, at a time where modern therapeutics is slowly shifting from use of small molecular drugs towards the use of macromolecular therapeutic agents such as peptides, proteins and nucleotides in origin, skin therapeutics need to be evolved accordingly to cater the delivery of these agents. Physical technologies like iontophoresis, laser ablation, micro-needles and ultrasound, etc. have been introduced to enhance skin permeability. But their success is limited due to their complex working mechanisms and involvement of certain irreversible skin damage in some or other way. This review therefore explores the delivery strategies for transport of mainly peptide and protein drugs that do not involve any injuries (non-invasive) to the skin termed as passive delivery techniques. Chemical enhancers, nanocarriers, certain biological peptides and miscellaneous approaches like prodrugs are also thoroughly reviewed for their applications in protein delivery.

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“…All parameters required to increase lipophilicity and enhance drug permeability, such as molecular weight, H-bond donation, H-bond acceptance, and the log P value of DH, follow the Rule of Five. However, owing to the presence of a permeability barrier (the stratum corneum) in the skin, formulating a TDDS of DH is still a major concern for researchers [ 13,14]. Chemical permeability enhancers offer tremendous potential to overcome this limitation.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl

et al. 2020

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Transdermal delivery systems are emerging platforms for the delivery of donepezil hydrochloride (DH) for treating Alzheimer's disease. The primary aim of this study was to develop polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogels and to evaluate their feasibility for delivering DH via a transdermal route. Physicochemical properties, such as gel fraction (%), swelling ratio (%), weight loss (%), mechanical strength, elongation at break, and Young's modulus of the prepared hydrogels were evaluated. Furthermore, in vitro skin permeation and in vivo pharmacokinetic studies were performed. With an increased concentration of propylene glycol (PG), the gel fraction (%), maximum strength, and elongation at break decreased. However, the swelling ratio (%) and weight loss (%) of hydrogels increased with increased PG content. The 26% PG-hydrogel was superior, with an enhancement ratio of 12.9 (*** p < 0.001). In addition, the 11% PG-hydrogel and 1% PG-hydrogel exhibited an enhancement ratio 6.30-fold (*** p < 0.001) and 2.85-fold (* p < 0.05) higher than that exhibited by control, respectively, indicating a promising effect of PG on skin permeation. In addition, in vivo pharmacokinetic studies on hairless rats assessed the expediency for transdermal delivery of DH. The transdermal delivery of optimized hydrogel-patches with two different doses of DH revealed that the maximum plasma concentration and area under the curve were dose dependent, and the time to reach the maximum concentration was 8 h. Thus, optimized hydrogels have the potential to enhance the transdermal delivery of DH and could be a novel clinical approach.

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Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review

Cited by 13 publications

References 157 publications

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

Passive delivery of protein drugs through transdermal route

Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl

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