Deletions in the Y-derived amelogenin gene fragment in the Indian population

Kashyap, Vivek; Sahoo, Sanghamitra; Sitalaximi, T.; Trivedi, R.

doi:10.1186/1471-2350-7-37

Cited by 58 publications

(41 citation statements)

References 18 publications

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“…None of the male sample presented reading error, as being homozygous (XX). Therefore, in this study, the "deleted-amelogenin males" or DAM issue did not occur, as reported by some authors [3,25]. Therefore, in all cases in which it was not possible to determine sex, it occurred due to the absence of the amplification of the gene, without the peak formation in the image.…”

Section: Discussionmentioning

confidence: 50%

Estudo estimativo do sexo em crânios oriundos da região metropolitana de Guarulhos utilizando Antropologia Física e DNA

Carvalho

Brito

Paiva

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIvE: This study aimed to determine the sex in human craniums using methodologies of Physical Anthropology, quantitative (Forensic Data Anthropology Bank, FDB, 1986) and one qualitative (Walker, 2008) and genetic analysis by amelogenin. METhODS: The sample was composed of 66 skulls (34 males and 32 females) from the Center for Study and Research in Forensic Science, Guarulhos, SP. The methodologies were applied by two researchers who were unaware of the cranium's sexes. For the statistical analysis, there were performed descriptive analysis, average, standard deviation, linear discriminant analysis and logistic regression. RESUlTS: The qualitative methodology presented an accuracy of 89.52%. For the DNA, it was possible to determine the sex in 86.15% of the sample. Analyzing the results for each skull in three different methodologies, we reached 100% correct. CONClUSION: As a result of this study, it is recommended that physical anthropology be the chosen method if it presents good accuracy when applied to different populations or if it is validated for the analyzed population. Otherwise, genetic analysis should be used for the determination of the sex.Key words: Physical Anthropology; DNA; Molecular Biology; Sex characteristics; Sex differentiation Estudo estimativo do sexo em crânios oriundos da região metropolitana de Guarulhos utilizando Antropologia Física e DNA RESumo OBJETIvO: O presente estudo propõe determinar o sexo de crânios humanos, a partir de metodologias quantitativa (Forensic Data Anthropology Bank, FDB, 1986) e qualitativa (Walker, 2008) da antropologia física além de análise genética da amelogenina. MéTODOS: A amostra foi composta de 66 esqueletos (34 masculinos e 32 femininos) do Centro de Estudos e Pesquisa Forense de Guarulhos, SP. As metodologias de avaliação foram aplicadas por dois pesquisadores que desconheciam o sexo dos crânios. Para análise estatísitica, foi realizada análise descritiva (média e desvio-padrão). RESUlTADOS: A análise qualitativa alcançou uma acurácia de 89.52%. A partir da análise do DNA, foi possível determinar o sexo em 86.15% das amostras. Ao avaliar, cada crânio, seguindo as 3 metodologias, foi possível alcançar 100% de acurácia. CONClUSãO: A partir dos resultados do presente estudo, fica recomendado o uso da antropologia física para a determinaçnao do sexo, desde que esteja validada para a população em análise. Além disso, a análise genética deve ser utilizada para a determinação do sexo de crânios humanos.

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Section: Discussionmentioning

confidence: 50%

Estudo estimativo do sexo em crânios oriundos da região metropolitana de Guarulhos utilizando Antropologia Física e DNA

Carvalho

Brito

Paiva

et al. 2017

Rev. Odonto Ciênc. (Online)

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“…The relatively high frequency of R2a-M124 in the Lingayat (15.84%) and Vokkaliga (13.73%) populations, combined with their high microsatellite variance ( Figure 5 and Table 4) and deep coalescence times (24.64 kya and 11.91 kya, respectively) support the indigenous origin of this haplogroups in India (Kivisild et al, 2003;Sahoo et al, 2006;Sengupta et al, 2006). However, the age for R2a-M124 in Lingayat (24.64 kya) should be interpreted with caution given the history of the population.…”

Section: Haplogroups R1a1a-m198 and R2a-m124 Are Pan-indian Markersmentioning

confidence: 99%

“…Besides its widespread distributions in South Asian populations, including India, Pakistan, Sri Lanka and Nepal (Wells et al, 2001;Kivisild et al, 2003;Sahoo et al, 2006;Sengupta et al, 2006;Thanseem et al, 2006;Gayden et al, 2007), haplogroup H-M69 is also present at high frequency among Romani groups residing in Europe (Gresham et al, 2001;Pericic et al, 2005;Gusmao et al, 2008;Klaric et al, 2009;Regueiro et al, 2011). Therefore, it is not surprising that the Kosovo Roma from Serbia maps with Indian populations in the CA plot ( Figure 2) and ML (Figure 3) phylogeny.…”

Section: Ancient South Asian Lineagesmentioning

confidence: 99%

“…The IndoEuropean speakers are the largest speaking group followed by Dravidians, Austro-Asiatic and Tibeto-Burman language families (Basu et al, 2003;Sahoo et al, 2006). With the exception of the Austro-Asiatic speakers, who are exclusively tribal, the other three language families are spoken by members of both caste and tribal groups (Sahoo et al, 2006;Majumder, 2008).…”

mentioning

confidence: 99%

“…The people of contemporary India represent a mosaic of ethnic, linguistic, cultural and genetic diversity (Basu et al, 2003;Sahoo et al, 2006;Terreros et al, 2007). The vast majority of the Indian populations (80.5%) (Census of India, 2001) belong to the Hindu religion, the members of which are socially stratified into castes on the basis of their occupation.…”

mentioning

confidence: 99%

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Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India

Chennakrishnaiah¹

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Signatures of high altitude adaptation in Tibeto‐Burman tribes of the Darjeeling Hill Region

Rai

Tamang

et al. 2023

American J Hum Biol

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Objectives: The long-term isolation, endogamy practices, and environmental adaptations have shaped the enormous human diversity in India. The genetic and morphological variations in mainland Indians are well studied. However, the data on the Indian Himalayan populations are scattered. Thus, the present study attempts to understand variations in the selected parameter among four Tibeto-Burman speaking ethnic tribal populations from the Darjeeling Hill Region (DHR) in the Eastern Himalaya Biodiversity Hotspot region of India.Methods: A total of 178 healthy male individuals (Lepcha 98, Sherpa 31, Bhutia 27, and Tibetans 22) living at an altitudinal range of 1467-2258 m above the sea level were studied for the 10 parameters namely, weight (kg), height (cm), body mass index (BMI) (kg/m 2 ) systolic and diastolic pressure (mm of Hg), pulse rate (per minute), saturation of peripheral oxygen (SPO 2 ) (%), hemoglobin (g/dl), hematocrit (HCT) (%), and blood glucose (mg/dl). The data was statistically analyzed using analysis of variance and multiple linear regression methods. Results: Our analysis revealed comparatively lower hemoglobin and HCT levels, and higher systolic and diastolic blood pressure in the Sherpas followed by the Tibetans. This may be reflecting the persistence of high-altitude adaptation signatures even in lowlands. Interestingly, the Tibetans differed significantly from other populations in terms of their higher body weight, height, and BMI. Conclusion: Thus, our study showed the persistence of high altitude signatures in Tibetans and Sherpa inhabited the DHR. Additionally, we also observed significant differences in the anthropometric and physiological parameters among the Tibeto-Burman populations of the DHR.

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Deletions in the Y-derived amelogenin gene fragment in the Indian population

Abstract: Background: Rare failures in amelogenin-based gender typing of individuals have been observed globally. In this study, we report the deletion of a large fragment of the amelogenin gene in 10 individuals out of 4,257 male samples analyzed from 104 different endogamous populations of India.

Cited by 58 publications

References 18 publications

Estudo estimativo do sexo em crânios oriundos da região metropolitana de Guarulhos utilizando Antropologia Física e DNA

Estudo estimativo do sexo em crânios oriundos da região metropolitana de Guarulhos utilizando Antropologia Física e DNA

Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India

Signatures of high altitude adaptation in Tibeto‐Burman tribes of the Darjeeling Hill Region

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