Deliberate Aspirin Intoxication

Madden, J. S.; Wilson, C. W. M.

doi:10.1136/bmj.1.5495.1090

Cited by 11 publications

(6 citation statements)

References 1 publication

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“…Across the included records, excessive use of NSAIDs amongst elite and non-elite athletes was described as a medical, such as to intoxicate) use of NSAIDs [5,8,11,12]. This inappropriate use of NSAIDs has increased in recent times, perhaps attributable to the self-care revolution [27], the increasing number and accessibility of medicines and the wide availability of online health information [13].…”

Section: Non-medical Use In Elite and Non-elite Athletesmentioning

confidence: 99%

“…NSAIDs are reported to be safe and effective if used within medical guidelines. However, inappropriate use has also been reported in the literature [4][5][6][7][8]. This can result in a broad spectrum of harms, including gastrotoxicity, hepatoxicity, nephrotoxicity, cardiotoxicity, overdose and even death [9,10], and increases the burden on healthcare systems.…”

Section: Introductionmentioning

confidence: 99%

“…Anecdotal reports, as well as several case reports and mini reviews, have highlighted the trend of extra-medical (using more than prescribed or recommended, for a medical reason) or non-medical (using for reasons other than medical, such as to intoxicate) use of NSAIDs [ 5 , 8 , 11 , 12 ]. This inappropriate use of NSAIDs has increased in recent times, perhaps attributable to the self-care revolution [ 27 ], the increasing number and accessibility of medicines and the wide availability of online health information [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

et al. 2021

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Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications worldwide and have analgesic, antipyretic and anti-inflammatory properties. Although NSAIDs are recognised as generally safe and effective, non-medical and extra-medical use of these products can occur. Unlike the use of illegal and many prescription drugs, which are subject to extensive research attention, inappropriate use of NSAIDs has been less well investigated. This scoping review collates and describes what is known regarding non-medical and extra-medical use of NSAIDs. In total, 72 studies were included in this scoping review. Three themes emerged from the review: (1) indicative profile of people who engage in non-medical or extra-medical use of NSAIDs; (2) antecedents for non-medical or extra-medical use; and (3) adverse health effects of non-medical and extra-medical use of NSAIDs. The review concluded that there is a need for enhanced patient education, including among sports people; pharmacovigilance in terms of clinician recognition of aberrance; and prescriber and pharmacist awareness of the potential for extra-medical and non-medical use and the related health harms.

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Section: Non-medical Use In Elite and Non-elite Athletesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

et al. 2021

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“…Authors Harvald, 1963Dawborn et al, 1966Gault and Rudwall, 1968Gseil et at, 1968Fellner and Tuttle, 1969Clarkson and Lawrence, 1970Koch et al, 1968 Country There have been isolated suggestions that aspirin may have mild sedative properties (Wolf«( al., 1941;Krumholz ei al., 1965), and a few cases of dependence have been recorded (Greer et al, 1965;Wilson and Madden, 1966;Savage, 1972). But these reports are extremely rare, and the mass of opinion is that aspirin has no psychoactivity (Eade and Lasagna 1967;Dinnerstein and Halme, 1970).…”

Section: Table 2 Physicians Comments On Psychiatric Disorder In Analmentioning

confidence: 98%

Dependence on Analgesics in Analgesic Nephropathy

Murray

1973

British Journal of Addiction to Alcohol & Other Drugs

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SnnmuiryFifty-one patients with analgesic nephropathy were studied over 3 years. Askit Powders and Codeine Co were the main preparations they had abused, and th: average amount they admitted was 6 daily fbr 20 years. The cause of analgesic nephropathy is dependence on analgesics, the characteristics of which include 1 A need to continue taking the analgesics. 2 A iendancy to slowly increase the dose, partly owing to tolerance and partly to treat symptoms the analgesic ingestion has caused. 3 A psychic dependence which results from appreaation of the psychotropic effects of the compound analgesics. 4 Severe withdrawal effects are rare. 5 The dependence causes a characteristic "sjmdrome of analgesic abuse."

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“…Aspirin misuse and dependence were first detailed in the Journal of the American Medical Association in 1940, 7 and have been described in several case reports/series since then. 8 , 9 In addition to continuous or episodic intake of aspirin without pharmacological purpose, cases describe deliberate salicylism (aspirin intoxication) to produce conditions of elation or inebriation. 10 Although salicylism received attention through the 1970s, the disorder has been poorly reported in the following decades.…”

mentioning

confidence: 99%

Aspirin misuse: a case report

et al. 2019

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Aspirin-use disorder is an underreported condition. Identification of the signs and symptoms of aspirin misuse are important in light of prevalent non-prescribed medicine/over-the-counter medication (NPM/OTC) misuse. We discuss here the case of a patient with a history of chronic aspirin misuse who presented to the emergency department with salicylate intoxication and described elation secondary to deliberate aspirin consumption. This case highlights the importance of screening for NPM/OTC medication misuse in at-risk populations.

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Deliberate Aspirin Intoxication

Cited by 11 publications

References 1 publication

A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Dependence on Analgesics in Analgesic Nephropathy

Aspirin misuse: a case report

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