Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.

Nakai, Kenta; Itoh, Chuichi; Miura, Yoshinori; Hotta, Kenji; Musha, Takehiko; Itoh, Tomonori; Miyakawa, Tomohisa; Iwasaki, Ryu; Hiramori, Katsuhiko

doi:10.1161/01.cir.90.5.2199

Cited by 238 publications

(122 citation statements)

References 21 publications

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“…12 Since that time a lot of studies were performed in which ACE genotype was used as a tool, through association studies, to investigate the role of tissue ACE in human disease pathogenesis. [13][14][15][16][17] Taken together, the available evidence supports the notion that the DD ACE genotype adversely influences specific cardiovascular diseases but appears to do so in specific geographical areas and in particular patient subgroups. 18 This can be a possible explanation of the inconsistency of association between ACE genotype and ED.…”

Section: Introductionsupporting

confidence: 62%

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

et al. 2007

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This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group (Po0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes (Po0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age (Po0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro-and macrovascular diseases.

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Section: Introductionsupporting

confidence: 62%

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

et al. 2007

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“…Therefore, control genotyping assays are mandatory in presumed DD carriers (Lin et al 2001). Mechanistically, the D allele is associated with increased levels (approximately twofold in homozygous carriers) of ACE in Caucasian and Asian but not in African populations (Rigat et al 1990;Nakai et al 1994;Bloem et al 1996). Other groups have confirmed that this polymorphism accounts for half of the observed variance in ACE plasma levels.…”

Section: Polymorphisms In the Angiotensin Converting Enzymementioning

confidence: 99%

Genetics of arterial hypertension and hypotension

Rosskopf

Schürks

Rimmbach

et al. 2007

Naunyn-Schmied Arch Pharmacol

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Human hypertension affects affects more than 20% of the adult population in industrialized countries, and it is implicated in millions of deaths worldwide each year from stroke, heart failure and ischemic heart disease. Available evidence suggests a major genetic impact on blood pressure regulation. Studies in monogenic hypertension revealed that renal salt and volume regulation systems are predominantly involved in the genesis of these disorders. Mutations here affect the synthesis of mineralocorticoids, the function of the mineralocorticoid receptor, epithelial sodium channels and their regulation by a new class of kinases, termed WNK kinases. It has been learned from monogenic hypotension that almost all ion transporters involved in the renal uptake of Na + have a major impact on blood pressure regulation. For essential hypertension as a complex disease, many candidate genes have been analysed. These include components of the reninangiotensin-aldosterone system, adducin, β-adrenoceptors, G protein subunits, regulators of G protein signalling (RGS) proteins, Rho kinases and G protein receptor kinases. At present, the individual impact of common polymorphisms in these genes on the observed blood pressure variation, on risk for stroke and as predictors of antihypertensive responses remains small and clinically irrelevant. Nevertheless, these studies have greatly augmented our knowledge on the regulation of renal functions, cellular signal transduction and the integration of both. Together, this provides the basis for the identification of novel drug targets and, hopefully, innovative antihypertensive drugs.

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“…These findings have also been shown in other populations, even in prospective studies. 10,11 However, not all studies have demonstrated this association. 12,13 There are few studies that have investigated the association between BMI, ACE gene I/D polymorphism and CHD.…”

Section: Introductionmentioning

confidence: 99%

The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease

Riera-Fortuny

Real

Chaves³

et al. 2004

Int J Obes

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OBJECTIVE:To analyse the relation between overweight, obesity and fat distribution with I/D polymorphism of the angiotensinconverting enzyme (ACE) gene and its association with coronary heart disease (CHD). DESIGN: Cross-sectional, case-control study. SUBJECTS: A total of 185 cases (141 males) who had suffered at least one episode of CHD and 182 controls (127 males). MEASUREMENTS: Body mass index, waist circumference, blood pressure, plasma total cholesterol, triglycerides, HDL cholestrol and fasting glucose were measured with standard methods, genotyping the I/D polymorphism of ACE gene. RESULTS: Obesity and abdominal fat deposit are associated with CHD in women, but not independently. We have found an association between obesity and abdominal fat deposit with the ACE gene I/D polymorphism in subjects with CHD. Subjects with CHD and DD or ID genotypes have significantly higher prevalence of obesity and abdominal fat deposit and higher values of weight and waist circumference. In addition, the DD and ID genotypes increased crude OR of obesity. The DD and ID genotypes of the ACE gene I/D polymorphism and BMI are independently associated with CHD. CONCLUSION: There is a relation between the type and grade of obesity with the genotypes of the ACE gene I/D polymorphism in subjects with CHD.

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Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.

Abstract: A deletion polymorphism of the ACE gene is associated with serum ACE activity and increased risk for CAD in the Japanese.

Cited by 238 publications

References 21 publications

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Genetics of arterial hypertension and hypotension

The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease

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