2000
DOI: 10.1046/j.1440-1819.2000.00775.x
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Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations

Abstract: The aim of this paper is to describe two cases of clomipramine-induced delirium. One 61-yearold and one 67-year-old female depressive patients became delirious after beginning intravenous clomipramine injections in addition to their oral clomipramine administrations. Their plasma levels of both clomipramine and its metabolite, desmethylclomipramine, were acutely increased about twofold during delirium. The intravenous clomipramine administrations were discontinued. Their delirious state was gradually improved … Show more

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