Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Abstract

432rectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse, 1 and is a frequent chronic disorder increasing with age. In a community-based random sample observational study, 2 the total prevalen- Association of Angiotensin-ConvertingEnzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re cent stu di es sug gest that an gi o ten sin II and nit ric oxi de (NO) may mo du la te pe ni le smo oth musc le to ne and con trac ti lity. Be ca u se ge noty pes of the an gi o ten sin con ver ting enz yme (ACE) and en dot he li al nit ric oxi de syntha se (eNOS) poly morp hisms ha ve be en as so ci a ted with di sor ders in the vas cu lar system, in this study, we in ves ti ga ted an as so ci a ti on bet we en the ACE I/D and eNOS G894T ge ne poly morp hisms and erec ti le dysfunc ti on (ED). M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : A to tal of 44 pa ti ents and 45 con trol sub jects we re inc lu ded in the study. Di ag no sis of erec tile dysfunc ti on (< 26) was pro vi ded by In ter na ti o nal In dex of Erec ti le Func ti on (II EF). The ACE I/D ve eNOS G894T ge ne poly morp hisms we re ge noty ped using PCR and RFLP. R Re e s su ul lt ts s: : No sig ni fi cant ca se-con trol dif fe ren ce was ob ser ved for the ACE I/D and eNOS G894T ge ne poly morp hisms either by ge noty pe or al le le fre qu en ci es [(ACE I/D-X 2 = 0.930 p= 0.628) and eNOS 894 G/T-X 2 = 2.114 p = 0.348)]. In addition, the re was no sig ni fi cant dif fe ren ce bet we en ACE I/D (X 2 = 3.174 p= 0.787) and eNOS G894T (X 2 = 4.320 p= 0.633) and II EF sco res among the pa ti ent gro up. C Co on nc c l lu u s si i o on n: : In this study, no as so ci a ti on was fo und bet we en ACE I/D and eNOS G894T ge ne poly morp hisms and erecti le dysfunc ti on in the Tur kish po pu la ti on stu di ed.K Ke ey y W Wo or rd ds s: : Erec ti le dysfunc ti on; poly morp hism, angiotensin-converting enzyme Ö ÖZ ZE ET T A Am ma aç ç: : Ya pı lan ça lış ma lar da nit rik ok sit (NO) ve an ji yo ten sin II'nin pe nil düz kas la rın to nüs ve kon trak ti li te si ni et ki le ye bil di ği ile ri sü rül mek te dir. An ji yo ten sin dö nüş tü rü cü en zim (ACE-ADE) ve en do te li yal nit rik ok sit sen taz (eNOS) gen po li mor fizm le ri da mar has ta lık la rı ile iliş ki li ol duk ların dan, bu ça lış ma da, erek til dis fonk si yon ile eNOS 894 G/T (Glu298Asp) ve ACE I/D gen po li morfizm le ri ara sın da ki iliş ki nin in ce le me si amaç lan mış tır. G Ge er re eç ç v ve e Y Yö ön n t te em ml le er r: : Ça lış ma ya erek til dis fonk si yo nu (ED) olan 44 has ta ile 45 sağ lık lı kon trol gru bu alın dı. ED ta nı sı (< 26), Ulus la ra ra sı Erek til Fonk si yon İndek si ne (II EF) gö re de ğer len di ril di. Has ta ve kon trol gru bun da ACE I/D ve eNOS 894 G/T gen po li mor fizm le ri, po li me raz zin cir re ak si yo nu ve kı sıt la yı cı en zim ke si mi yön tem le ri ile sap tan dı. B ...

The insertion/deletion (I/D) polymorphism in the angiotensin‐converting enzyme gene and erectile dysfunction risk: a meta‐analysis

“…Further screening of these articles, three of them were excluded for being not relevant to ED risk with ACE gene polymorphism and two articles (Ç am et al, 2011;Gamidov et al, 2011) were not included for the language are neither English nor Chinese. Thus, seven articles relevant to ACE I/D polymorphism and ED risk for more detailed evaluation.…”