Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Мазо, Е Б; Гамидов, С. И.; Мамедов, М. Н.; Iremashvili, Viacheslav

doi:10.1038/sj.ijir.3901598

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…14,34 Park et al 35 re por ted that the DD ge noty pe might be se en mo re fre qu ently in men with a di ag no sis of vas cu lo ge nic erec ti le dysfunc ti on in a Ko re an po pu la ti on. In anot her study, Ma zo et al 36 fo und that, the pre va len ce of DD genoty pe in the ED gro up was sig ni fi cantly hig her than the non-ED gro up (p< 0.001). Anot her study in ves ti ga ting the sa me ge ne poly morp hism and ED was published by Ei sen hardt et al 9 This study enrol led 113 pa ti ents with ED and 108 con trols.…”

Section: Discussionmentioning

confidence: 91%

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Cam¹,

Gümüş²,

Var³

et al. 2011

Turkiye Klinikleri J Med Sci

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432rectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse, 1 and is a frequent chronic disorder increasing with age. In a community-based random sample observational study, 2 the total prevalen- Association of Angiotensin-ConvertingEnzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re cent stu di es sug gest that an gi o ten sin II and nit ric oxi de (NO) may mo du la te pe ni le smo oth musc le to ne and con trac ti lity. Be ca u se ge noty pes of the an gi o ten sin con ver ting enz yme (ACE) and en dot he li al nit ric oxi de syntha se (eNOS) poly morp hisms ha ve be en as so ci a ted with di sor ders in the vas cu lar system, in this study, we in ves ti ga ted an as so ci a ti on bet we en the ACE I/D and eNOS G894T ge ne poly morp hisms and erec ti le dysfunc ti on (ED). M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : A to tal of 44 pa ti ents and 45 con trol sub jects we re inc lu ded in the study. Di ag no sis of erec tile dysfunc ti on (< 26) was pro vi ded by In ter na ti o nal In dex of Erec ti le Func ti on (II EF). The ACE I/D ve eNOS G894T ge ne poly morp hisms we re ge noty ped using PCR and RFLP. R Re e s su ul lt ts s: : No sig ni fi cant ca se-con trol dif fe ren ce was ob ser ved for the ACE I/D and eNOS G894T ge ne poly morp hisms either by ge noty pe or al le le fre qu en ci es [(ACE I/D-X 2 = 0.930 p= 0.628) and eNOS 894 G/T-X 2 = 2.114 p = 0.348)]. In addition, the re was no sig ni fi cant dif fe ren ce bet we en ACE I/D (X 2 = 3.174 p= 0.787) and eNOS G894T (X 2 = 4.320 p= 0.633) and II EF sco res among the pa ti ent gro up. C Co on nc c l lu u s si i o on n: : In this study, no as so ci a ti on was fo und bet we en ACE I/D and eNOS G894T ge ne poly morp hisms and erecti le dysfunc ti on in the Tur kish po pu la ti on stu di ed.K Ke ey y W Wo or rd ds s: : Erec ti le dysfunc ti on; poly morp hism, angiotensin-converting enzyme Ö ÖZ ZE ET T A Am ma aç ç: : Ya pı lan ça lış ma lar da nit rik ok sit (NO) ve an ji yo ten sin II'nin pe nil düz kas la rın to nüs ve kon trak ti li te si ni et ki le ye bil di ği ile ri sü rül mek te dir. An ji yo ten sin dö nüş tü rü cü en zim (ACE-ADE) ve en do te li yal nit rik ok sit sen taz (eNOS) gen po li mor fizm le ri da mar has ta lık la rı ile iliş ki li ol duk ların dan, bu ça lış ma da, erek til dis fonk si yon ile eNOS 894 G/T (Glu298Asp) ve ACE I/D gen po li morfizm le ri ara sın da ki iliş ki nin in ce le me si amaç lan mış tır. G Ge er re eç ç v ve e Y Yö ön n t te em ml le er r: : Ça lış ma ya erek til dis fonk si yo nu (ED) olan 44 has ta ile 45 sağ lık lı kon trol gru bu alın dı. ED ta nı sı (< 26), Ulus la ra ra sı Erek til Fonk si yon İndek si ne (II EF) gö re de ğer len di ril di. Has ta ve kon trol gru bun da ACE I/D ve eNOS 894 G/T gen po li mor fizm le ri, po li me raz zin cir re ak si yo nu ve kı sıt la yı cı en zim ke si mi yön tem le ri ile sap tan dı. B ...

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Section: Discussionmentioning

confidence: 91%

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Cam¹,

Gümüş²,

Var³

et al. 2011

Turkiye Klinikleri J Med Sci

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“…Rosas-Vargas et al (2004) 22 (42) 26 (49) 5 (9) 18 (29) 31 (50) 13 (21) 70 (66) 36 (34) 67 (54) 57 (46) 0.002 0.958 Mazo et al (2008) 10 (6) 48 (26) 124 (68) 15 (10) 78 (52) 56 (38) 68 (19) 296 (81) 108 (36) 190 (64) 2.626 0.105 Andersen et al (2010) 11 (16) 33 (46) 27 (38) 50 (15) 159 (48) 125 (37) 55 (39) 87 (61) 259 (39) 409 (61) 0.002 0.961 Eisenhardt et al (2010) 86 (19) 238 (52) 131 (29) 17 (16) 62 (57) 29 (27) 410 (45) 500 (55) 96 (44) 120 (56) 2.852 0.091 Latino and European. Thus, the polymorphism may not increase ED risk in different population.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…Of these, one article Eisenhardt & Siffert, 2003) was excluded because it contained overlapping data from the same investigators. Thus, a total of six case-control studies were finally included in our meta-analysis (Park et al, 1999;Kim et al, 2001;Rosas-Vargas et al, 2004;Mazo et al, 2008;Andersen et al, 2010;Eisenhardt et al, 2010). Characteristics of the six case-control studies included are summarized in Table 1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Studies were carried out in various ethnicities: two involved Asian (Park et al, 1999;Kim et al, 2001), two involved Latino (Rosas-Vargas et al, 2004;Andersen et al, 2010) and two involved European (Mazo et al, 2008;Eisenhardt et al, 2010). Assessment of ED was from a variety of sources, including colour doppler ultrasonography (Park et al, 1999;Kim et al, 2001;Eisenhardt et al, 2010), vasoactive drug-induced erection test (Rosas-Vargas et al, 2004), International index of Erectile Function-5 (IIEF-5) (Mazo et al, 2008) and an eight-item questionnaire (Andersen et al, 2010). The determination of the genetic polymorphisms used in all the studies are polymerase chain reaction (PCR).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Sayed-Tabatabaei et al, 2006), and, although a significant association between the DD genotype of the ACE gene polymorphism and ED in a sample of Koreans was observed (Park et al, 1999), results of association studies regarding the relationship between ACE I/D polymorphism and ED risk have remained inconsistent. More specifically, Mazo et al reported that in patients with metabolic syndrome, the prevalence of the DD genotype was found to be significantly higher compared with the non-ED group, reinforcing the idea that the I/D polymorphism may indeed play an important role in the development of ED (Mazo et al, 2008). More recently, However, Andersen and colleagues did not detect a significant association between the ACE gene polymorphism and ED risk in Brazilian population (Andersen et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

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The insertion/deletion (I/D) polymorphism in the angiotensin‐converting enzyme gene and erectile dysfunction risk: a meta‐analysis

Zhang

et al. 2012

Andrology

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SUMMARYErectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of the relationship, a meta-analysis was conducted using data published previously by other groups. A total of six case-control studies, including 1039 cases and 927 controls, were selected. The pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) were calculated by comparing the carriers of D-allele with the wild homozygotes (ID + DD vs. II). Comparisons of other genetic models were also performed (ID + II vs. DD, DD vs. II, DI vs. II and D vs. I). In the overall analysis, no significant association between the polymorphism and ED risk was observed (OR=1.07, 95% CI = 0.84 À 1.37, p = 0.575 for ID + DD vs. II). In the subgroup analysis by ethnic, no significant association was detected among Asian, Latino and European for the comparison of ID + DD vs. II (Asian: OR=1.27, 95% CI = 0.89 À 1.81; Latino: OR=0.76, 95% CI = 0.46 À 1.27; European: OR=1.06, 95% CI = 0.67 À 1.66). Results from other comparative genetic models also indicated the lack of associations between this polymorphism and ED risk. In conclusion, this meta-analysis indicates that the ACE I/D polymorphism might not contribute to the risk of ED.

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Einzelbasenpaarpolymorphismen und erektile Dysfunktion

Eisenhardt

Rübben²,

Sperling

2008

Urologe

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The risk for erectile dysfunction is closely linked to cardiovascular morbidities such as coronary heart disease, arterial hypertension, hypercholesterolemia, and diabetes. Molecular analysis revealed an association between the genotypes in single base polymorphisms and the risk for these cardiovascular morbidities. In this review the current knowledge of association studies of single nucleotide polymorphisms and erectile dysfunction and the response to the PDE-5 inhibitor sildenafil is described.

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Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Cited by 14 publications

References 26 publications

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

The insertion/deletion (I/D) polymorphism in the angiotensin‐converting enzyme gene and erectile dysfunction risk: a meta‐analysis

Einzelbasenpaarpolymorphismen und erektile Dysfunktion

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