Delineation of the minimal region of loss at 13q14 in multiple myeloma

Elnenaei, Manal O.; Hamoudi, Rifat; Swansbury, John; Gruszka-Westwood, Alicja M.; Brito‐Babapulle, Vasantha; Matutes, Estella; Catovsky, Daniel

doi:10.1002/gcc.10140

Cited by 62 publications

(47 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The affected regions are variable and span large portions of 13q, ranging from 13q14 to 13q34. [34][35][36][37] These regions include many expressed sequence tags (ESTs) as well as known genes encoding for transcription factors and cell cycle regulators, such as retinoblastoma (RB1), Kruppel-like factor 12 (KLF12), ret finger protein 2 (RFP2), Drosophila dachshund homo- log 1 (DACH1), deleted in lymphocytic leukemia 1 and 2 (DLEU1 and DLEU2), and glypican 5 (GPC5), a gene with putative roles in the regulation of cell division and growth. 38 However, none of the studies addressing these specific genes have been able to find alterations, other than the monoallelic loss associated with the 13q deletions.…”

Section: Discussionmentioning

confidence: 99%

Secondary chromosomal abnormalities predict outcome in pediatric and adult high‐stage Burkitt lymphoma

Onciu

Schlette

Zhou

et al. 2006

Cancer

View full text Add to dashboard Cite

Recent studies suggest that the hypodigms representing the two earliest Australopithecus (Au. anamensis and Au. afarensis) form an ancestor‐descendant lineage. Understanding the details of this possible transition is important comparative evidence for assessing the likelihood of other examples of ancestor‐descendant lineages within the hominin clade. To this end we have analyzed crown and cusp base areas of high resolution replicas of the mandibular molars of Au. anamensis (Allia Bay and Kanapoi sites) and those of Au. afarensis (Hadar, Laetoli, and Maka). We found no statistically significant differences in crown areas between these hypodigms although the mean of M1 crowns was smaller in Au. anamensis, being the smallest of any Australopithecus species sampled to date. Intraspecies comparison of the areas of mesial cusps for each molar type using Wilcoxon signed rank test showed no differences for Au. anamensis. Significant differences were found between the protoconid and metaconid of Au. afarensis M2s and M3s. Furthermore, the area formed by the posterior cusps as a whole relative to the anterior cusps showed significant differences in Au. afarensis M1s and in Au. anamensis M2s but no differences were noted for M3s of either taxon. Developmental information derived from microstructural details in enamel shows that M1 crown formation in Au. anamensis is similar to Pan and shorter than in H. sapiens. Taken together, these data suggests that the overall trend in the Au. anamensis‐Au. afarensis transition may have involved a moderate increase in M1 crown areas with relative expansion of distal cusps. Am J Phys Anthropol , 2012. © 2012 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Secondary chromosomal abnormalities predict outcome in pediatric and adult high‐stage Burkitt lymphoma

Onciu

Schlette

Zhou

et al. 2006

Cancer

View full text Add to dashboard Cite

show abstract

“…3,4 The most frequently deleted genomic region in CLL occurs at chromosome 13q14 and is associated with the indolent form of the disease. 4 The same region is frequently found as the sole cytogenetic abnormality in other types of cancers: 50% of mantle cell lymphomas, 5 B30% of multiple myeloma, 6 and B60% of prostate cancers, 7 indicating that 13q14 contains an important tumor suppressor involved in the pathogenesis of these malignancies. A number of years ago, several laboratories used positional cloning and sequencing of a region of 41 Mb at the deleted region to identify a tumor-suppressor gene at 13q14.…”

Section: Mir-15/16 At 13q14 Gene Discoverymentioning

confidence: 99%

Role of miR-15/16 in CLL

2014

View full text Add to dashboard Cite

B-cell chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The most common chromosomal abnormalities detectable by cytogenetics include deletion at 13q (55%), 11q (18%), trisomy 12 (12-16%) and 17p (8%). In 2002, we discovered that a microRNA cluster miR-15a/miR-16-1 (miR-15/16) is the target of 13q deletions in CLL. MicroRNAs encoded by the miR-15/16 locus (miR-15 and miR-16) function as tumor suppressors. Expression of these miRNAs downregulated in CLL, melanoma, colorectal cancer, bladder cancer and other solid tumors. miR-15/16 cluster targets multiple oncogenes, including BCL2, Cyclin D1, MCL1 and others. The most important target of miR-15/16 in CLL is arguably BCL2, as BCL2 is overexpressed in almost all CLLs. In this review, we discuss the discovery, functions, clinical relevance and treatment opportunities related to miR-15/16.

show abstract

“…4 Several authors have reported that chromosome 13 abnormalities indicate an unfavorable prognosis in MM, [5][6][7][8] and various studies have shown that chromosome 13 deletions are early events and represent an adverse prognostic factor in the premalignant condition of monoclonal gammopathies of undetermined significance (MGUS).…”

mentioning

confidence: 99%

Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma

Agnelli¹,

Bicciato²,

Fabris³

et al. 2007

Haematologica

View full text Add to dashboard Cite

Background and Objectives The chromosome 13 deletion (Delta(13)) is one of the most frequent chromosomal alterations in multiple myeloma (MM). Delta(13) is associated with an unfavorable prognosis, although there is increasing agreement that its prognostic relevance must be related to the ploidy status and the presence of different chromosomal translocations. The aim of this study was to provide a comprehensive analysis of the transcriptional features of Delta(13) in MM.Design and Methods Highly purified plasma cells from 80 newly diagnosed MM patients were characterized by means of fluorescence in situ hybridization (FISH) and high-density oligonucleotide microarray for gene expression profiling and chromosomal alterations.Results We identified 67 differentially expressed genes in the patients with and without the chromosome 13 deletion, all of which were downregulated in the cases with Delta(13): 44 mapped along the whole chromosome 13, seven on chromosome 11 and three on chromosome 19. Functional analyses of the selected genes indicated their involvement in protein biosynthesis, ubiquitination and transcriptional regulation. An integrative genomic approach based on regional analyses of the gene expression data identified distinct chromosomal regions whose global expression modulation could differentiate Delta(13)-positive cases, in particular the upregulation of 1q21-1q42 and the downregulation of 19p and almost the entire chromosome 11. FISH analyses confirmed the close relationship between Delta(13)-positivity and the presence of extra copies of 1q21-1q42 (p=6x10(-4)) or the absence of chromosome 11 and 19 trisomy (p=5x10(-4)).Interpretation and Conclusions Our results indicate that distinct types of chromosomal aberrations are closely related to the transcriptional profiles of Delta(13)-positive cases, suggesting that the contribution of Delta(13) to the malignancy should be considered together with associated abnormalities

show abstract

Delineation of the minimal region of loss at 13q14 in multiple myeloma

Cited by 62 publications

References 32 publications

Secondary chromosomal abnormalities predict outcome in pediatric and adult high‐stage Burkitt lymphoma

Secondary chromosomal abnormalities predict outcome in pediatric and adult high‐stage Burkitt lymphoma

Role of miR-15/16 in CLL

Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma

Contact Info

Product

Resources

About